Antioxidant Properties of Rimantadine in Influenza Virus Infected Mice and in Some Model Systems
Influenza virus infection is associated with development of oxidative stress in lung and blood plasma, viz. increase of primary and secondary lipid peroxidation products. It was established that rimantadine treatment led to a decrease of the products of lipid peroxidation in tissues of mice experime...
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description | Influenza virus infection is associated with development of oxidative stress in lung and blood plasma, viz. increase of primary and secondary lipid peroxidation products. It was established that rimantadine treatment led to a decrease of the products of lipid peroxidation in tissues of mice experimentally infected with influenza virus A/Aichi/2/68 (H3N2). The effect is strongest in blood plasma (a decrease of about 50%) and weaker in the lung (about 20%). To elucidate the mechanism of this action of rimantadine, experiments were carried out with some model systems. The capability of rimantadine to scavenge superoxide radicals (scavenging properties) was studied in a system of xanthine-xanthine oxidase to generate superoxide. The amount of superoxide was measured spectrophotometrically by the NBT-test and chemiluminesce. Rimantadine does not show scavenging properties and its antioxidant effect observed in vivo, is not a result of its direct action on the processes of lipid peroxidation and/or interaction with antioxidant enzymes. The antioxidant properties of rimantadine were investigated by measurement of induced lipid peroxidation in a Fe
and (Fe
- EDTA) system with an egg liposomal suspension. Our findings with model systems do not prove an antioxidant or prooxidant effect of the drug on the processes of lipid peroxidation. Apparently, the observed antioxidant effect of rimantadine in vivo is not connected directly with free radical processes in the organism. |
doi_str_mv | 10.1515/znc-2000-9-1025 |
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and (Fe
- EDTA) system with an egg liposomal suspension. Our findings with model systems do not prove an antioxidant or prooxidant effect of the drug on the processes of lipid peroxidation. Apparently, the observed antioxidant effect of rimantadine in vivo is not connected directly with free radical processes in the organism.</description><identifier>ISSN: 0939-5075</identifier><identifier>EISSN: 1865-7125</identifier><identifier>DOI: 10.1515/znc-2000-9-1025</identifier><identifier>PMID: 11098838</identifier><language>eng</language><publisher>Germany: Verlag der Zeitschrift für Naturforschung</publisher><subject>Animals ; Antioxidants - pharmacology ; Free Radical Scavengers - pharmacology ; Influenza A virus ; Lipid Peroxidation - drug effects ; Lung - drug effects ; Lung - physiology ; Lung - physiopathology ; Male ; Mice ; Mice, Inbred ICR ; Orthomyxoviridae Infections - blood ; Orthomyxoviridae Infections - physiopathology ; Rats ; Rats, Wistar ; Rimantadine - pharmacology ; Rimantadine. Lipid Peroxidation. Scavenger ; Superoxides - metabolism ; Thiobarbituric Acid Reactive Substances - analysis ; Xanthine ; Xanthine Oxidase</subject><ispartof>Zeitschrift für Naturforschung C. A journal of biosciences, 2000-09, Vol.55 (9), p.824-829</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-18b6491562211e1c809cf6834191a871d42e2bc22c2e25d8c0afb582327313d83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11098838$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mileva, Milka</creatorcontrib><creatorcontrib>Hadjimitova, Vera</creatorcontrib><creatorcontrib>Tantcheva, Lubka</creatorcontrib><creatorcontrib>Traykov, Trayko</creatorcontrib><creatorcontrib>Galabov, Angel S.</creatorcontrib><creatorcontrib>Savov, Varban</creatorcontrib><creatorcontrib>Ribarov, Stefan</creatorcontrib><title>Antioxidant Properties of Rimantadine in Influenza Virus Infected Mice and in Some Model Systems</title><title>Zeitschrift für Naturforschung C. A journal of biosciences</title><addtitle>Z Naturforsch C</addtitle><description>Influenza virus infection is associated with development of oxidative stress in lung and blood plasma, viz. increase of primary and secondary lipid peroxidation products. It was established that rimantadine treatment led to a decrease of the products of lipid peroxidation in tissues of mice experimentally infected with influenza virus A/Aichi/2/68 (H3N2). The effect is strongest in blood plasma (a decrease of about 50%) and weaker in the lung (about 20%). To elucidate the mechanism of this action of rimantadine, experiments were carried out with some model systems. The capability of rimantadine to scavenge superoxide radicals (scavenging properties) was studied in a system of xanthine-xanthine oxidase to generate superoxide. The amount of superoxide was measured spectrophotometrically by the NBT-test and chemiluminesce. Rimantadine does not show scavenging properties and its antioxidant effect observed in vivo, is not a result of its direct action on the processes of lipid peroxidation and/or interaction with antioxidant enzymes. The antioxidant properties of rimantadine were investigated by measurement of induced lipid peroxidation in a Fe
and (Fe
- EDTA) system with an egg liposomal suspension. Our findings with model systems do not prove an antioxidant or prooxidant effect of the drug on the processes of lipid peroxidation. Apparently, the observed antioxidant effect of rimantadine in vivo is not connected directly with free radical processes in the organism.</description><subject>Animals</subject><subject>Antioxidants - pharmacology</subject><subject>Free Radical Scavengers - pharmacology</subject><subject>Influenza A virus</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Lung - drug effects</subject><subject>Lung - physiology</subject><subject>Lung - physiopathology</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Orthomyxoviridae Infections - blood</subject><subject>Orthomyxoviridae Infections - physiopathology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rimantadine - pharmacology</subject><subject>Rimantadine. Lipid Peroxidation. Scavenger</subject><subject>Superoxides - metabolism</subject><subject>Thiobarbituric Acid Reactive Substances - analysis</subject><subject>Xanthine</subject><subject>Xanthine Oxidase</subject><issn>0939-5075</issn><issn>1865-7125</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1P3DAQhi1UBFvgzK3yqbcUjx0n9g2E-oEEKgLaq-u1J5VRYi92orL8-ibalXrq6fVYz7zSPIScA_sEEuTFW3QVZ4xVugLG5QFZgWpk1QKX78iKaaEryVp5TN6X8syYaGQrj8gxANNKCbUiv67iGNJr8DaO9D6nDeYxYKGpow9hmD-tDxFpiPQmdv2E8c3SnyFPZZnRjejpXXBIbfQL9JgGpHfJY08ft2XEoZySw872Bc_2eUJ-fPn8dP2tuv3-9eb66rZyQsNYgVo3tQbZcA6A4BTTrmuUqEGDVS34miNfO87dnNIrx2y3looL3goQXokT8nHXu8npZcIymiEUh31vI6apmJbXvK31Al7sQJdTKRk7s8nzpXlrgJlFqpmlmkWq0WaROm982FdP6wH9P35vcQYud8Af24-YPf7O03Z-mOc05Thf_b9qKZdUvBZ_AZJthuk</recordid><startdate>20000901</startdate><enddate>20000901</enddate><creator>Mileva, Milka</creator><creator>Hadjimitova, Vera</creator><creator>Tantcheva, Lubka</creator><creator>Traykov, Trayko</creator><creator>Galabov, Angel S.</creator><creator>Savov, Varban</creator><creator>Ribarov, Stefan</creator><general>Verlag der Zeitschrift für Naturforschung</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000901</creationdate><title>Antioxidant Properties of Rimantadine in Influenza Virus Infected Mice and in Some Model Systems</title><author>Mileva, Milka ; Hadjimitova, Vera ; Tantcheva, Lubka ; Traykov, Trayko ; Galabov, Angel S. ; Savov, Varban ; Ribarov, Stefan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-18b6491562211e1c809cf6834191a871d42e2bc22c2e25d8c0afb582327313d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Antioxidants - pharmacology</topic><topic>Free Radical Scavengers - pharmacology</topic><topic>Influenza A virus</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Lung - drug effects</topic><topic>Lung - physiology</topic><topic>Lung - physiopathology</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Orthomyxoviridae Infections - blood</topic><topic>Orthomyxoviridae Infections - physiopathology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rimantadine - pharmacology</topic><topic>Rimantadine. Lipid Peroxidation. Scavenger</topic><topic>Superoxides - metabolism</topic><topic>Thiobarbituric Acid Reactive Substances - analysis</topic><topic>Xanthine</topic><topic>Xanthine Oxidase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mileva, Milka</creatorcontrib><creatorcontrib>Hadjimitova, Vera</creatorcontrib><creatorcontrib>Tantcheva, Lubka</creatorcontrib><creatorcontrib>Traykov, Trayko</creatorcontrib><creatorcontrib>Galabov, Angel S.</creatorcontrib><creatorcontrib>Savov, Varban</creatorcontrib><creatorcontrib>Ribarov, Stefan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Zeitschrift für Naturforschung C. A journal of biosciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mileva, Milka</au><au>Hadjimitova, Vera</au><au>Tantcheva, Lubka</au><au>Traykov, Trayko</au><au>Galabov, Angel S.</au><au>Savov, Varban</au><au>Ribarov, Stefan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antioxidant Properties of Rimantadine in Influenza Virus Infected Mice and in Some Model Systems</atitle><jtitle>Zeitschrift für Naturforschung C. A journal of biosciences</jtitle><addtitle>Z Naturforsch C</addtitle><date>2000-09-01</date><risdate>2000</risdate><volume>55</volume><issue>9</issue><spage>824</spage><epage>829</epage><pages>824-829</pages><issn>0939-5075</issn><eissn>1865-7125</eissn><abstract>Influenza virus infection is associated with development of oxidative stress in lung and blood plasma, viz. increase of primary and secondary lipid peroxidation products. It was established that rimantadine treatment led to a decrease of the products of lipid peroxidation in tissues of mice experimentally infected with influenza virus A/Aichi/2/68 (H3N2). The effect is strongest in blood plasma (a decrease of about 50%) and weaker in the lung (about 20%). To elucidate the mechanism of this action of rimantadine, experiments were carried out with some model systems. The capability of rimantadine to scavenge superoxide radicals (scavenging properties) was studied in a system of xanthine-xanthine oxidase to generate superoxide. The amount of superoxide was measured spectrophotometrically by the NBT-test and chemiluminesce. Rimantadine does not show scavenging properties and its antioxidant effect observed in vivo, is not a result of its direct action on the processes of lipid peroxidation and/or interaction with antioxidant enzymes. The antioxidant properties of rimantadine were investigated by measurement of induced lipid peroxidation in a Fe
and (Fe
- EDTA) system with an egg liposomal suspension. Our findings with model systems do not prove an antioxidant or prooxidant effect of the drug on the processes of lipid peroxidation. Apparently, the observed antioxidant effect of rimantadine in vivo is not connected directly with free radical processes in the organism.</abstract><cop>Germany</cop><pub>Verlag der Zeitschrift für Naturforschung</pub><pmid>11098838</pmid><doi>10.1515/znc-2000-9-1025</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Animals Antioxidants - pharmacology Free Radical Scavengers - pharmacology Influenza A virus Lipid Peroxidation - drug effects Lung - drug effects Lung - physiology Lung - physiopathology Male Mice Mice, Inbred ICR Orthomyxoviridae Infections - blood Orthomyxoviridae Infections - physiopathology Rats Rats, Wistar Rimantadine - pharmacology Rimantadine. Lipid Peroxidation. Scavenger Superoxides - metabolism Thiobarbituric Acid Reactive Substances - analysis Xanthine Xanthine Oxidase |
title | Antioxidant Properties of Rimantadine in Influenza Virus Infected Mice and in Some Model Systems |
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