Left Medial Temporal Cytosolic Choline in Early Onset Depression
Objective: Previous studies have linked the choline (Cho) resonance seen in proton magnetic resonance spectroscopy (1H-MRS) to major depressive disorder (MDD). We endeavoured to clarify the possible involvement of cytosolic choline in the amygdala (anterior medial temporal region) of juvenile subjec...
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| Veröffentlicht in: | Canadian journal of psychiatry 2001-12, Vol.46 (10), p.959-964 |
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| container_title | Canadian journal of psychiatry |
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| creator | Kusumakar, Vivek MacMaster, Frank P Gates, Larry Sparkes, Sandra J Khan, Shakeela C |
| description | Objective:
Previous studies have linked the choline (Cho) resonance seen in proton magnetic resonance spectroscopy (1H-MRS) to major depressive disorder (MDD). We endeavoured to clarify the possible involvement of cytosolic choline in the amygdala (anterior medial temporal region) of juvenile subjects with MDD.
Method:
A total of 11 age- and sex-matched MDD and control pairs aged 14 to 18 years participated in long-echo proton magnetic resonance spectroscopic imaging (1H-MRSI) of the amygdala. Compounds available include N-acetyl-aspartate (NAA), creatine–phosphocreatine (Cr) and choline-containing compounds.
Results:
Subjects with depression demonstrated lower left amygdala Cho–Cr ratios, compared with control subjects (paired t = 2.624, df 10, P = 0.025). Left amygdala NAA–Cr and right amygdala Cho–Cr and NAA–Cr did not differ significantly between subjects with depression and control subjects. In subjects with depression, simple regression revealed a negative trend between left amygdala Cho–Cr and Beck Depression Inventory (BDI) score (F = 3.509, P = 0.098). Right amygdala NAA–Cr and Cho–Cr did not differ significantly.
Conclusion:
Cytosolic choline appears to be involved in the pathophysiology of early-onset MDD, likely secondary to corticosteroid-neuroendocrine-driven changes. |
| doi_str_mv | 10.1177/070674370104601009 |
| format | Article |
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Previous studies have linked the choline (Cho) resonance seen in proton magnetic resonance spectroscopy (1H-MRS) to major depressive disorder (MDD). We endeavoured to clarify the possible involvement of cytosolic choline in the amygdala (anterior medial temporal region) of juvenile subjects with MDD.
Method:
A total of 11 age- and sex-matched MDD and control pairs aged 14 to 18 years participated in long-echo proton magnetic resonance spectroscopic imaging (1H-MRSI) of the amygdala. Compounds available include N-acetyl-aspartate (NAA), creatine–phosphocreatine (Cr) and choline-containing compounds.
Results:
Subjects with depression demonstrated lower left amygdala Cho–Cr ratios, compared with control subjects (paired t = 2.624, df 10, P = 0.025). Left amygdala NAA–Cr and right amygdala Cho–Cr and NAA–Cr did not differ significantly between subjects with depression and control subjects. In subjects with depression, simple regression revealed a negative trend between left amygdala Cho–Cr and Beck Depression Inventory (BDI) score (F = 3.509, P = 0.098). Right amygdala NAA–Cr and Cho–Cr did not differ significantly.
Conclusion:
Cytosolic choline appears to be involved in the pathophysiology of early-onset MDD, likely secondary to corticosteroid-neuroendocrine-driven changes.</description><identifier>ISSN: 0706-7437</identifier><identifier>EISSN: 1497-0015</identifier><identifier>DOI: 10.1177/070674370104601009</identifier><identifier>PMID: 11816318</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Adolescent ; Amygdala - physiopathology ; Aspartic Acid - analogs & derivatives ; Aspartic Acid - metabolism ; Choline - metabolism ; Creatine - metabolism ; Cytosol - physiology ; Depressive Disorder, Major - diagnosis ; Depressive Disorder, Major - physiopathology ; Dominance, Cerebral - physiology ; Female ; Humans ; Magnetic Resonance Spectroscopy ; Male ; Mental depression ; Personality Inventory ; Reference Values</subject><ispartof>Canadian journal of psychiatry, 2001-12, Vol.46 (10), p.959-964</ispartof><rights>2001 Canadian Psychiatric Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-60bbf22bd7a5e2631122d18f91921c8cf472cbc5e9bc8af1c817ebbb8a1ebf0e3</citedby><cites>FETCH-LOGICAL-c411t-60bbf22bd7a5e2631122d18f91921c8cf472cbc5e9bc8af1c817ebbb8a1ebf0e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/070674370104601009$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/070674370104601009$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,778,782,21802,27907,27908,43604,43605</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11816318$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kusumakar, Vivek</creatorcontrib><creatorcontrib>MacMaster, Frank P</creatorcontrib><creatorcontrib>Gates, Larry</creatorcontrib><creatorcontrib>Sparkes, Sandra J</creatorcontrib><creatorcontrib>Khan, Shakeela C</creatorcontrib><title>Left Medial Temporal Cytosolic Choline in Early Onset Depression</title><title>Canadian journal of psychiatry</title><addtitle>Can J Psychiatry</addtitle><description>Objective:
Previous studies have linked the choline (Cho) resonance seen in proton magnetic resonance spectroscopy (1H-MRS) to major depressive disorder (MDD). We endeavoured to clarify the possible involvement of cytosolic choline in the amygdala (anterior medial temporal region) of juvenile subjects with MDD.
Method:
A total of 11 age- and sex-matched MDD and control pairs aged 14 to 18 years participated in long-echo proton magnetic resonance spectroscopic imaging (1H-MRSI) of the amygdala. Compounds available include N-acetyl-aspartate (NAA), creatine–phosphocreatine (Cr) and choline-containing compounds.
Results:
Subjects with depression demonstrated lower left amygdala Cho–Cr ratios, compared with control subjects (paired t = 2.624, df 10, P = 0.025). Left amygdala NAA–Cr and right amygdala Cho–Cr and NAA–Cr did not differ significantly between subjects with depression and control subjects. In subjects with depression, simple regression revealed a negative trend between left amygdala Cho–Cr and Beck Depression Inventory (BDI) score (F = 3.509, P = 0.098). Right amygdala NAA–Cr and Cho–Cr did not differ significantly.
Conclusion:
Cytosolic choline appears to be involved in the pathophysiology of early-onset MDD, likely secondary to corticosteroid-neuroendocrine-driven changes.</description><subject>Adolescent</subject><subject>Amygdala - physiopathology</subject><subject>Aspartic Acid - analogs & derivatives</subject><subject>Aspartic Acid - metabolism</subject><subject>Choline - metabolism</subject><subject>Creatine - metabolism</subject><subject>Cytosol - physiology</subject><subject>Depressive Disorder, Major - diagnosis</subject><subject>Depressive Disorder, Major - physiopathology</subject><subject>Dominance, Cerebral - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Mental depression</subject><subject>Personality Inventory</subject><subject>Reference Values</subject><issn>0706-7437</issn><issn>1497-0015</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1PwzAMhiMEYmPwBzigSkjcyuKsbZobqIwPaWiXca6S1IFObTOS9rB_T6ZNAoHwwbasx6-tl5BLoLcAnE8ppxlPZpwCTbKQqDgiY0gEjymF9JiMd0C8I0bkzPs1DcFYfkpGADlkM8jH5G6Bpo9esaplE62w3VgXmmLbW2-bWkfFRygdRnUXzaVrttGy89hHD7hx6H1tu3NyYmTj8eJQJ-Ttcb4qnuPF8umluF_EOgHo44wqZRhTFZcpsnAbGKsgNwIEA51rk3CmlU5RKJ1LE0bAUSmVS0BlKM4m5Gavu3H2c0Dfl23tNTaN7NAOvuQsYUzwLIDXv8C1HVwXfitBcJomglERKLantLPeOzTlxtWtdNsSaLlzt_zrbli6OkgPqsXqe-VgZwCme8DLd_xx93_JL0xQgM4</recordid><startdate>20011201</startdate><enddate>20011201</enddate><creator>Kusumakar, Vivek</creator><creator>MacMaster, Frank P</creator><creator>Gates, Larry</creator><creator>Sparkes, Sandra J</creator><creator>Khan, Shakeela C</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>4T-</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20011201</creationdate><title>Left Medial Temporal Cytosolic Choline in Early Onset Depression</title><author>Kusumakar, Vivek ; MacMaster, Frank P ; Gates, Larry ; Sparkes, Sandra J ; Khan, Shakeela C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-60bbf22bd7a5e2631122d18f91921c8cf472cbc5e9bc8af1c817ebbb8a1ebf0e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adolescent</topic><topic>Amygdala - physiopathology</topic><topic>Aspartic Acid - analogs & derivatives</topic><topic>Aspartic Acid - metabolism</topic><topic>Choline - metabolism</topic><topic>Creatine - metabolism</topic><topic>Cytosol - physiology</topic><topic>Depressive Disorder, Major - diagnosis</topic><topic>Depressive Disorder, Major - physiopathology</topic><topic>Dominance, Cerebral - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Mental depression</topic><topic>Personality Inventory</topic><topic>Reference Values</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kusumakar, Vivek</creatorcontrib><creatorcontrib>MacMaster, Frank P</creatorcontrib><creatorcontrib>Gates, Larry</creatorcontrib><creatorcontrib>Sparkes, Sandra J</creatorcontrib><creatorcontrib>Khan, Shakeela C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Docstoc</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Canadian journal of psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kusumakar, Vivek</au><au>MacMaster, Frank P</au><au>Gates, Larry</au><au>Sparkes, Sandra J</au><au>Khan, Shakeela C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Left Medial Temporal Cytosolic Choline in Early Onset Depression</atitle><jtitle>Canadian journal of psychiatry</jtitle><addtitle>Can J Psychiatry</addtitle><date>2001-12-01</date><risdate>2001</risdate><volume>46</volume><issue>10</issue><spage>959</spage><epage>964</epage><pages>959-964</pages><issn>0706-7437</issn><eissn>1497-0015</eissn><abstract>Objective:
Previous studies have linked the choline (Cho) resonance seen in proton magnetic resonance spectroscopy (1H-MRS) to major depressive disorder (MDD). We endeavoured to clarify the possible involvement of cytosolic choline in the amygdala (anterior medial temporal region) of juvenile subjects with MDD.
Method:
A total of 11 age- and sex-matched MDD and control pairs aged 14 to 18 years participated in long-echo proton magnetic resonance spectroscopic imaging (1H-MRSI) of the amygdala. Compounds available include N-acetyl-aspartate (NAA), creatine–phosphocreatine (Cr) and choline-containing compounds.
Results:
Subjects with depression demonstrated lower left amygdala Cho–Cr ratios, compared with control subjects (paired t = 2.624, df 10, P = 0.025). Left amygdala NAA–Cr and right amygdala Cho–Cr and NAA–Cr did not differ significantly between subjects with depression and control subjects. In subjects with depression, simple regression revealed a negative trend between left amygdala Cho–Cr and Beck Depression Inventory (BDI) score (F = 3.509, P = 0.098). Right amygdala NAA–Cr and Cho–Cr did not differ significantly.
Conclusion:
Cytosolic choline appears to be involved in the pathophysiology of early-onset MDD, likely secondary to corticosteroid-neuroendocrine-driven changes.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>11816318</pmid><doi>10.1177/070674370104601009</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; SAGE Complete A-Z List |
| subjects | Adolescent Amygdala - physiopathology Aspartic Acid - analogs & derivatives Aspartic Acid - metabolism Choline - metabolism Creatine - metabolism Cytosol - physiology Depressive Disorder, Major - diagnosis Depressive Disorder, Major - physiopathology Dominance, Cerebral - physiology Female Humans Magnetic Resonance Spectroscopy Male Mental depression Personality Inventory Reference Values |
| title | Left Medial Temporal Cytosolic Choline in Early Onset Depression |
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