Population Pharmacokinetics of Aminoglycosides in Critically Ill Trauma Patients on Once-Daily Regimens
BACKGROUNDOnce-daily dosing regimens of aminoglycosides are routinely used in critically ill trauma patients. However, the pharmacokinetic parameters are variable in these patients. The purpose of this study was to evaluate the pharmacokinetics of aminoglycosides in critically ill trauma patients re...
Gespeichert in:
| Veröffentlicht in: | The Journal of Trauma: Injury, Infection, and Critical Care Infection, and Critical Care, 2000-11, Vol.49 (5), p.869-872 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 872 |
|---|---|
| container_issue | 5 |
| container_start_page | 869 |
| container_title | The Journal of Trauma: Injury, Infection, and Critical Care |
| container_volume | 49 |
| creator | Barletta, Jeffrey F. Johnson, Steven B. Nix, David E. Nix, Laura C. Erstad, and Brian L. |
| description | BACKGROUNDOnce-daily dosing regimens of aminoglycosides are routinely used in critically ill trauma patients. However, the pharmacokinetic parameters are variable in these patients. The purpose of this study was to evaluate the pharmacokinetics of aminoglycosides in critically ill trauma patients receiving once-daily dosing regimens.
METHODSAt least two aminoglycoside concentrations were measured in each patient. Population pharmacokinetic parameters were estimated on the basis of a one-compartment structural model and the program nonlinear mixed effects modeling.
RESULTSFifty-three aminoglycoside concentrations from 19 patients were analyzed. The aminoglycoside clearance was 5.47 L/h. The mean volume of distribution was 22.2 L (0.3 L/kg). The mean half-life was 2.9 hours. Serum-aminoglycoside concentrations were undetectable for longer than 12 hours in 4 of 19 patients. Weight, age, or serum creatinine did not significantly explain the variability.
CONCLUSIONThere is marked variability in aminoglycoside pharmacokinetic parameters in critically ill trauma patients. This may lead to prolonged drug-free intervals. Individualized dosing of critically ill trauma patients on the basis of at least two serum-aminoglycoside concentrations seems indicated when using once-daily dosing regimens. |
| doi_str_mv | 10.1097/00005373-200011000-00013 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72424503</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72424503</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3843-31f9d247bdc773db80cc030af7efec7bb8ff1ed228f9a5a292f719b718241f233</originalsourceid><addsrcrecordid>eNp1kV1rHCEUhqW0NEuav1CEQu-m0eNMdS7D9isQyFLSa3Gc467E0a3OEPbf1-1uk6t6oQd83ld4JIRy9omzXl6zujohRQN14LxuzXEQr8iKd9A3SrH-NVkxBtB0oOCCXJXih8pAJ3tQb8lFTanPUqoV2W7Sfglm9inSzc7kydj06CPO3haaHL2ZfEzbcLCp-BEL9ZGus6-3JoQDvQ2BPmSzTIZuagfGuYYivY8Wmy_GV-Inbv2Esbwjb5wJBa_O5yX59e3rw_pHc3f__XZ9c9dYoVrRCO76EVo5jFZKMQ6KWcsEM06iQyuHQTnHcQRQrjedgR6c5P0guYKWOxDiknw89e5z-r1gmfXki8UQTMS0FC2hhbZjR1CdQJtTKRmd3mc_mXzQnOmjZ_3Ps372rP96rtH35zeWYcLxJXi2WoEPZ8CUKsplE60vz5wCKdtjTXuinlKYMZfHsDxh1js0Yd7p__2y-AOSgJVL</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72424503</pqid></control><display><type>article</type><title>Population Pharmacokinetics of Aminoglycosides in Critically Ill Trauma Patients on Once-Daily Regimens</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>Barletta, Jeffrey F. ; Johnson, Steven B. ; Nix, David E. ; Nix, Laura C. ; Erstad, and Brian L.</creator><creatorcontrib>Barletta, Jeffrey F. ; Johnson, Steven B. ; Nix, David E. ; Nix, Laura C. ; Erstad, and Brian L.</creatorcontrib><description>BACKGROUNDOnce-daily dosing regimens of aminoglycosides are routinely used in critically ill trauma patients. However, the pharmacokinetic parameters are variable in these patients. The purpose of this study was to evaluate the pharmacokinetics of aminoglycosides in critically ill trauma patients receiving once-daily dosing regimens.
METHODSAt least two aminoglycoside concentrations were measured in each patient. Population pharmacokinetic parameters were estimated on the basis of a one-compartment structural model and the program nonlinear mixed effects modeling.
RESULTSFifty-three aminoglycoside concentrations from 19 patients were analyzed. The aminoglycoside clearance was 5.47 L/h. The mean volume of distribution was 22.2 L (0.3 L/kg). The mean half-life was 2.9 hours. Serum-aminoglycoside concentrations were undetectable for longer than 12 hours in 4 of 19 patients. Weight, age, or serum creatinine did not significantly explain the variability.
CONCLUSIONThere is marked variability in aminoglycoside pharmacokinetic parameters in critically ill trauma patients. This may lead to prolonged drug-free intervals. Individualized dosing of critically ill trauma patients on the basis of at least two serum-aminoglycoside concentrations seems indicated when using once-daily dosing regimens.</description><identifier>ISSN: 0022-5282</identifier><identifier>EISSN: 1529-8809</identifier><identifier>DOI: 10.1097/00005373-200011000-00013</identifier><identifier>PMID: 11086778</identifier><identifier>CODEN: JOTRA5</identifier><language>eng</language><publisher>Baltimore, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Adolescent ; Adult ; Age Factors ; Aged ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - blood ; Anti-Bacterial Agents - pharmacokinetics ; Biological and medical sciences ; Body Weight ; Creatinine - blood ; Critical Illness ; Drug Administration Schedule ; Drug Monitoring ; Emergency and intensive care: injuries, diseases due to physical agents. Diving. Drowning. Disaster medicine ; General pharmacology ; Gentamicins - administration & dosage ; Gentamicins - blood ; Gentamicins - pharmacokinetics ; Humans ; Intensive care medicine ; Medical sciences ; Metabolic Clearance Rate ; Middle Aged ; Multiple Trauma - drug therapy ; Multiple Trauma - metabolism ; Nonlinear Dynamics ; Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions ; Pharmacology. Drug treatments ; Prospective Studies ; Time Factors ; Tissue Distribution ; Tobramycin - administration & dosage ; Tobramycin - blood ; Tobramycin - pharmacokinetics</subject><ispartof>The Journal of Trauma: Injury, Infection, and Critical Care, 2000-11, Vol.49 (5), p.869-872</ispartof><rights>2000 Lippincott Williams & Wilkins, Inc.</rights><rights>2001 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3843-31f9d247bdc773db80cc030af7efec7bb8ff1ed228f9a5a292f719b718241f233</citedby><cites>FETCH-LOGICAL-c3843-31f9d247bdc773db80cc030af7efec7bb8ff1ed228f9a5a292f719b718241f233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=827743$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11086778$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barletta, Jeffrey F.</creatorcontrib><creatorcontrib>Johnson, Steven B.</creatorcontrib><creatorcontrib>Nix, David E.</creatorcontrib><creatorcontrib>Nix, Laura C.</creatorcontrib><creatorcontrib>Erstad, and Brian L.</creatorcontrib><title>Population Pharmacokinetics of Aminoglycosides in Critically Ill Trauma Patients on Once-Daily Regimens</title><title>The Journal of Trauma: Injury, Infection, and Critical Care</title><addtitle>J Trauma</addtitle><description>BACKGROUNDOnce-daily dosing regimens of aminoglycosides are routinely used in critically ill trauma patients. However, the pharmacokinetic parameters are variable in these patients. The purpose of this study was to evaluate the pharmacokinetics of aminoglycosides in critically ill trauma patients receiving once-daily dosing regimens.
METHODSAt least two aminoglycoside concentrations were measured in each patient. Population pharmacokinetic parameters were estimated on the basis of a one-compartment structural model and the program nonlinear mixed effects modeling.
RESULTSFifty-three aminoglycoside concentrations from 19 patients were analyzed. The aminoglycoside clearance was 5.47 L/h. The mean volume of distribution was 22.2 L (0.3 L/kg). The mean half-life was 2.9 hours. Serum-aminoglycoside concentrations were undetectable for longer than 12 hours in 4 of 19 patients. Weight, age, or serum creatinine did not significantly explain the variability.
CONCLUSIONThere is marked variability in aminoglycoside pharmacokinetic parameters in critically ill trauma patients. This may lead to prolonged drug-free intervals. Individualized dosing of critically ill trauma patients on the basis of at least two serum-aminoglycoside concentrations seems indicated when using once-daily dosing regimens.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - blood</subject><subject>Anti-Bacterial Agents - pharmacokinetics</subject><subject>Biological and medical sciences</subject><subject>Body Weight</subject><subject>Creatinine - blood</subject><subject>Critical Illness</subject><subject>Drug Administration Schedule</subject><subject>Drug Monitoring</subject><subject>Emergency and intensive care: injuries, diseases due to physical agents. Diving. Drowning. Disaster medicine</subject><subject>General pharmacology</subject><subject>Gentamicins - administration & dosage</subject><subject>Gentamicins - blood</subject><subject>Gentamicins - pharmacokinetics</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Medical sciences</subject><subject>Metabolic Clearance Rate</subject><subject>Middle Aged</subject><subject>Multiple Trauma - drug therapy</subject><subject>Multiple Trauma - metabolism</subject><subject>Nonlinear Dynamics</subject><subject>Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions</subject><subject>Pharmacology. Drug treatments</subject><subject>Prospective Studies</subject><subject>Time Factors</subject><subject>Tissue Distribution</subject><subject>Tobramycin - administration & dosage</subject><subject>Tobramycin - blood</subject><subject>Tobramycin - pharmacokinetics</subject><issn>0022-5282</issn><issn>1529-8809</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kV1rHCEUhqW0NEuav1CEQu-m0eNMdS7D9isQyFLSa3Gc467E0a3OEPbf1-1uk6t6oQd83ld4JIRy9omzXl6zujohRQN14LxuzXEQr8iKd9A3SrH-NVkxBtB0oOCCXJXih8pAJ3tQb8lFTanPUqoV2W7Sfglm9inSzc7kydj06CPO3haaHL2ZfEzbcLCp-BEL9ZGus6-3JoQDvQ2BPmSzTIZuagfGuYYivY8Wmy_GV-Inbv2Esbwjb5wJBa_O5yX59e3rw_pHc3f__XZ9c9dYoVrRCO76EVo5jFZKMQ6KWcsEM06iQyuHQTnHcQRQrjedgR6c5P0guYKWOxDiknw89e5z-r1gmfXki8UQTMS0FC2hhbZjR1CdQJtTKRmd3mc_mXzQnOmjZ_3Ps372rP96rtH35zeWYcLxJXi2WoEPZ8CUKsplE60vz5wCKdtjTXuinlKYMZfHsDxh1js0Yd7p__2y-AOSgJVL</recordid><startdate>200011</startdate><enddate>200011</enddate><creator>Barletta, Jeffrey F.</creator><creator>Johnson, Steven B.</creator><creator>Nix, David E.</creator><creator>Nix, Laura C.</creator><creator>Erstad, and Brian L.</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200011</creationdate><title>Population Pharmacokinetics of Aminoglycosides in Critically Ill Trauma Patients on Once-Daily Regimens</title><author>Barletta, Jeffrey F. ; Johnson, Steven B. ; Nix, David E. ; Nix, Laura C. ; Erstad, and Brian L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3843-31f9d247bdc773db80cc030af7efec7bb8ff1ed228f9a5a292f719b718241f233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Anti-Bacterial Agents - blood</topic><topic>Anti-Bacterial Agents - pharmacokinetics</topic><topic>Biological and medical sciences</topic><topic>Body Weight</topic><topic>Creatinine - blood</topic><topic>Critical Illness</topic><topic>Drug Administration Schedule</topic><topic>Drug Monitoring</topic><topic>Emergency and intensive care: injuries, diseases due to physical agents. Diving. Drowning. Disaster medicine</topic><topic>General pharmacology</topic><topic>Gentamicins - administration & dosage</topic><topic>Gentamicins - blood</topic><topic>Gentamicins - pharmacokinetics</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Medical sciences</topic><topic>Metabolic Clearance Rate</topic><topic>Middle Aged</topic><topic>Multiple Trauma - drug therapy</topic><topic>Multiple Trauma - metabolism</topic><topic>Nonlinear Dynamics</topic><topic>Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions</topic><topic>Pharmacology. Drug treatments</topic><topic>Prospective Studies</topic><topic>Time Factors</topic><topic>Tissue Distribution</topic><topic>Tobramycin - administration & dosage</topic><topic>Tobramycin - blood</topic><topic>Tobramycin - pharmacokinetics</topic><toplevel>online_resources</toplevel><creatorcontrib>Barletta, Jeffrey F.</creatorcontrib><creatorcontrib>Johnson, Steven B.</creatorcontrib><creatorcontrib>Nix, David E.</creatorcontrib><creatorcontrib>Nix, Laura C.</creatorcontrib><creatorcontrib>Erstad, and Brian L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of Trauma: Injury, Infection, and Critical Care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barletta, Jeffrey F.</au><au>Johnson, Steven B.</au><au>Nix, David E.</au><au>Nix, Laura C.</au><au>Erstad, and Brian L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Population Pharmacokinetics of Aminoglycosides in Critically Ill Trauma Patients on Once-Daily Regimens</atitle><jtitle>The Journal of Trauma: Injury, Infection, and Critical Care</jtitle><addtitle>J Trauma</addtitle><date>2000-11</date><risdate>2000</risdate><volume>49</volume><issue>5</issue><spage>869</spage><epage>872</epage><pages>869-872</pages><issn>0022-5282</issn><eissn>1529-8809</eissn><coden>JOTRA5</coden><abstract>BACKGROUNDOnce-daily dosing regimens of aminoglycosides are routinely used in critically ill trauma patients. However, the pharmacokinetic parameters are variable in these patients. The purpose of this study was to evaluate the pharmacokinetics of aminoglycosides in critically ill trauma patients receiving once-daily dosing regimens.
METHODSAt least two aminoglycoside concentrations were measured in each patient. Population pharmacokinetic parameters were estimated on the basis of a one-compartment structural model and the program nonlinear mixed effects modeling.
RESULTSFifty-three aminoglycoside concentrations from 19 patients were analyzed. The aminoglycoside clearance was 5.47 L/h. The mean volume of distribution was 22.2 L (0.3 L/kg). The mean half-life was 2.9 hours. Serum-aminoglycoside concentrations were undetectable for longer than 12 hours in 4 of 19 patients. Weight, age, or serum creatinine did not significantly explain the variability.
CONCLUSIONThere is marked variability in aminoglycoside pharmacokinetic parameters in critically ill trauma patients. This may lead to prolonged drug-free intervals. Individualized dosing of critically ill trauma patients on the basis of at least two serum-aminoglycoside concentrations seems indicated when using once-daily dosing regimens.</abstract><cop>Baltimore, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>11086778</pmid><doi>10.1097/00005373-200011000-00013</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-5282 |
| ispartof | The Journal of Trauma: Injury, Infection, and Critical Care, 2000-11, Vol.49 (5), p.869-872 |
| issn | 0022-5282 1529-8809 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72424503 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adolescent Adult Age Factors Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - blood Anti-Bacterial Agents - pharmacokinetics Biological and medical sciences Body Weight Creatinine - blood Critical Illness Drug Administration Schedule Drug Monitoring Emergency and intensive care: injuries, diseases due to physical agents. Diving. Drowning. Disaster medicine General pharmacology Gentamicins - administration & dosage Gentamicins - blood Gentamicins - pharmacokinetics Humans Intensive care medicine Medical sciences Metabolic Clearance Rate Middle Aged Multiple Trauma - drug therapy Multiple Trauma - metabolism Nonlinear Dynamics Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Prospective Studies Time Factors Tissue Distribution Tobramycin - administration & dosage Tobramycin - blood Tobramycin - pharmacokinetics |
| title | Population Pharmacokinetics of Aminoglycosides in Critically Ill Trauma Patients on Once-Daily Regimens |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-14T20%3A55%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Population%20Pharmacokinetics%20of%20Aminoglycosides%20in%20Critically%20Ill%20Trauma%20Patients%20on%20Once-Daily%20Regimens&rft.jtitle=The%20Journal%20of%20Trauma:%20Injury,%20Infection,%20and%20Critical%20Care&rft.au=Barletta,%20Jeffrey%20F.&rft.date=2000-11&rft.volume=49&rft.issue=5&rft.spage=869&rft.epage=872&rft.pages=869-872&rft.issn=0022-5282&rft.eissn=1529-8809&rft.coden=JOTRA5&rft_id=info:doi/10.1097/00005373-200011000-00013&rft_dat=%3Cproquest_cross%3E72424503%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=72424503&rft_id=info:pmid/11086778&rfr_iscdi=true |