Transcranial ultrasound-improved thrombolysis: diagnostic vs. therapeutic ultrasound
Success of stroke treatment with rt-PA depends on rapid vessel recanalization. Enzymatic thrombolysis may be enhanced by additional transcranial application of ultrasound (US). We investigated this novel technique using a 185-kHz probe and compared it to standard diagnostic US. In vitro studies were...
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| Veröffentlicht in: | Ultrasound in medicine & biology 2001-12, Vol.27 (12), p.1683-1689 |
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| creator | Behrens, Stephan Spengos, Konstantinos Daffertshofer, Michael Schroeck, Helmut Dempfle, Carl E Hennerici, Michael |
| description | Success of stroke treatment with rt-PA depends on rapid vessel recanalization. Enzymatic thrombolysis may be enhanced by additional transcranial application of ultrasound (US). We investigated this novel technique using a 185-kHz probe and compared it to standard diagnostic US.
In vitro studies were performed in a continuous pressure tubing system. Clots were placed in a postmortem skull and treated with rt-PA together with or without transtemporal 185-kHz US insonation (2W/cm
2) and in comparison to 1-MHz diagnostic US (0.5 W/cm
2). Recanalization time was significantly (
p < 0.01) shorter in the 185-kHz (14.1 min) and 1-MHz (17.1 min) US rt-PA treatment group compared to rt-PA treatment alone (29.3 min.). Flow rate was significantly higher (
p < 0.025) and increased faster in the combined treatment group with rt-PA + 185-kHz US compared to rt-PA + 1-MHz US. We investigated the blood-brain barrier in rats after 90-min exposure time of the brain with 185-kHz US, but no damage was observed. Results suggest efficacy and safety of the 185-kHz transducer, which is superior to diagnostic US. Such a novel US probe may be able to optimize thrombolytic stroke treatment. (E-mail: hennerici@neuro.ma.uni-heidelberg.de) |
| doi_str_mv | 10.1016/S0301-5629(01)00481-1 |
| format | Article |
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In vitro studies were performed in a continuous pressure tubing system. Clots were placed in a postmortem skull and treated with rt-PA together with or without transtemporal 185-kHz US insonation (2W/cm
2) and in comparison to 1-MHz diagnostic US (0.5 W/cm
2). Recanalization time was significantly (
p < 0.01) shorter in the 185-kHz (14.1 min) and 1-MHz (17.1 min) US rt-PA treatment group compared to rt-PA treatment alone (29.3 min.). Flow rate was significantly higher (
p < 0.025) and increased faster in the combined treatment group with rt-PA + 185-kHz US compared to rt-PA + 1-MHz US. We investigated the blood-brain barrier in rats after 90-min exposure time of the brain with 185-kHz US, but no damage was observed. Results suggest efficacy and safety of the 185-kHz transducer, which is superior to diagnostic US. Such a novel US probe may be able to optimize thrombolytic stroke treatment. (E-mail: hennerici@neuro.ma.uni-heidelberg.de)</description><identifier>ISSN: 0301-5629</identifier><identifier>EISSN: 1879-291X</identifier><identifier>DOI: 10.1016/S0301-5629(01)00481-1</identifier><identifier>PMID: 11839413</identifier><identifier>CODEN: USMBA3</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Analysis of Variance ; Animals ; Biological and medical sciences ; Blood Flow Velocity - drug effects ; Blood Flow Velocity - physiology ; Blood-Brain Barrier ; Cerebral revascularization ; Diseases of the nervous system ; Fibrinolytic Agents - therapeutic use ; Male ; Medical sciences ; Neurology ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Rats ; Rats, Sprague-Dawley ; Skull ; Stroke - diagnostic imaging ; Stroke - drug therapy ; Stroke - therapy ; Thrombolysis ; Thrombolytic Therapy - methods ; Tissue Plasminogen Activator - therapeutic use ; Ultrasonic Therapy ; Ultrasonics ; Ultrasonography, Doppler, Transcranial ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Ultrasound in medicine & biology, 2001-12, Vol.27 (12), p.1683-1689</ispartof><rights>2002 World Federation for Ultrasound in Medicine & Biology</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-754a284d69e518c15495bbf5f03f08858475b7d14361d89f25171a040c37749f3</citedby><cites>FETCH-LOGICAL-c509t-754a284d69e518c15495bbf5f03f08858475b7d14361d89f25171a040c37749f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0301562901004811$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13485127$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11839413$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Behrens, Stephan</creatorcontrib><creatorcontrib>Spengos, Konstantinos</creatorcontrib><creatorcontrib>Daffertshofer, Michael</creatorcontrib><creatorcontrib>Schroeck, Helmut</creatorcontrib><creatorcontrib>Dempfle, Carl E</creatorcontrib><creatorcontrib>Hennerici, Michael</creatorcontrib><title>Transcranial ultrasound-improved thrombolysis: diagnostic vs. therapeutic ultrasound</title><title>Ultrasound in medicine & biology</title><addtitle>Ultrasound Med Biol</addtitle><description>Success of stroke treatment with rt-PA depends on rapid vessel recanalization. Enzymatic thrombolysis may be enhanced by additional transcranial application of ultrasound (US). We investigated this novel technique using a 185-kHz probe and compared it to standard diagnostic US.
In vitro studies were performed in a continuous pressure tubing system. Clots were placed in a postmortem skull and treated with rt-PA together with or without transtemporal 185-kHz US insonation (2W/cm
2) and in comparison to 1-MHz diagnostic US (0.5 W/cm
2). Recanalization time was significantly (
p < 0.01) shorter in the 185-kHz (14.1 min) and 1-MHz (17.1 min) US rt-PA treatment group compared to rt-PA treatment alone (29.3 min.). Flow rate was significantly higher (
p < 0.025) and increased faster in the combined treatment group with rt-PA + 185-kHz US compared to rt-PA + 1-MHz US. We investigated the blood-brain barrier in rats after 90-min exposure time of the brain with 185-kHz US, but no damage was observed. Results suggest efficacy and safety of the 185-kHz transducer, which is superior to diagnostic US. Such a novel US probe may be able to optimize thrombolytic stroke treatment. (E-mail: hennerici@neuro.ma.uni-heidelberg.de)</description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Flow Velocity - drug effects</subject><subject>Blood Flow Velocity - physiology</subject><subject>Blood-Brain Barrier</subject><subject>Cerebral revascularization</subject><subject>Diseases of the nervous system</subject><subject>Fibrinolytic Agents - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Skull</subject><subject>Stroke - diagnostic imaging</subject><subject>Stroke - drug therapy</subject><subject>Stroke - therapy</subject><subject>Thrombolysis</subject><subject>Thrombolytic Therapy - methods</subject><subject>Tissue Plasminogen Activator - therapeutic use</subject><subject>Ultrasonic Therapy</subject><subject>Ultrasonics</subject><subject>Ultrasonography, Doppler, Transcranial</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0301-5629</issn><issn>1879-291X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE2LFDEQhoO4uOPqT1Dmouih16pO0kn2IrKou7DgwRG8hXSS1kh_jKnugf33ZnYG57iXFKGet6p4GHuFcImAzYfvwAEr2dTmHeB7AKGxwidshVqZqjb48ylb_UfO2XOiPwCgGq6esXNEzY1AvmKbTXYj-fIk16-Xfs6OpmUMVRq2edrFsJ5_52lop_6eEl2tQ3K_xonm5Nc7uizNmN02Lvv_KfyCnXWup_jyWC_Yjy-fN9c31d23r7fXn-4qL8HMlZLC1VqExkSJ2qMURrZtJzvgHWgttVCyVQEFbzBo09USFToQ4LlSwnT8gr09zC2n_l0izXZI5GPfuzFOC1lVi1oJkAWUB9DniSjHzm5zGly-twh2r9M-6LR7V7bUB50WS-71ccHSDjGcUkd_BXhzBBx513fFo0904rjQEmtVuI8HLhYduxSzJZ_i6GNIOfrZhik9cso_EmSRwg</recordid><startdate>20011201</startdate><enddate>20011201</enddate><creator>Behrens, Stephan</creator><creator>Spengos, Konstantinos</creator><creator>Daffertshofer, Michael</creator><creator>Schroeck, Helmut</creator><creator>Dempfle, Carl E</creator><creator>Hennerici, Michael</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20011201</creationdate><title>Transcranial ultrasound-improved thrombolysis: diagnostic vs. therapeutic ultrasound</title><author>Behrens, Stephan ; Spengos, Konstantinos ; Daffertshofer, Michael ; Schroeck, Helmut ; Dempfle, Carl E ; Hennerici, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-754a284d69e518c15495bbf5f03f08858475b7d14361d89f25171a040c37749f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Flow Velocity - drug effects</topic><topic>Blood Flow Velocity - physiology</topic><topic>Blood-Brain Barrier</topic><topic>Cerebral revascularization</topic><topic>Diseases of the nervous system</topic><topic>Fibrinolytic Agents - therapeutic use</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neurology</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Skull</topic><topic>Stroke - diagnostic imaging</topic><topic>Stroke - drug therapy</topic><topic>Stroke - therapy</topic><topic>Thrombolysis</topic><topic>Thrombolytic Therapy - methods</topic><topic>Tissue Plasminogen Activator - therapeutic use</topic><topic>Ultrasonic Therapy</topic><topic>Ultrasonics</topic><topic>Ultrasonography, Doppler, Transcranial</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Behrens, Stephan</creatorcontrib><creatorcontrib>Spengos, Konstantinos</creatorcontrib><creatorcontrib>Daffertshofer, Michael</creatorcontrib><creatorcontrib>Schroeck, Helmut</creatorcontrib><creatorcontrib>Dempfle, Carl E</creatorcontrib><creatorcontrib>Hennerici, Michael</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Ultrasound in medicine & biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Behrens, Stephan</au><au>Spengos, Konstantinos</au><au>Daffertshofer, Michael</au><au>Schroeck, Helmut</au><au>Dempfle, Carl E</au><au>Hennerici, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transcranial ultrasound-improved thrombolysis: diagnostic vs. therapeutic ultrasound</atitle><jtitle>Ultrasound in medicine & biology</jtitle><addtitle>Ultrasound Med Biol</addtitle><date>2001-12-01</date><risdate>2001</risdate><volume>27</volume><issue>12</issue><spage>1683</spage><epage>1689</epage><pages>1683-1689</pages><issn>0301-5629</issn><eissn>1879-291X</eissn><coden>USMBA3</coden><abstract>Success of stroke treatment with rt-PA depends on rapid vessel recanalization. Enzymatic thrombolysis may be enhanced by additional transcranial application of ultrasound (US). We investigated this novel technique using a 185-kHz probe and compared it to standard diagnostic US.
In vitro studies were performed in a continuous pressure tubing system. Clots were placed in a postmortem skull and treated with rt-PA together with or without transtemporal 185-kHz US insonation (2W/cm
2) and in comparison to 1-MHz diagnostic US (0.5 W/cm
2). Recanalization time was significantly (
p < 0.01) shorter in the 185-kHz (14.1 min) and 1-MHz (17.1 min) US rt-PA treatment group compared to rt-PA treatment alone (29.3 min.). Flow rate was significantly higher (
p < 0.025) and increased faster in the combined treatment group with rt-PA + 185-kHz US compared to rt-PA + 1-MHz US. We investigated the blood-brain barrier in rats after 90-min exposure time of the brain with 185-kHz US, but no damage was observed. Results suggest efficacy and safety of the 185-kHz transducer, which is superior to diagnostic US. Such a novel US probe may be able to optimize thrombolytic stroke treatment. (E-mail: hennerici@neuro.ma.uni-heidelberg.de)</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>11839413</pmid><doi>10.1016/S0301-5629(01)00481-1</doi><tpages>7</tpages></addata></record> |
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| ispartof | Ultrasound in medicine & biology, 2001-12, Vol.27 (12), p.1683-1689 |
| issn | 0301-5629 1879-291X |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Analysis of Variance Animals Biological and medical sciences Blood Flow Velocity - drug effects Blood Flow Velocity - physiology Blood-Brain Barrier Cerebral revascularization Diseases of the nervous system Fibrinolytic Agents - therapeutic use Male Medical sciences Neurology Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Rats Rats, Sprague-Dawley Skull Stroke - diagnostic imaging Stroke - drug therapy Stroke - therapy Thrombolysis Thrombolytic Therapy - methods Tissue Plasminogen Activator - therapeutic use Ultrasonic Therapy Ultrasonics Ultrasonography, Doppler, Transcranial Vascular diseases and vascular malformations of the nervous system |
| title | Transcranial ultrasound-improved thrombolysis: diagnostic vs. therapeutic ultrasound |
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