Gossypol inhibits follicle-stimulating hormone- and epidermal growth factor-stimulated expansion of oocyte-cumulus complexes from porcine preovulatory follicles
The role of gossypol in the cumulus expansion of oocyte-cumulus complexes (OCC) isolated from large antral porcine follicles was investigated. Marked suppression of cumulus expansion stimulated with follicle-stimulating hormone (FSH) and epidermal growth factor (EGF) was observed in the presence of...
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| Veröffentlicht in: | Physiological research 2001, Vol.50 (6), p.627-630 |
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| creator | Kolena, J Vrsanská, S Nagyová, E Jezová, M |
| description | The role of gossypol in the cumulus expansion of oocyte-cumulus complexes (OCC) isolated from large antral porcine follicles was investigated. Marked suppression of cumulus expansion stimulated with follicle-stimulating hormone (FSH) and epidermal growth factor (EGF) was observed in the presence of different concentrations of gossypol. Comparable inhibitory effects were obtained in the presence of NO donor, S-nitroso-N-acetylpenicillamine or sodium nitroprusside, suggesting that the inhibitory effect of gossypol may be mediated via NO generation. The inhibitory effect of gossypol on cumulus expansion of OCC was accompanied by inhibition of progesterone secretion of OCC and the decrease of [125I]EGF binding to granulosa cells. |
| doi_str_mv | 10.33549/physiolres.930181 |
| format | Article |
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Marked suppression of cumulus expansion stimulated with follicle-stimulating hormone (FSH) and epidermal growth factor (EGF) was observed in the presence of different concentrations of gossypol. Comparable inhibitory effects were obtained in the presence of NO donor, S-nitroso-N-acetylpenicillamine or sodium nitroprusside, suggesting that the inhibitory effect of gossypol may be mediated via NO generation. The inhibitory effect of gossypol on cumulus expansion of OCC was accompanied by inhibition of progesterone secretion of OCC and the decrease of [125I]EGF binding to granulosa cells.</description><identifier>ISSN: 0862-8408</identifier><identifier>EISSN: 1802-9973</identifier><identifier>DOI: 10.33549/physiolres.930181</identifier><identifier>PMID: 11829325</identifier><language>eng</language><publisher>Czech Republic</publisher><subject>Animals ; Epidermal Growth Factor - metabolism ; Epidermal Growth Factor - pharmacology ; Female ; Follicle Stimulating Hormone - pharmacology ; Follicular Phase - drug effects ; Gossypol - pharmacology ; In Vitro Techniques ; Iodine Radioisotopes ; Oocytes - cytology ; Oocytes - drug effects ; Oocytes - secretion ; Ovarian Follicle - cytology ; Ovarian Follicle - drug effects ; Ovarian Follicle - secretion ; Progesterone - secretion ; Swine</subject><ispartof>Physiological research, 2001, Vol.50 (6), p.627-630</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,4014,27914,27915,27916</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11829325$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kolena, J</creatorcontrib><creatorcontrib>Vrsanská, S</creatorcontrib><creatorcontrib>Nagyová, E</creatorcontrib><creatorcontrib>Jezová, M</creatorcontrib><title>Gossypol inhibits follicle-stimulating hormone- and epidermal growth factor-stimulated expansion of oocyte-cumulus complexes from porcine preovulatory follicles</title><title>Physiological research</title><addtitle>Physiol Res</addtitle><description>The role of gossypol in the cumulus expansion of oocyte-cumulus complexes (OCC) isolated from large antral porcine follicles was investigated. Marked suppression of cumulus expansion stimulated with follicle-stimulating hormone (FSH) and epidermal growth factor (EGF) was observed in the presence of different concentrations of gossypol. Comparable inhibitory effects were obtained in the presence of NO donor, S-nitroso-N-acetylpenicillamine or sodium nitroprusside, suggesting that the inhibitory effect of gossypol may be mediated via NO generation. The inhibitory effect of gossypol on cumulus expansion of OCC was accompanied by inhibition of progesterone secretion of OCC and the decrease of [125I]EGF binding to granulosa cells.</description><subject>Animals</subject><subject>Epidermal Growth Factor - metabolism</subject><subject>Epidermal Growth Factor - pharmacology</subject><subject>Female</subject><subject>Follicle Stimulating Hormone - pharmacology</subject><subject>Follicular Phase - drug effects</subject><subject>Gossypol - pharmacology</subject><subject>In Vitro Techniques</subject><subject>Iodine Radioisotopes</subject><subject>Oocytes - cytology</subject><subject>Oocytes - drug effects</subject><subject>Oocytes - secretion</subject><subject>Ovarian Follicle - cytology</subject><subject>Ovarian Follicle - drug effects</subject><subject>Ovarian Follicle - secretion</subject><subject>Progesterone - secretion</subject><subject>Swine</subject><issn>0862-8408</issn><issn>1802-9973</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkc1u1TAQhS0Eope2L8ACecUuxT_5sZeoogWpEhtYR76Tca8rJ2PsBJq34VFJuVftahZzzpmj-Rh7L8WV1k1tP6XDWgLFjOXKaiGNfMV20ghVWdvp12wnTKsqUwtzxt6V8iCE6kSn37IzKY2yWjU79veWSlkTRR6mQ9iHuXBPMQaIWJU5jEt0c5ju-YHySBNW3E0DxxQGzKOL_D7Tn_nAvYOZ8rMBN8ljctNWbuLkORGsM1awbNulcKAxRXzE7VSmkSfKECbkKSP9frJTXp9LlAv2xrtY8PI0z9nPmy8_rr9Wd99vv11_vqtA2XqubNOA7-S-9dJp63xrjZYArcKmBgFohNOd7GoJyilXQ2tb0w5OegO1tYPX5-zjMTdl-rVgmfsxFMAY3YS0lL5TtWq1kZtQHYWQt9dl9H3KYXR57aXo_3PpX7j0Ry6b6cMpfdmPOLxYTiD0PwngksY</recordid><startdate>2001</startdate><enddate>2001</enddate><creator>Kolena, J</creator><creator>Vrsanská, S</creator><creator>Nagyová, E</creator><creator>Jezová, M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2001</creationdate><title>Gossypol inhibits follicle-stimulating hormone- and epidermal growth factor-stimulated expansion of oocyte-cumulus complexes from porcine preovulatory follicles</title><author>Kolena, J ; Vrsanská, S ; Nagyová, E ; Jezová, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c294t-955cf71b6f1a39af69831cc62e54c0ce80a371741c2a2a4c69686da1f8c499df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Epidermal Growth Factor - metabolism</topic><topic>Epidermal Growth Factor - pharmacology</topic><topic>Female</topic><topic>Follicle Stimulating Hormone - pharmacology</topic><topic>Follicular Phase - drug effects</topic><topic>Gossypol - pharmacology</topic><topic>In Vitro Techniques</topic><topic>Iodine Radioisotopes</topic><topic>Oocytes - cytology</topic><topic>Oocytes - drug effects</topic><topic>Oocytes - secretion</topic><topic>Ovarian Follicle - cytology</topic><topic>Ovarian Follicle - drug effects</topic><topic>Ovarian Follicle - secretion</topic><topic>Progesterone - secretion</topic><topic>Swine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kolena, J</creatorcontrib><creatorcontrib>Vrsanská, S</creatorcontrib><creatorcontrib>Nagyová, E</creatorcontrib><creatorcontrib>Jezová, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Physiological research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kolena, J</au><au>Vrsanská, S</au><au>Nagyová, E</au><au>Jezová, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gossypol inhibits follicle-stimulating hormone- and epidermal growth factor-stimulated expansion of oocyte-cumulus complexes from porcine preovulatory follicles</atitle><jtitle>Physiological research</jtitle><addtitle>Physiol Res</addtitle><date>2001</date><risdate>2001</risdate><volume>50</volume><issue>6</issue><spage>627</spage><epage>630</epage><pages>627-630</pages><issn>0862-8408</issn><eissn>1802-9973</eissn><abstract>The role of gossypol in the cumulus expansion of oocyte-cumulus complexes (OCC) isolated from large antral porcine follicles was investigated. Marked suppression of cumulus expansion stimulated with follicle-stimulating hormone (FSH) and epidermal growth factor (EGF) was observed in the presence of different concentrations of gossypol. Comparable inhibitory effects were obtained in the presence of NO donor, S-nitroso-N-acetylpenicillamine or sodium nitroprusside, suggesting that the inhibitory effect of gossypol may be mediated via NO generation. The inhibitory effect of gossypol on cumulus expansion of OCC was accompanied by inhibition of progesterone secretion of OCC and the decrease of [125I]EGF binding to granulosa cells.</abstract><cop>Czech Republic</cop><pmid>11829325</pmid><doi>10.33549/physiolres.930181</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Physiological research, 2001, Vol.50 (6), p.627-630 |
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| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB Electronic Journals Library |
| subjects | Animals Epidermal Growth Factor - metabolism Epidermal Growth Factor - pharmacology Female Follicle Stimulating Hormone - pharmacology Follicular Phase - drug effects Gossypol - pharmacology In Vitro Techniques Iodine Radioisotopes Oocytes - cytology Oocytes - drug effects Oocytes - secretion Ovarian Follicle - cytology Ovarian Follicle - drug effects Ovarian Follicle - secretion Progesterone - secretion Swine |
| title | Gossypol inhibits follicle-stimulating hormone- and epidermal growth factor-stimulated expansion of oocyte-cumulus complexes from porcine preovulatory follicles |
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