Interleukin 10-induced thrombocytopenia in normal healthy adult volunteers: evidence for decreased platelet production

Recombinant human interleukin 10 (rhuIL-10) inhibits the production of proinflammatory cytokines and has shown promise in the treatment of inflammatory bowel disease. Clinical trials have been accompanied by a reversible decline in platelet counts. We conducted a randomized, double-blinded, placebo-...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	British journal of haematology 2000-10, Vol.111 (1), p.104-111
Hauptverfasser:	SOSMAN, Jeffrey A, VERMA, Amit, BRUNO, Edward, GUSTIN, David, VIANA, Marlos, HOFFMAN, Ronald, MOSS, Steven, SOROKIN, Patricia, BLEND, Michael, BRADLOW, Basil, CHACHLANI, Nasir, CUTLER, David, SABO, Ronald, NELSON, Mary
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Blood Platelets - drug effects Cell Count Double-Blind Method Drug toxicity and drugs side effects treatment Female Hematology Hemoglobins - analysis Humans Interleukin-10 - pharmacology Male Medical sciences Megakaryocytes - pathology Pharmacology. Drug treatments Platelet Count Recombinant Proteins - pharmacology Spleen - physiopathology Statistics, Nonparametric Thrombocytopenia - blood Thrombocytopenia - immunology Toxicity: blood
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!