Diurnal changes in glucocorticoid sensitivity in human peripheral blood samples

The secretion of cortisol, a principle homeostatic regulator in humans, shows a circadian rhythm, with high concentrations in the morning and low levels in the evening and at night. Tissue response to hormones is dependent on hormone concentrations but also on a variety of cellular factors, such as...

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Veröffentlicht in:	Steroids 2000-12, Vol.65 (12), p.851-856
Hauptverfasser:	Gratsias, Yiannis, Moutsatsou, Paraskevi, Chrysanthopoulou, Georgia, Tsagarakis, Stellios, Thalassinos, Nikolaos, Sekeris, Constantine E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenals. Interrenals Adrenocortical hormones. Regulation Adult Biological and medical sciences Blood Cells - drug effects Blood Cells - physiology Circadian Rhythm Cortisol Dexamethasone - pharmacology Diurnal rhythm Dose-Response Relationship, Drug Female Fundamental and applied biological sciences. Psychology Gender Glucocorticoid receptor Glucocorticoids - blood Glucocorticoids - pharmacology Glucocorticoids - physiology Human Humans Hydrocortisone - blood Hydrocortisone - pharmacology Hydrocortisone - physiology Hypothalamo-Hypophyseal System Lipopolysaccharides - pharmacology Lymphocytes Male Normal Distribution Pituitary-Adrenal System Sensitivity Sex Factors Statistics, Nonparametric TNF-α Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - drug effects Tumor Necrosis Factor-alpha - metabolism Vertebrates: endocrinology
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