Identification of Connective Tissue Growth Factor as a Target of WT1 Transcriptional Regulation

The Wilms tumor suppressor WT1 has transcription-activating and -suppressing capabilities. WT1-responsive promoters have been described; however, in large part, it remains unclear which potential downstream genes are physiologically relevant and mediate the function of WT1 in tumorigenesis and devel...

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Veröffentlicht in:	The Journal of biological chemistry 2000-12, Vol.275 (49), p.38139-38150
Hauptverfasser:	Stanhope-Baker, Patricia, Williams, Bryan R.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Neoplasm Base Sequence Connective Tissue Growth Factor DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene Expression Regulation, Neoplastic Genes, Reporter Genes, Wilms Tumor Growth Substances - genetics Humans Immediate-Early Proteins - genetics Intercellular Signaling Peptides and Proteins Kidney Neoplasms Kinetics Mitogens - genetics Molecular Sequence Data Neoplasm Proteins - genetics Promoter Regions, Genetic Recombinant Proteins - metabolism Reverse Transcriptase Polymerase Chain Reaction Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic Transfection Tumor Cells, Cultured Wilms Tumor WT1 protein WT1 Proteins Zinc Fingers
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