NF-kappaB and AP-1 are responsible for inducibility of the IL-6 promoter by ionizing radiation in HeLa cells

To investigate the mechanisms leading to initiation by ionizing radiation of IL-6 transcription in HeLa cells. HeLa cells were irradiated with X-rays at a dose rate of approximately 1 Gy/min or treated with TPA (100 ng/ml). Transient transfection analysis with truncated IL-6 promoter CAT constructs...

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Veröffentlicht in:	International journal of radiation biology 2000-11, Vol.76 (11), p.1443-1453
Hauptverfasser:	Beetz, A, Peter, R U, Oppel, T, Kaffenberger, W, Rupec, R A, Meyer, M, van Beuningen, D, Kind, P, Messer, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites - genetics Chloramphenicol O-Acetyltransferase - genetics DNA Primers - genetics Enhancer Elements, Genetic - radiation effects HeLa Cells Humans Interleukin-6 - genetics NF-kappa B - metabolism Promoter Regions, Genetic - radiation effects Radiation Tolerance - genetics Space life sciences Transcription Factor AP-1 - metabolism Transcriptional Activation - radiation effects Transfection
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