Rationale and Perspective of Endothelin-1 Antagonism in Acute Heart Failure

A role of the potent and long-acting vasoconstrictor peptide endothelin (ET)-1 in the pathophysiology of chronic human heart failure has been postulated, based upon indirect evidence such as elevated plasma ET-1 levels and their relationship to the degree of haemodynamic impairment. Acute heart fail...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 2001-11, Vol.38 Suppl 2, p.S53-S57
Hauptverfasser:	Kiowski, Wolfgang, Suetsch, Gabor, Oechslin, Erwin, Schalcher, Christoph, Brunner-LaRocca, Hans P, Bertel, Osmund
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animals Antihypertensive Agents - therapeutic use Bosentan Dogs Endothelin Receptor Antagonists Endothelin-1 - antagonists & inhibitors Endothelin-1 - blood Heart Failure - drug therapy Heart Failure - physiopathology Humans Peptides, Cyclic - therapeutic use Receptor, Endothelin A Receptor, Endothelin B Sulfonamides - therapeutic use
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