Sterol Regulatory Element-Binding Protein-1 Participates in the Regulation of Fatty Acid Synthase Expression in Colorectal Neoplasia

Endogenous fatty acid synthesis has been observed in certain rapidly proliferating normal and neoplastic tissues. Sterol regulatory element-binding proteins (SREBPs) are transcription factors that regulate the expression of lipogenic genes including fatty acid synthase (FAS), the major biosynthetic...

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Veröffentlicht in:	Experimental cell research 2000-11, Vol.261 (1), p.159-165
Hauptverfasser:	Li, Ji Nong, Mahmoud, Moushira A., Han, Wan Fang, Ripple, Mary, Pizer, Ellen S.
Format:	Artikel
Sprache:	eng
Schlagworte:	CCAAT-Enhancer-Binding Proteins - metabolism Cell Division Cerulenin - pharmacology Colonic Neoplasms - enzymology Colonic Neoplasms - genetics colorectal carcinoma Colorectal Neoplasms - enzymology Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Colorectal Neoplasms - surgery DNA-Binding Proteins - metabolism fas Receptor - genetics fatty acid synthase Fatty Acid Synthases - genetics Furans - pharmacology Gene Expression Regulation, Enzymologic - drug effects Gene Expression Regulation, Neoplastic - drug effects Humans Hypolipidemic Agents - pharmacology Ki-67 Antigen - genetics Mitotic Index Promoter Regions, Genetic - drug effects Recombinant Fusion Proteins - biosynthesis Sterol Regulatory Element Binding Protein 1 sterol regulatory element-binding protein transcription Transcription Factors - metabolism Transfection Tumor Cells, Cultured
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