Activation of sphingolipid turnover and chronic generation of ceramide and sphingosine in liver during aging

Aging leads to a decreased ability of liver to metabolize drugs and increased expression and secretion of acute phase proteins, such as serum amyloid A (SAA), C-reactive protein (CRP), and alpha-1-acid glycoprotein (AGP). This phenomenon resembles some aspects of the acute phase response of host to...

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Veröffentlicht in:	Mechanisms of ageing and development 2000-12, Vol.120 (1), p.111-125
Hauptverfasser:	Lightle, Sandy A, Oakley, Jennifer I, Nikolova-Karakashian, Mariana N
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - genetics Aging - metabolism Amidohydrolases - metabolism Animals Aryl Hydrocarbon Hydroxylases Biological and medical sciences Ceramidases Ceramides - metabolism Cytochrome P-450 Enzyme System - genetics Down-Regulation Enzyme Activation Fundamental and applied biological sciences. Psychology In Vitro Techniques Kinetics Liver - metabolism Liver. Bile. Biliary tracts Male Rats Rats, Inbred F344 RNA, Messenger - genetics RNA, Messenger - metabolism Sphingolipids - metabolism Sphingomyelin Phosphodiesterase - metabolism Sphingosine - metabolism Steroid 16-alpha-Hydroxylase Steroid Hydroxylases - genetics Substrate Specificity Transferases (Other Substituted Phosphate Groups) - antagonists & inhibitors Vertebrates: digestive system
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