Multidrug resistance in brain tumors: roles of the blood-brain barrier

Malignant brain tumors and brain metastases present a formidable clinical challenge against which no significant advances have been made over the last decade. Multidrug resistance (MDR) is one of the main factors in the failure of chemotherapy against central nervous system tumors. The MDR1 gene enc...

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Veröffentlicht in:	Cancer and metastasis reviews 2001-01, Vol.20 (1-2), p.13-25
Hauptverfasser:	Régina, A, Demeule, M, Laplante, A, Jodoin, J, Dagenais, C, Berthelet, F, Moghrabi, A, Béliveau, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - therapeutic use ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Blood-Brain Barrier Brain cancer Brain Neoplasms - drug therapy Brain Neoplasms - metabolism Chemotherapy Drug resistance Drug Resistance, Multiple Drug Resistance, Neoplasm Humans Multidrug Resistance-Associated Proteins - metabolism Treatment
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