Relationship between mutations in the DNA gyrase and topoisomerase IV genes and nadifloxacin resistance in clinically isolated quinolone-resistant Staphylococcus aureus

We analyzed the relationship between resistance to nadifloxacin, a fluoroquinolone antimicrobial agent, and mutations in the quinolone resistance-determining regions (QRDRs) of the A subunit of DNA gyrase and topoisomerase IV, in 24 clinical isolates of Staphylococcus aureus. Seven known mutations w...

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Veröffentlicht in:	Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2001-09, Vol.7 (3), p.191-194
Hauptverfasser:	OIZUMI, Nobuyuki, KAWABATA, Shigekatsu, HIRAO, Maasa, WATANABE, Kozo, OKUNO, Shiro, FUJIWARA, Tsutomu, KIKUCHI, Mikio
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Infective Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Bacterial Proteins - genetics Biological and medical sciences DNA Gyrase - genetics DNA Topoisomerase IV - genetics Drug Resistance, Bacterial - genetics Fluoroquinolones Gene Expression Medical sciences Microbial Sensitivity Tests Multidrug Resistance-Associated Proteins Mutation Pharmacology. Drug treatments Quinolizines - pharmacology Quinolones - pharmacology Staphylococcus aureus - drug effects Staphylococcus aureus - enzymology Staphylococcus aureus - genetics
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