RAC-3 is a NF-κB coactivator

It has been shown that the molecular mechanism by which cytokines and glucocorticoids mutually antagonize their functions involves a mutual glucocorticoid receptor (GR)/nuclear factor-κB (NF-κB) transrepression. Here we report a role for the nuclear receptor coactivator RAC3, in modulating NF-κB tra...

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Veröffentlicht in:	FEBS letters 2000-11, Vol.485 (2), p.195-199
Hauptverfasser:	Werbajh, Santiago, Nojek, Ignacio, Lanz, Rainer, Costas, Mónica A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding, Competitive Glucocorticoid receptor Glucocorticoids - pharmacology HeLa Cells Humans Immunosorbent Techniques NF-kappa B - analysis NF-kappa B - metabolism Nuclear factor-κB Nuclear receptor coactivator Nuclear Receptor Coactivator 3 Receptors, Glucocorticoid - metabolism Response Elements Trans-Activators - genetics Trans-Activators - metabolism Trans-Activators - pharmacology Transcription Factor RelA Transcription Factors Transcription, Genetic Transfection Tumor necrosis factor Tumor Necrosis Factor-alpha - pharmacology
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