Aseptic Loosening of a Knee Prosthesis as Imaged on FDG Positron Emission Tomography
FDG positron emission tomography (PET) has been presented as a highly accurate technique (n = 51; accuracy 96%, no false-positive results) for diagnosing chronic osteomyelitis. The authors report a case of high FDG uptake in aseptic loosening of a knee prosthesis. The FDG uptake mechanism in infecti...
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| Veröffentlicht in: | Clinical nuclear medicine 2000-11, Vol.25 (11), p.923-923 |
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| container_title | Clinical nuclear medicine |
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| creator | DE WINTER, FREDERIC VAN DE WIELE, CHRISTOPHE DE CLERCQ, DIRK VOGELAERS, DIRK DE BONDT, PIETER DIERCKX, RUDI ANDRE |
| description | FDG positron emission tomography (PET) has been presented as a highly accurate technique (n = 51; accuracy 96%, no false-positive results) for diagnosing chronic osteomyelitis. The authors report a case of high FDG uptake in aseptic loosening of a knee prosthesis. The FDG uptake mechanism in infection is related to increased tracer accumulation in activated macrophages, leukocytes, and fibroblasts. Macrophages and fibroblasts also play a role in aseptic loosening. This may be reflected in an elevated FDG uptake. Although promising, FDG PET probably will not be able to distinguish infection from inflammation. Further investigation is needed to determine its value in loosened prostheses. |
| doi_str_mv | 10.1097/00003072-200011000-00017 |
| format | Article |
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The authors report a case of high FDG uptake in aseptic loosening of a knee prosthesis. The FDG uptake mechanism in infection is related to increased tracer accumulation in activated macrophages, leukocytes, and fibroblasts. Macrophages and fibroblasts also play a role in aseptic loosening. This may be reflected in an elevated FDG uptake. Although promising, FDG PET probably will not be able to distinguish infection from inflammation. Further investigation is needed to determine its value in loosened prostheses.</description><identifier>ISSN: 0363-9762</identifier><identifier>EISSN: 1536-0229</identifier><identifier>DOI: 10.1097/00003072-200011000-00017</identifier><identifier>PMID: 11079596</identifier><identifier>CODEN: CNMEDK</identifier><language>eng</language><publisher>Philadelphia, PA: Lippincott Williams & Wilkins, Inc</publisher><subject>Biological and medical sciences ; Fluorodeoxyglucose F18 ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Knee - diagnostic imaging ; Knee Prosthesis ; Medical sciences ; Osteoarticular system. 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The authors report a case of high FDG uptake in aseptic loosening of a knee prosthesis. The FDG uptake mechanism in infection is related to increased tracer accumulation in activated macrophages, leukocytes, and fibroblasts. Macrophages and fibroblasts also play a role in aseptic loosening. This may be reflected in an elevated FDG uptake. Although promising, FDG PET probably will not be able to distinguish infection from inflammation. Further investigation is needed to determine its value in loosened prostheses.</description><subject>Biological and medical sciences</subject><subject>Fluorodeoxyglucose F18</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Knee - diagnostic imaging</subject><subject>Knee Prosthesis</subject><subject>Medical sciences</subject><subject>Osteoarticular system. Muscles</subject><subject>Prosthesis Failure</subject><subject>Radionuclide investigations</subject><subject>Radiopharmaceuticals</subject><subject>Tomography, Emission-Computed</subject><issn>0363-9762</issn><issn>1536-0229</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtP6zAQhS10EZTHX0CWkO4u4EdiO0sE5SEqwaKsLTuZtLk3iYsnFeLf49ICK7ywz0jfGXuOCaGcXXBW6kuWlmRaZCIJztOWbYTeIxNeSJUxIco_ZMKkklmplTgkR4j_EqG4yg_IYbLosijVhMyvEFZjW9FZCAhDOyxoaKijjwMAfY4BxyVgi9QhfejdAmoaBnp7c0efA7ZjTMW0bxHbJOahD4voVsv3E7LfuA7hdHcek5fb6fz6Pps93T1cX82ySppcZ8B8YXyel7yRXHupoVGFNrISvgKoZeGZKVleKy-4YErUtTLCO2eUz8EUUh6Tv9u-qxhe14CjTW-poOvcAGGNVoucC8U3oNmCVZoIIzR2FdvexXfLmd0kar8Std-J2s9Ek_Vsd8fa91D_GHcRJuB8BzisXNdEN1QtfnNG6FKwROVb6i10I0T8363fINoluG5c2t_-U34Ak22LkA</recordid><startdate>200011</startdate><enddate>200011</enddate><creator>DE WINTER, FREDERIC</creator><creator>VAN DE WIELE, CHRISTOPHE</creator><creator>DE CLERCQ, DIRK</creator><creator>VOGELAERS, DIRK</creator><creator>DE BONDT, PIETER</creator><creator>DIERCKX, RUDI ANDRE</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200011</creationdate><title>Aseptic Loosening of a Knee Prosthesis as Imaged on FDG Positron Emission Tomography</title><author>DE WINTER, FREDERIC ; VAN DE WIELE, CHRISTOPHE ; DE CLERCQ, DIRK ; VOGELAERS, DIRK ; DE BONDT, PIETER ; DIERCKX, RUDI ANDRE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3847-e0b58b4491f317b37ef65783c2bceed35b08904d6b212062dd682baa86b4e8533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Biological and medical sciences</topic><topic>Fluorodeoxyglucose F18</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Knee - diagnostic imaging</topic><topic>Knee Prosthesis</topic><topic>Medical sciences</topic><topic>Osteoarticular system. Muscles</topic><topic>Prosthesis Failure</topic><topic>Radionuclide investigations</topic><topic>Radiopharmaceuticals</topic><topic>Tomography, Emission-Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DE WINTER, FREDERIC</creatorcontrib><creatorcontrib>VAN DE WIELE, CHRISTOPHE</creatorcontrib><creatorcontrib>DE CLERCQ, DIRK</creatorcontrib><creatorcontrib>VOGELAERS, DIRK</creatorcontrib><creatorcontrib>DE BONDT, PIETER</creatorcontrib><creatorcontrib>DIERCKX, RUDI ANDRE</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical nuclear medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DE WINTER, FREDERIC</au><au>VAN DE WIELE, CHRISTOPHE</au><au>DE CLERCQ, DIRK</au><au>VOGELAERS, DIRK</au><au>DE BONDT, PIETER</au><au>DIERCKX, RUDI ANDRE</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aseptic Loosening of a Knee Prosthesis as Imaged on FDG Positron Emission Tomography</atitle><jtitle>Clinical nuclear medicine</jtitle><addtitle>Clin Nucl Med</addtitle><date>2000-11</date><risdate>2000</risdate><volume>25</volume><issue>11</issue><spage>923</spage><epage>923</epage><pages>923-923</pages><issn>0363-9762</issn><eissn>1536-0229</eissn><coden>CNMEDK</coden><abstract>FDG positron emission tomography (PET) has been presented as a highly accurate technique (n = 51; accuracy 96%, no false-positive results) for diagnosing chronic osteomyelitis. The authors report a case of high FDG uptake in aseptic loosening of a knee prosthesis. The FDG uptake mechanism in infection is related to increased tracer accumulation in activated macrophages, leukocytes, and fibroblasts. Macrophages and fibroblasts also play a role in aseptic loosening. This may be reflected in an elevated FDG uptake. Although promising, FDG PET probably will not be able to distinguish infection from inflammation. Further investigation is needed to determine its value in loosened prostheses.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>11079596</pmid><doi>10.1097/00003072-200011000-00017</doi><tpages>1</tpages></addata></record> |
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| ispartof | Clinical nuclear medicine, 2000-11, Vol.25 (11), p.923-923 |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Biological and medical sciences Fluorodeoxyglucose F18 Humans Investigative techniques, diagnostic techniques (general aspects) Knee - diagnostic imaging Knee Prosthesis Medical sciences Osteoarticular system. Muscles Prosthesis Failure Radionuclide investigations Radiopharmaceuticals Tomography, Emission-Computed |
| title | Aseptic Loosening of a Knee Prosthesis as Imaged on FDG Positron Emission Tomography |
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