Formation of 9,10-Unsaturation in the Mitomycins: Facile Fragmentation of β-Alkyl-β-aryl-α-oxo-γ-butyrolactones

A facile fragmentation of β-alkyl-β-aryl-α-oxo-γ-butyrolactones is reported. A study to assist in the elucidation of the mechanism of the reaction is also revealed.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Organic letters 2000-11, Vol.2 (23), p.3619-3621
Hauptverfasser:	Ziegler, Frederick E, Berlin, Michael Y, Lee, Kyungae, Looker, Adam R
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antineoplastic - chemical synthesis Antibiotics, Antineoplastic - chemistry Butyrates - chemistry Indicators and Reagents Lactones - chemistry Mitomycins - chemical synthesis Mitomycins - chemistry Stereoisomerism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A facile fragmentation of β-alkyl-β-aryl-α-oxo-γ-butyrolactones is reported. A study to assist in the elucidation of the mechanism of the reaction is also revealed.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol000245g