Severely impaired baroreflex-buffering in patients with monogenic hypertension and neurovascular contact

We identified a family with a monogenic syndrome of hypertension, brachydactyly, and neurovascular contact of the brain stem. Neurovascular contact of the ventrolateral medulla may lead to arterial hypertension by interfering with baroreflex function. In 5 patients with monogenic hypertension (18 to...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2000-11, Vol.102 (21), p.2611-2618
Hauptverfasser:	JORDAN, Jens, TOKA, Hakan R, OELKERS, Wolfgang, SCHUSTER, Herbert, SCHOBEL, Hans P, HALLER, Hermann, LUFT, Friedrich C, HEUSSER, Karsten, TOKA, Okan, SHANNON, John R, TANK, Jens, DIEDRICH, Andre, STABROTH, Christine, STOFFELS, Mandy, NARAGHI, Ramin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Arterial hypertension. Arterial hypotension Baroreflex - drug effects Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Brain Stem - abnormalities Brain Stem - blood supply Brain Stem - physiopathology Cardiology. Vascular system Cerebellum - blood supply Cerebral Arteries - abnormalities Clinical manifestations. Epidemiology. Investigative techniques. Etiology Cold Temperature Electrophysiology Fingers - abnormalities Ganglionic Blockers - pharmacology Genes, Dominant Heart Rate - drug effects Humans Hypertension - complications Hypertension - diagnosis Hypertension - genetics Hypertension - physiopathology Magnetic Resonance Imaging Medical sciences Phenylephrine - pharmacology Posture Pressoreceptors - drug effects Syndrome Valsalva Maneuver Vasoconstrictor Agents - pharmacology Vasodilator Agents - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	We identified a family with a monogenic syndrome of hypertension, brachydactyly, and neurovascular contact of the brain stem. Neurovascular contact of the ventrolateral medulla may lead to arterial hypertension by interfering with baroreflex function. In 5 patients with monogenic hypertension (18 to 34 years old), we conducted detailed autonomic function tests. Blood pressure during complete ganglionic blockade was 134+/-4.9/82+/-4.1 mm Hg and 90+/-6/49+/-2.4 mm Hg in patients and in control subjects, respectively. During ganglionic blockade, plasma vasopressin concentration increased 24-fold in control subjects and
ISSN:	0009-7322 1524-4539
DOI:	10.1161/01.CIR.102.21.2611