Restless legs syndrome in monozygotic twins : Clinical correlates
To better understand genetic characteristics of restless legs syndrome (RLS) and identify nongenetic factors that may influence phenotype, the authors studied 12 identical twins in which at least one member expressed RLS. Ten of the 12 twin pairs were concordant for RLS symptoms. Despite the high co...
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| Veröffentlicht in: | Neurology 2000-11, Vol.55 (9), p.1404-1406 |
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| creator | ONDO, William G VUONG, Kevin Dat QING WANG |
| description | To better understand genetic characteristics of restless legs syndrome (RLS) and identify nongenetic factors that may influence phenotype, the authors studied 12 identical twins in which at least one member expressed RLS. Ten of the 12 twin pairs were concordant for RLS symptoms. Despite the high concordance rate, the disease severity, age at onset, and symptom descriptions often varied between twins. Birth order, birth weight, and serum ferritin levels did not predict RLS severity or age at onset. |
| doi_str_mv | 10.1212/WNL.55.9.1404 |
| format | Article |
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Ten of the 12 twin pairs were concordant for RLS symptoms. Despite the high concordance rate, the disease severity, age at onset, and symptom descriptions often varied between twins. Birth order, birth weight, and serum ferritin levels did not predict RLS severity or age at onset.</description><identifier>ISSN: 0028-3878</identifier><identifier>EISSN: 1526-632X</identifier><identifier>DOI: 10.1212/WNL.55.9.1404</identifier><identifier>PMID: 11087794</identifier><identifier>CODEN: NEURAI</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Diseases in Twins - genetics ; Female ; Genotype ; Humans ; Male ; Medical sciences ; Middle Aged ; Nervous system (semeiology, syndromes) ; Nervous system as a whole ; Neurology ; Restless Legs Syndrome - genetics ; Restless Legs Syndrome - physiopathology</subject><ispartof>Neurology, 2000-11, Vol.55 (9), p.1404-1406</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-94624c9dd094e5b6eb897282239c3e714123074031ea3c41fe7e26bb0e68b1b13</citedby><cites>FETCH-LOGICAL-c361t-94624c9dd094e5b6eb897282239c3e714123074031ea3c41fe7e26bb0e68b1b13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=795892$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11087794$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ONDO, William G</creatorcontrib><creatorcontrib>VUONG, Kevin Dat</creatorcontrib><creatorcontrib>QING WANG</creatorcontrib><title>Restless legs syndrome in monozygotic twins : Clinical correlates</title><title>Neurology</title><addtitle>Neurology</addtitle><description>To better understand genetic characteristics of restless legs syndrome (RLS) and identify nongenetic factors that may influence phenotype, the authors studied 12 identical twins in which at least one member expressed RLS. 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Birth order, birth weight, and serum ferritin levels did not predict RLS severity or age at onset.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Diseases in Twins - genetics</subject><subject>Female</subject><subject>Genotype</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Nervous system as a whole</subject><subject>Neurology</subject><subject>Restless Legs Syndrome - genetics</subject><subject>Restless Legs Syndrome - physiopathology</subject><issn>0028-3878</issn><issn>1526-632X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0E1Lw0AQBuBFFFurR68SELwl7leyWW-l-AVFQRS9LclmUiKbbN1JkfrrTWnQ0xzm4WXmJeSc0YRxxq_fn5ZJmiY6YZLKAzJlKc_iTPCPQzKllOexyFU-ISeIn5QOS6WPyYQxmiul5ZTMXwB7B4iRgxVGuO2q4FuImi5qfed_tivfNzbqv5sOo5to4ZqusYWLrA8BXNEDnpKjunAIZ-Ockbe729fFQ7x8vn9czJexFRnrYy0zLq2uKqolpGUGZa4VzzkX2gpQTDIuqJJUMCiElawGBTwrSwpZXrKSiRm52ueug__aDFebtkELzhUd-A0axaWgkuoBxntog0cMUJt1aNoibA2jZteZGTozaWq02XU2-IsxeFO2UP3rsaQBXI6gwOH3OhSdbfDPKZ3mmotfl1xy3Q</recordid><startdate>20001114</startdate><enddate>20001114</enddate><creator>ONDO, William G</creator><creator>VUONG, Kevin Dat</creator><creator>QING WANG</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20001114</creationdate><title>Restless legs syndrome in monozygotic twins : Clinical correlates</title><author>ONDO, William G ; VUONG, Kevin Dat ; QING WANG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-94624c9dd094e5b6eb897282239c3e714123074031ea3c41fe7e26bb0e68b1b13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Diseases in Twins - genetics</topic><topic>Female</topic><topic>Genotype</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Nervous system as a whole</topic><topic>Neurology</topic><topic>Restless Legs Syndrome - genetics</topic><topic>Restless Legs Syndrome - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ONDO, William G</creatorcontrib><creatorcontrib>VUONG, Kevin Dat</creatorcontrib><creatorcontrib>QING WANG</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ONDO, William G</au><au>VUONG, Kevin Dat</au><au>QING WANG</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Restless legs syndrome in monozygotic twins : Clinical correlates</atitle><jtitle>Neurology</jtitle><addtitle>Neurology</addtitle><date>2000-11-14</date><risdate>2000</risdate><volume>55</volume><issue>9</issue><spage>1404</spage><epage>1406</epage><pages>1404-1406</pages><issn>0028-3878</issn><eissn>1526-632X</eissn><coden>NEURAI</coden><abstract>To better understand genetic characteristics of restless legs syndrome (RLS) and identify nongenetic factors that may influence phenotype, the authors studied 12 identical twins in which at least one member expressed RLS. 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| ispartof | Neurology, 2000-11, Vol.55 (9), p.1404-1406 |
| issn | 0028-3878 1526-632X |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Adult Aged Biological and medical sciences Diseases in Twins - genetics Female Genotype Humans Male Medical sciences Middle Aged Nervous system (semeiology, syndromes) Nervous system as a whole Neurology Restless Legs Syndrome - genetics Restless Legs Syndrome - physiopathology |
| title | Restless legs syndrome in monozygotic twins : Clinical correlates |
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