Role of graft interleukin-10 expression in the tolerogenicity of neonatal skin allografts

Allografts of skin from neonatal donors survive longer than those from adult donors and can induce tolerance in mice that are treated with short-term immunosuppression. Neonatal (< or =24 hr old) epidermal cells (EPC) secrete high levels of interleukin-(IL) 10 and include abundant class II- immat...

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Veröffentlicht in:	Transplantation 2000-11, Vol.70 (9), p.1371-1377
Hauptverfasser:	DE FAZIO, Sally R, GOZZO, James J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn B7-1 Antigen - biosynthesis Biological and medical sciences Bone Marrow Cells - immunology Graft Survival - drug effects Graft Survival - immunology Histocompatibility Antigens Class II - biosynthesis Immune Tolerance - drug effects Interleukin-10 - physiology Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Skin - immunology Skin - metabolism Skin plastic surgery Skin Transplantation - immunology Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
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