The IL-6 family cytokines, interleukin-6, interleukin-11, oncostatin M, and leukemia inhibitory factor, enhance mast cell growth through fibroblast-dependent pathway in mice

Mast cell hyperplasia is observed in various inflammatory skin diseases. Although the mechanisms involved in the pathogenesis of these conditions remains largely uninvestigated, it is speculated that mediators produced in the lesional skin provide a favorable microenvironment for mast cell growth. A...

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Veröffentlicht in:	Archives of Dermatological Research 2001-11, Vol.293 (10), p.508-514
Hauptverfasser:	GYOTOKU, Eiichi, MORITA, Eishin, KAMEYOSHI, Yoshikazu, HIRAGUN, Takaaki, YAMAMOTO, Shoso, HIDE, Michihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Antigens, CD - metabolism Biological and medical sciences Bone marrow Bone Marrow Cells - cytology Bone Marrow Cells - metabolism c-Kit protein Cell Division - drug effects Cell growth Cell proliferation Cells, Cultured Coculture Techniques Cytokine Receptor gp130 Cytokines Dermatology Fibroblasts Fibroblasts - physiology Glycoprotein gp130 Growth Inhibitors - pharmacology Hyperplasia Interleukin 11 Interleukin 6 Interleukin-11 - pharmacology Interleukin-6 - pharmacology Leukemia Leukemia Inhibitory Factor Lymphokines - pharmacology Male Mast cells Mast Cells - cytology Mast Cells - metabolism Medical sciences Membrane Glycoproteins - metabolism Mice Mice, Inbred Strains Oncostatin M Peptides - pharmacology Phosphorylation Polymerase chain reaction Receptors, Cytokine - metabolism RNA-directed DNA polymerase Skin diseases Skin involvement in other diseases. Miscellaneous. General aspects Stem cell factor Stem Cell Factor - metabolism Stem cells Tyrosine
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