Inhibition of P-glycoprotein by orange juice components, polymethoxyflavones in adriamycin-resistant human myelogenous leukemia (K562/ADM) cells

We investigated the effects of the ethyl acetate extract of grapefruit juice (GFJ), that of orange juice (OJ) and their components on the uptake of [ 3H]vincristine into adriamycin-resistant human myelogenous leukemia cells. Its uptake was increased by the extracts of GFJ and OJ up to 7- and 3-fold,...

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Veröffentlicht in:	Cancer letters 2000-11, Vol.160 (1), p.21-28
Hauptverfasser:	Ikegawa, Tomomi, Ushigome, Fumihiko, Koyabu, Noriko, Morimoto, Satoshi, Shoyama, Yukihiro, Naito, Mikihiko, Tsuruo, Takashi, Ohtani, Hisakazu, Sawada, Yasufumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates Antineoplastic agents ATP Binding Cassette Transporter, Subfamily B - antagonists & inhibitors ATP Binding Cassette Transporter, Subfamily B - metabolism Beverages Biological and medical sciences Blotting, Western Cancer chemotherapy Chemotherapy Citrus - chemistry Cyclosporine - pharmacology Dose-Response Relationship, Drug Doxorubicin - pharmacology Drug Resistance, Multiple Drug Resistance, Neoplasm Flavones Flavonoids - pharmacology Furocoumarins - chemistry Furocoumarins - pharmacology Grapefruit juice Humans K562 Cells - drug effects K562 Cells - metabolism Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology Medical sciences Methoxyflavone Multidrug resistance Orange juice Pharmacology. Drug treatments Plant Extracts - chemistry Plant Extracts - pharmacology Tritium Verapamil - pharmacology Vincristine Vincristine - pharmacokinetics
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