Nicotine-Induced Contraction in the Rat Coronary Artery: Possible Involvement of the Endothelium, Reactive Oxygen Species and COX-1 Metabolites

Nicotine caused a contraction of the rat coronary artery in the presence of N-nitro-L-arginine methyl ester (L-NAME) and arachidonic acid, and did not in the absence of these agents. The present experiments were undertaken to pharmacologically characterize the nicotine-induced contraction in ring pr...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 2001-10, Vol.38 Suppl 1, p.S21-S25
Hauptverfasser:	Kurahashi, Kazuyoshi, Shirahase, Hiroaki, Nakamura, Shohei, Tarumi, Tadaaki, Koshino, Yasuaki, Wang, Ai-Min, Nishihashi, Tsuyoshi, Shimizu, Yoshiharu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Coronary Vessels - drug effects Coronary Vessels - physiology Cyclooxygenase 1 Cyclooxygenase Inhibitors - pharmacology Dose-Response Relationship, Drug Endothelium, Vascular - drug effects Endothelium, Vascular - physiology Enzyme Inhibitors - pharmacology In Vitro Techniques Isoenzymes - antagonists & inhibitors Isoenzymes - metabolism Isoenzymes - physiology Male Membrane Proteins Muscle Contraction - drug effects Muscle Contraction - physiology Nicotine - pharmacology Nicotinic Agonists - pharmacology Prostaglandin-Endoperoxide Synthases - metabolism Prostaglandin-Endoperoxide Synthases - physiology Rats Rats, Wistar Reactive Oxygen Species - metabolism Thromboxane A2 - antagonists & inhibitors Thromboxane-A Synthase - antagonists & inhibitors
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