Parvovirus Infection of Keratinocytes as a Cause of Canine Erythema Multiforme
Erythema multiforme major was diagnosed in a dog with necrotizing parvoviral enteritis. Skin lesions consisted of ulceration of the footpads, pressure points, mouth, and vaginal mucosa; vesicles in the oral cavity; and erythematous patches on the abdomen and perivulvar skin. Microscopic examination...
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| Veröffentlicht in: | Veterinary pathology 2000-11, Vol.37 (6), p.647-649 |
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| container_title | Veterinary pathology |
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| creator | Favrot, C. Olivry, T. Dunston, S. M. Degorce-Rubiales, F. Guy, J. S. |
| description | Erythema multiforme major was diagnosed in a dog with necrotizing parvoviral enteritis. Skin lesions consisted of ulceration of the footpads, pressure points, mouth, and vaginal mucosa; vesicles in the oral cavity; and erythematous patches on the abdomen and perivulvar skin. Microscopic examination of mucosal and haired skin specimens revealed lymphocyte-associated keratinocyte apoptosis at various levels of the epidermis. Basophilic cytoplasmic inclusions were seen in basal and suprabasal keratinocytes. Immunohistochemical staining, performed with canine parvovirus-2-specific monoclonal antibodies, confirmed the parvovirus nature of the inclusions in the nucleus and cytoplasm of oral and skin epithelial cells. This is the first case of canine erythema multiforme reported to be caused by a viral infection of keratinocytes. This case study indicates that the search for epitheliotropic viruses should be attempted in cases of erythema multiforme in which a drug cause cannot be identified. |
| doi_str_mv | 10.1354/vp.37-6-647 |
| format | Article |
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This is the first case of canine erythema multiforme reported to be caused by a viral infection of keratinocytes. 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M.</creatorcontrib><creatorcontrib>Degorce-Rubiales, F.</creatorcontrib><creatorcontrib>Guy, J. S.</creatorcontrib><title>Parvovirus Infection of Keratinocytes as a Cause of Canine Erythema Multiforme</title><title>Veterinary pathology</title><addtitle>Vet Pathol</addtitle><description>Erythema multiforme major was diagnosed in a dog with necrotizing parvoviral enteritis. Skin lesions consisted of ulceration of the footpads, pressure points, mouth, and vaginal mucosa; vesicles in the oral cavity; and erythematous patches on the abdomen and perivulvar skin. Microscopic examination of mucosal and haired skin specimens revealed lymphocyte-associated keratinocyte apoptosis at various levels of the epidermis. Basophilic cytoplasmic inclusions were seen in basal and suprabasal keratinocytes. Immunohistochemical staining, performed with canine parvovirus-2-specific monoclonal antibodies, confirmed the parvovirus nature of the inclusions in the nucleus and cytoplasm of oral and skin epithelial cells. This is the first case of canine erythema multiforme reported to be caused by a viral infection of keratinocytes. This case study indicates that the search for epitheliotropic viruses should be attempted in cases of erythema multiforme in which a drug cause cannot be identified.</description><subject>Animals</subject><subject>Antibodies, Monoclonal</subject><subject>Antibodies, Viral - analysis</subject><subject>Dog Diseases - etiology</subject><subject>Dog Diseases - virology</subject><subject>Dogs</subject><subject>Erythema Multiforme - etiology</subject><subject>Erythema Multiforme - veterinary</subject><subject>Erythema Multiforme - virology</subject><subject>Female</subject><subject>Foot</subject><subject>Foot Ulcer - veterinary</subject><subject>Foot Ulcer - virology</subject><subject>Immunoenzyme Techniques - veterinary</subject><subject>Keratinocytes - virology</subject><subject>Necrosis</subject><subject>Parvoviridae Infections - pathology</subject><subject>Parvoviridae Infections - veterinary</subject><subject>Parvovirus, Canine - isolation & purification</subject><subject>Skin - pathology</subject><issn>0300-9858</issn><issn>1544-2217</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkE1Lw0AQQBdRbK2evEtOIkjqfic5SqharB8HPS-T7a6mJNm4mwT6701pwYswMId5PJiH0CXBc8IEvxvaOUtiGUueHKEpEZzHlJLkGE0xwzjOUpFO0FkIG4wpzdLkFE0IIVhkgk_R6zv4wQ2l70O0bKzRXemayNno2XjoysbpbWdCBONEOfTB7G45NGVjooXfdt-mhuilr7rSOl-bc3RioQrm4rBn6PNh8ZE_xau3x2V-v4o1p6SLM0GBaAmcp1RIzKSQusByrZlNNBSGcks4L8AwKi0vMOYE0ywBzsRaWglshq733ta7n96ETtVl0KaqoDGuDyqhnJEsTUfwdg9q70LwxqrWlzX4rSJY7fKpoVUsUVKN-Ub66qDti9qs_9hDrxG42QMBvozauN4345v_un4BGKx3dg</recordid><startdate>20001101</startdate><enddate>20001101</enddate><creator>Favrot, C.</creator><creator>Olivry, T.</creator><creator>Dunston, S. 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S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-952a1c6a44825603656cb06dc3f7cabe24f144bae326f4b00410297a435d6f6a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Antibodies, Monoclonal</topic><topic>Antibodies, Viral - analysis</topic><topic>Dog Diseases - etiology</topic><topic>Dog Diseases - virology</topic><topic>Dogs</topic><topic>Erythema Multiforme - etiology</topic><topic>Erythema Multiforme - veterinary</topic><topic>Erythema Multiforme - virology</topic><topic>Female</topic><topic>Foot</topic><topic>Foot Ulcer - veterinary</topic><topic>Foot Ulcer - virology</topic><topic>Immunoenzyme Techniques - veterinary</topic><topic>Keratinocytes - virology</topic><topic>Necrosis</topic><topic>Parvoviridae Infections - pathology</topic><topic>Parvoviridae Infections - veterinary</topic><topic>Parvovirus, Canine - isolation & purification</topic><topic>Skin - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Favrot, C.</creatorcontrib><creatorcontrib>Olivry, T.</creatorcontrib><creatorcontrib>Dunston, S. M.</creatorcontrib><creatorcontrib>Degorce-Rubiales, F.</creatorcontrib><creatorcontrib>Guy, J. S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Favrot, C.</au><au>Olivry, T.</au><au>Dunston, S. M.</au><au>Degorce-Rubiales, F.</au><au>Guy, J. S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Parvovirus Infection of Keratinocytes as a Cause of Canine Erythema Multiforme</atitle><jtitle>Veterinary pathology</jtitle><addtitle>Vet Pathol</addtitle><date>2000-11-01</date><risdate>2000</risdate><volume>37</volume><issue>6</issue><spage>647</spage><epage>649</epage><pages>647-649</pages><issn>0300-9858</issn><eissn>1544-2217</eissn><abstract>Erythema multiforme major was diagnosed in a dog with necrotizing parvoviral enteritis. Skin lesions consisted of ulceration of the footpads, pressure points, mouth, and vaginal mucosa; vesicles in the oral cavity; and erythematous patches on the abdomen and perivulvar skin. Microscopic examination of mucosal and haired skin specimens revealed lymphocyte-associated keratinocyte apoptosis at various levels of the epidermis. Basophilic cytoplasmic inclusions were seen in basal and suprabasal keratinocytes. Immunohistochemical staining, performed with canine parvovirus-2-specific monoclonal antibodies, confirmed the parvovirus nature of the inclusions in the nucleus and cytoplasm of oral and skin epithelial cells. This is the first case of canine erythema multiforme reported to be caused by a viral infection of keratinocytes. This case study indicates that the search for epitheliotropic viruses should be attempted in cases of erythema multiforme in which a drug cause cannot be identified.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>11105954</pmid><doi>10.1354/vp.37-6-647</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antibodies, Monoclonal Antibodies, Viral - analysis Dog Diseases - etiology Dog Diseases - virology Dogs Erythema Multiforme - etiology Erythema Multiforme - veterinary Erythema Multiforme - virology Female Foot Foot Ulcer - veterinary Foot Ulcer - virology Immunoenzyme Techniques - veterinary Keratinocytes - virology Necrosis Parvoviridae Infections - pathology Parvoviridae Infections - veterinary Parvovirus, Canine - isolation & purification Skin - pathology |
| title | Parvovirus Infection of Keratinocytes as a Cause of Canine Erythema Multiforme |
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