Apoptosis of Syncytia Induced by the HIV-1–Envelope Glycoprotein Complex: Influence of Cell Shape and Size

Cells stably transfected with a lymphotropic HIV-1 Env gene form syncytia when cocultured with CD4+CXCR4+ cells. Heterokaryons then spontaneously undergo apoptosis, while manifesting signs of mitochondrial membrane pemeabilization as well as nuclear chromatin condensation. Modulation of cellular geo...

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Veröffentlicht in:	Exp Cell Res 2000-11, Vol.261 (1), p.119-126
Hauptverfasser:	Ferri, Karine F, Jacotot, Etienne, Leduc, Philip, Geuskens, Maurice, Ingber, Donald E, Kroemer, Guido
Format:	Artikel
Sprache:	eng
Schlagworte:	AIF Apoptosis - physiology Biochemistry, Molecular Biology CD4 Antigens - physiology Cell Adhesion cell death cell geometry Cell Nucleus - ultrastructure Cell Size - physiology Culture Techniques - methods cytochrome c Gene Products, env - genetics Gene Products, env - physiology Giant Cells - cytology Giant Cells - physiology Giant Cells - virology HeLa Cells HIV-1 - physiology Humans Life Sciences mitochondria Mitochondria - ultrastructure Recombinant Proteins - metabolism Transfection
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