Context Dependence of Different Modules for Posttranscriptional Enhancement of Gene Expression from Retroviral Vectors

We present a systematic comparison of three modules that enhance expression from retroviral gene transfer vectors at a posttranscriptional level: (i) splice signals (SS) that create an intron in the 5’ untranslated region; (ii) constitutive RNA transport elements (CTE), originally discovered in D-ty...

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Veröffentlicht in:	Molecular therapy 2000-11, Vol.2 (5), p.435-445
Hauptverfasser:	Schambach, Axel, Wodrich, Harald, Hildinger, Markus, Bohne, Jens, Kräusslich, Hans-Georg, Baum, Christopher
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus ATP-Binding Cassette, Sub-Family B, Member 1 - genetics ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Cell Nucleus - metabolism CTE DNA, Complementary - metabolism Gene Expression Gene therapy gene transfer Genetic Vectors Globins - genetics Globins - metabolism Green Fluorescent Proteins Hepatitis Hepatitis B Virus, Woodchuck - genetics HIV HIV Core Protein p24 - genetics HIV Core Protein p24 - metabolism HIV Protease - genetics HIV Protease - metabolism Human immunodeficiency virus Humans Immune system Indicators and Reagents - metabolism Introns Kinases Luminescent Proteins - genetics Luminescent Proteins - metabolism Molecular biology Proteins Regulatory Sequences, Nucleic Acid retroviral vector Retroviridae - genetics RNA - metabolism RNA Processing, Post-Transcriptional splice signals Transgenes Vectors (Biology) Viruses WPRE
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