Influence of Endothelin-1(1-31) on Smooth Muscle Tone and Cholinergic Nerve-Mediated Contraction in Rat Isolated Trachea

Endothelin-1(1-21) (ET-1(1-21)) is a strong candidate as a significant mediator in asthma, in part because of its powerful spasmogenic actions and its ability to enhance cholinergic nerve-mediated contraction in human and animal airway smooth muscle. In the study reported here, we have demonstrated...

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