Perfusion-contraction mismatch with coronary microvascular obstruction: role of inflammation
1 Abteilungen für Pathophysiologie, 2 Hämatologie, und 3 Kardiologie, Zentrum für Innere Medizin des Universitätsklinikums, 45122 Essen, Germany A close relationship exists between regional myocardial blood flow (RMBF) and function during acute coronary inflow restriction (perfusion-contraction m...
Gespeichert in:
| Veröffentlicht in: | American journal of physiology. Heart and circulatory physiology 2000-12, Vol.279 (6), p.H2587-H2592 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | H2592 |
|---|---|
| container_issue | 6 |
| container_start_page | H2587 |
| container_title | American journal of physiology. Heart and circulatory physiology |
| container_volume | 279 |
| creator | Dorge, Hilmar Neumann, Till Behrends, Matthias Skyschally, Andreas Schulz, Rainer Kasper, Christoph Erbel, Raimund Heusch, Gerd |
| description | 1 Abteilungen für Pathophysiologie,
2 Hämatologie, und 3 Kardiologie, Zentrum
für Innere Medizin des Universitätsklinikums, 45122 Essen, Germany
A close relationship exists between
regional myocardial blood flow (RMBF) and function during acute
coronary inflow restriction (perfusion-contraction matching). However,
the relationship of flow and function during coronary microvascular
obstruction is unknown. In 12 anesthetized dogs, the left circumflex
coronary artery was perfused from an extracorporeal circuit. After
control measurements, 3,000 microspheres (42 µm diameter) per
milliliter per minute inflow were injected to cause a microembolism
(ME, n = 6). With unchanged systemic hemodynamics and
RMBF, posterior systolic wall thickening (PWT) decreased from 19.8 ± 1.9% SD at control to 13.3 ± 4.0, 10.3 ± 3.8, and
6.9 ± 4.7% ( P |
| doi_str_mv | 10.1152/ajpheart.2000.279.6.H2587 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72430476</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72430476</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-9fac3759110e58c5fbe52da99598e18f67d4e1ad8e14014686212dff92a9f8253</originalsourceid><addsrcrecordid>eNp1kE9P4zAQxa0Vq6UUvgIKF24JthMnMZxQxT8JaffA3layXMcmQU4cbAfot2doC_SyJ9vj92be_BA6ITgjhNEz-TS2WvqYUYxxRiueldktZXX1A83gn6aE5XwPzXBe5mlJcraPDkJ4AjGryvwX2icE1xXF9Qz9-6O9mULnhlS5IXqpItyTvgu9jKpNXrvYJsp5N0i_grLy7kUGNVnpE7cM0U9rw3nindWJM0k3GCt7MEP1EP000gZ9tD3n6O_11cPiNr3_fXO3uLxPVYFZTLmRKq8Yh1Sa1YqZpWa0kZwzXmtSm7JqCk1kA48Ck6KsS0poYwynkpuasnyOTjd9R--eJx2igPxKWysH7aYgKlrkuIDV54hvhLBGCF4bMfquh80EweIDrfhEKz7QCkArSrFGC97j7ZBp2evm27llCYKLjaDtHtvXzmsxtisga93jSlxP1j7ot_g1YKe1GBsD7rP_u79T7QR6Bx1IoJg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72430476</pqid></control><display><type>article</type><title>Perfusion-contraction mismatch with coronary microvascular obstruction: role of inflammation</title><source>MEDLINE</source><source>American Physiological Society Paid</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Dorge, Hilmar ; Neumann, Till ; Behrends, Matthias ; Skyschally, Andreas ; Schulz, Rainer ; Kasper, Christoph ; Erbel, Raimund ; Heusch, Gerd</creator><creatorcontrib>Dorge, Hilmar ; Neumann, Till ; Behrends, Matthias ; Skyschally, Andreas ; Schulz, Rainer ; Kasper, Christoph ; Erbel, Raimund ; Heusch, Gerd</creatorcontrib><description>1 Abteilungen für Pathophysiologie,
2 Hämatologie, und 3 Kardiologie, Zentrum
für Innere Medizin des Universitätsklinikums, 45122 Essen, Germany
A close relationship exists between
regional myocardial blood flow (RMBF) and function during acute
coronary inflow restriction (perfusion-contraction matching). However,
the relationship of flow and function during coronary microvascular
obstruction is unknown. In 12 anesthetized dogs, the left circumflex
coronary artery was perfused from an extracorporeal circuit. After
control measurements, 3,000 microspheres (42 µm diameter) per
milliliter per minute inflow were injected to cause a microembolism
(ME, n = 6). With unchanged systemic hemodynamics and
RMBF, posterior systolic wall thickening (PWT) decreased from 19.8 ± 1.9% SD at control to 13.3 ± 4.0, 10.3 ± 3.8, and
6.9 ± 4.7% ( P < 0.05 vs. control) at 1, 4, and
8 h, respectively. For comparison, inflow was progressively
reduced to match PWT to that of the ME group at 1, 4, and 8 h
(stenosis, STE, n = 6). RMBF in the STE group was
reduced in proportion to PWT. Infarct size was not different among
groups (6.5 ± 4.5 vs. 3.4 ± 3.2%). However, the number of leukocytes infiltrating the area at risk was significantly greater in
the ME group than in the STE group. Coronary microembolization results
in perfusion-contraction mismatch and is associated with an
inflammatory response.
microspheres; myocardial infarction; ischemia</description><identifier>ISSN: 0363-6135</identifier><identifier>EISSN: 1522-1539</identifier><identifier>DOI: 10.1152/ajpheart.2000.279.6.H2587</identifier><identifier>PMID: 11087208</identifier><language>eng</language><publisher>United States</publisher><subject>Anesthesia ; Animals ; Blood Pressure ; Chemotaxis, Leukocyte - immunology ; Coronary Circulation - immunology ; Dogs ; Embolism - immunology ; Embolism - pathology ; Embolism - physiopathology ; Heart Rate ; Leukocyte Count ; Leukocytes - cytology ; Leukocytes - immunology ; Macrophages - cytology ; Macrophages - immunology ; Microcirculation - immunology ; Microspheres ; Monocytes - cytology ; Monocytes - immunology ; Myocardial Contraction - immunology ; Myocardial Stunning - immunology ; Myocardial Stunning - pathology ; Myocardial Stunning - physiopathology ; Myocarditis - immunology ; Myocarditis - pathology ; Myocarditis - physiopathology ; Pericardium - immunology ; Pericardium - pathology ; Pericardium - physiopathology</subject><ispartof>American journal of physiology. Heart and circulatory physiology, 2000-12, Vol.279 (6), p.H2587-H2592</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-9fac3759110e58c5fbe52da99598e18f67d4e1ad8e14014686212dff92a9f8253</citedby><cites>FETCH-LOGICAL-c405t-9fac3759110e58c5fbe52da99598e18f67d4e1ad8e14014686212dff92a9f8253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3026,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11087208$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dorge, Hilmar</creatorcontrib><creatorcontrib>Neumann, Till</creatorcontrib><creatorcontrib>Behrends, Matthias</creatorcontrib><creatorcontrib>Skyschally, Andreas</creatorcontrib><creatorcontrib>Schulz, Rainer</creatorcontrib><creatorcontrib>Kasper, Christoph</creatorcontrib><creatorcontrib>Erbel, Raimund</creatorcontrib><creatorcontrib>Heusch, Gerd</creatorcontrib><title>Perfusion-contraction mismatch with coronary microvascular obstruction: role of inflammation</title><title>American journal of physiology. Heart and circulatory physiology</title><addtitle>Am J Physiol Heart Circ Physiol</addtitle><description>1 Abteilungen für Pathophysiologie,
2 Hämatologie, und 3 Kardiologie, Zentrum
für Innere Medizin des Universitätsklinikums, 45122 Essen, Germany
A close relationship exists between
regional myocardial blood flow (RMBF) and function during acute
coronary inflow restriction (perfusion-contraction matching). However,
the relationship of flow and function during coronary microvascular
obstruction is unknown. In 12 anesthetized dogs, the left circumflex
coronary artery was perfused from an extracorporeal circuit. After
control measurements, 3,000 microspheres (42 µm diameter) per
milliliter per minute inflow were injected to cause a microembolism
(ME, n = 6). With unchanged systemic hemodynamics and
RMBF, posterior systolic wall thickening (PWT) decreased from 19.8 ± 1.9% SD at control to 13.3 ± 4.0, 10.3 ± 3.8, and
6.9 ± 4.7% ( P < 0.05 vs. control) at 1, 4, and
8 h, respectively. For comparison, inflow was progressively
reduced to match PWT to that of the ME group at 1, 4, and 8 h
(stenosis, STE, n = 6). RMBF in the STE group was
reduced in proportion to PWT. Infarct size was not different among
groups (6.5 ± 4.5 vs. 3.4 ± 3.2%). However, the number of leukocytes infiltrating the area at risk was significantly greater in
the ME group than in the STE group. Coronary microembolization results
in perfusion-contraction mismatch and is associated with an
inflammatory response.
microspheres; myocardial infarction; ischemia</description><subject>Anesthesia</subject><subject>Animals</subject><subject>Blood Pressure</subject><subject>Chemotaxis, Leukocyte - immunology</subject><subject>Coronary Circulation - immunology</subject><subject>Dogs</subject><subject>Embolism - immunology</subject><subject>Embolism - pathology</subject><subject>Embolism - physiopathology</subject><subject>Heart Rate</subject><subject>Leukocyte Count</subject><subject>Leukocytes - cytology</subject><subject>Leukocytes - immunology</subject><subject>Macrophages - cytology</subject><subject>Macrophages - immunology</subject><subject>Microcirculation - immunology</subject><subject>Microspheres</subject><subject>Monocytes - cytology</subject><subject>Monocytes - immunology</subject><subject>Myocardial Contraction - immunology</subject><subject>Myocardial Stunning - immunology</subject><subject>Myocardial Stunning - pathology</subject><subject>Myocardial Stunning - physiopathology</subject><subject>Myocarditis - immunology</subject><subject>Myocarditis - pathology</subject><subject>Myocarditis - physiopathology</subject><subject>Pericardium - immunology</subject><subject>Pericardium - pathology</subject><subject>Pericardium - physiopathology</subject><issn>0363-6135</issn><issn>1522-1539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE9P4zAQxa0Vq6UUvgIKF24JthMnMZxQxT8JaffA3layXMcmQU4cbAfot2doC_SyJ9vj92be_BA6ITgjhNEz-TS2WvqYUYxxRiueldktZXX1A83gn6aE5XwPzXBe5mlJcraPDkJ4AjGryvwX2icE1xXF9Qz9-6O9mULnhlS5IXqpItyTvgu9jKpNXrvYJsp5N0i_grLy7kUGNVnpE7cM0U9rw3nindWJM0k3GCt7MEP1EP000gZ9tD3n6O_11cPiNr3_fXO3uLxPVYFZTLmRKq8Yh1Sa1YqZpWa0kZwzXmtSm7JqCk1kA48Ck6KsS0poYwynkpuasnyOTjd9R--eJx2igPxKWysH7aYgKlrkuIDV54hvhLBGCF4bMfquh80EweIDrfhEKz7QCkArSrFGC97j7ZBp2evm27llCYKLjaDtHtvXzmsxtisga93jSlxP1j7ot_g1YKe1GBsD7rP_u79T7QR6Bx1IoJg</recordid><startdate>20001201</startdate><enddate>20001201</enddate><creator>Dorge, Hilmar</creator><creator>Neumann, Till</creator><creator>Behrends, Matthias</creator><creator>Skyschally, Andreas</creator><creator>Schulz, Rainer</creator><creator>Kasper, Christoph</creator><creator>Erbel, Raimund</creator><creator>Heusch, Gerd</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20001201</creationdate><title>Perfusion-contraction mismatch with coronary microvascular obstruction: role of inflammation</title><author>Dorge, Hilmar ; Neumann, Till ; Behrends, Matthias ; Skyschally, Andreas ; Schulz, Rainer ; Kasper, Christoph ; Erbel, Raimund ; Heusch, Gerd</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-9fac3759110e58c5fbe52da99598e18f67d4e1ad8e14014686212dff92a9f8253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Anesthesia</topic><topic>Animals</topic><topic>Blood Pressure</topic><topic>Chemotaxis, Leukocyte - immunology</topic><topic>Coronary Circulation - immunology</topic><topic>Dogs</topic><topic>Embolism - immunology</topic><topic>Embolism - pathology</topic><topic>Embolism - physiopathology</topic><topic>Heart Rate</topic><topic>Leukocyte Count</topic><topic>Leukocytes - cytology</topic><topic>Leukocytes - immunology</topic><topic>Macrophages - cytology</topic><topic>Macrophages - immunology</topic><topic>Microcirculation - immunology</topic><topic>Microspheres</topic><topic>Monocytes - cytology</topic><topic>Monocytes - immunology</topic><topic>Myocardial Contraction - immunology</topic><topic>Myocardial Stunning - immunology</topic><topic>Myocardial Stunning - pathology</topic><topic>Myocardial Stunning - physiopathology</topic><topic>Myocarditis - immunology</topic><topic>Myocarditis - pathology</topic><topic>Myocarditis - physiopathology</topic><topic>Pericardium - immunology</topic><topic>Pericardium - pathology</topic><topic>Pericardium - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dorge, Hilmar</creatorcontrib><creatorcontrib>Neumann, Till</creatorcontrib><creatorcontrib>Behrends, Matthias</creatorcontrib><creatorcontrib>Skyschally, Andreas</creatorcontrib><creatorcontrib>Schulz, Rainer</creatorcontrib><creatorcontrib>Kasper, Christoph</creatorcontrib><creatorcontrib>Erbel, Raimund</creatorcontrib><creatorcontrib>Heusch, Gerd</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dorge, Hilmar</au><au>Neumann, Till</au><au>Behrends, Matthias</au><au>Skyschally, Andreas</au><au>Schulz, Rainer</au><au>Kasper, Christoph</au><au>Erbel, Raimund</au><au>Heusch, Gerd</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Perfusion-contraction mismatch with coronary microvascular obstruction: role of inflammation</atitle><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle><addtitle>Am J Physiol Heart Circ Physiol</addtitle><date>2000-12-01</date><risdate>2000</risdate><volume>279</volume><issue>6</issue><spage>H2587</spage><epage>H2592</epage><pages>H2587-H2592</pages><issn>0363-6135</issn><eissn>1522-1539</eissn><abstract>1 Abteilungen für Pathophysiologie,
2 Hämatologie, und 3 Kardiologie, Zentrum
für Innere Medizin des Universitätsklinikums, 45122 Essen, Germany
A close relationship exists between
regional myocardial blood flow (RMBF) and function during acute
coronary inflow restriction (perfusion-contraction matching). However,
the relationship of flow and function during coronary microvascular
obstruction is unknown. In 12 anesthetized dogs, the left circumflex
coronary artery was perfused from an extracorporeal circuit. After
control measurements, 3,000 microspheres (42 µm diameter) per
milliliter per minute inflow were injected to cause a microembolism
(ME, n = 6). With unchanged systemic hemodynamics and
RMBF, posterior systolic wall thickening (PWT) decreased from 19.8 ± 1.9% SD at control to 13.3 ± 4.0, 10.3 ± 3.8, and
6.9 ± 4.7% ( P < 0.05 vs. control) at 1, 4, and
8 h, respectively. For comparison, inflow was progressively
reduced to match PWT to that of the ME group at 1, 4, and 8 h
(stenosis, STE, n = 6). RMBF in the STE group was
reduced in proportion to PWT. Infarct size was not different among
groups (6.5 ± 4.5 vs. 3.4 ± 3.2%). However, the number of leukocytes infiltrating the area at risk was significantly greater in
the ME group than in the STE group. Coronary microembolization results
in perfusion-contraction mismatch and is associated with an
inflammatory response.
microspheres; myocardial infarction; ischemia</abstract><cop>United States</cop><pmid>11087208</pmid><doi>10.1152/ajpheart.2000.279.6.H2587</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0363-6135 |
| ispartof | American journal of physiology. Heart and circulatory physiology, 2000-12, Vol.279 (6), p.H2587-H2592 |
| issn | 0363-6135 1522-1539 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72430476 |
| source | MEDLINE; American Physiological Society Paid; EZB-FREE-00999 freely available EZB journals |
| subjects | Anesthesia Animals Blood Pressure Chemotaxis, Leukocyte - immunology Coronary Circulation - immunology Dogs Embolism - immunology Embolism - pathology Embolism - physiopathology Heart Rate Leukocyte Count Leukocytes - cytology Leukocytes - immunology Macrophages - cytology Macrophages - immunology Microcirculation - immunology Microspheres Monocytes - cytology Monocytes - immunology Myocardial Contraction - immunology Myocardial Stunning - immunology Myocardial Stunning - pathology Myocardial Stunning - physiopathology Myocarditis - immunology Myocarditis - pathology Myocarditis - physiopathology Pericardium - immunology Pericardium - pathology Pericardium - physiopathology |
| title | Perfusion-contraction mismatch with coronary microvascular obstruction: role of inflammation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T23%3A22%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Perfusion-contraction%20mismatch%20with%20coronary%20microvascular%20obstruction:%20role%20of%20inflammation&rft.jtitle=American%20journal%20of%20physiology.%20Heart%20and%20circulatory%20physiology&rft.au=Dorge,%20Hilmar&rft.date=2000-12-01&rft.volume=279&rft.issue=6&rft.spage=H2587&rft.epage=H2592&rft.pages=H2587-H2592&rft.issn=0363-6135&rft.eissn=1522-1539&rft_id=info:doi/10.1152/ajpheart.2000.279.6.H2587&rft_dat=%3Cproquest_cross%3E72430476%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=72430476&rft_id=info:pmid/11087208&rfr_iscdi=true |