Bradykinin B1 receptor is constitutively expressed in the rat sensory nervous system
Using immunocytochemistry with an antibody raised to a specific rat bradykinin B1 receptor sequence, we showed that the B1 receptor was expressed in the naive rat sensory nervous system. B1 immunoreactivity was seen in laminae 1 and 2 of the dorsal horn of the spinal cord, where primary afferents te...
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| Veröffentlicht in: | Neuroscience letters 2000-11, Vol.294 (3), p.175-178 |
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| container_title | Neuroscience letters |
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| creator | Wotherspoon, Glen Winter, Janet |
| description | Using immunocytochemistry with an antibody raised to a specific rat bradykinin B1 receptor sequence, we showed that the B1 receptor was expressed in the naive rat sensory nervous system. B1 immunoreactivity was seen in laminae 1 and 2 of the dorsal horn of the spinal cord, where primary afferents terminate, and on peripheral nerve terminals in the bladder. B1 receptor was co-expressed preferentially with IB4 positive, but not calcitonin gene-related peptide (CGRP) containing C-cell bodies in the dorsal root ganglion. B1 activation has an important role in the hyperalgesia associated with inflammation, but the site of action of B1 antagonists has generally been believed to be on peripheral, non-neuronal cells. The striking distribution of B1 receptors on sensory neurones suggests that a direct action of B1 activators on the nervous system may also contribute to hyperalgesia. |
| doi_str_mv | 10.1016/S0304-3940(00)01561-5 |
| format | Article |
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The striking distribution of B1 receptors on sensory neurones suggests that a direct action of B1 activators on the nervous system may also contribute to hyperalgesia.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/S0304-3940(00)01561-5</identifier><identifier>PMID: 11072143</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; B1 bradykinin receptor ; Biological and medical sciences ; Calcitonin Gene-Related Peptide - metabolism ; Central nervous system ; Central neurotransmission. Neuromudulation. Pathways and receptors ; Dorsal root ganglia ; Fundamental and applied biological sciences. Psychology ; Ganglia, Spinal - metabolism ; Immunocytochemistry ; Male ; Nerve terminals ; Neurons, Afferent - metabolism ; Presynaptic Terminals - metabolism ; Rats ; Rats, Wistar ; Receptor, Bradykinin B1 ; Receptors, Bradykinin - metabolism ; Spinal Cord - metabolism ; Spinal cord dorsal horn ; Urinary Bladder - metabolism ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience letters, 2000-11, Vol.294 (3), p.175-178</ispartof><rights>2000 Elsevier Science Ireland Ltd</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c480t-846792f06a5fa525829090a0ebdeed2098e4c29b54784c18187c1a6647809d3a3</citedby><cites>FETCH-LOGICAL-c480t-846792f06a5fa525829090a0ebdeed2098e4c29b54784c18187c1a6647809d3a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304394000015615$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=817316$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11072143$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wotherspoon, Glen</creatorcontrib><creatorcontrib>Winter, Janet</creatorcontrib><title>Bradykinin B1 receptor is constitutively expressed in the rat sensory nervous system</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>Using immunocytochemistry with an antibody raised to a specific rat bradykinin B1 receptor sequence, we showed that the B1 receptor was expressed in the naive rat sensory nervous system. B1 immunoreactivity was seen in laminae 1 and 2 of the dorsal horn of the spinal cord, where primary afferents terminate, and on peripheral nerve terminals in the bladder. B1 receptor was co-expressed preferentially with IB4 positive, but not calcitonin gene-related peptide (CGRP) containing C-cell bodies in the dorsal root ganglion. B1 activation has an important role in the hyperalgesia associated with inflammation, but the site of action of B1 antagonists has generally been believed to be on peripheral, non-neuronal cells. The striking distribution of B1 receptors on sensory neurones suggests that a direct action of B1 activators on the nervous system may also contribute to hyperalgesia.</description><subject>Animals</subject><subject>B1 bradykinin receptor</subject><subject>Biological and medical sciences</subject><subject>Calcitonin Gene-Related Peptide - metabolism</subject><subject>Central nervous system</subject><subject>Central neurotransmission. Neuromudulation. Pathways and receptors</subject><subject>Dorsal root ganglia</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Ganglia, Spinal - metabolism</subject><subject>Immunocytochemistry</subject><subject>Male</subject><subject>Nerve terminals</subject><subject>Neurons, Afferent - metabolism</subject><subject>Presynaptic Terminals - metabolism</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptor, Bradykinin B1</subject><subject>Receptors, Bradykinin - metabolism</subject><subject>Spinal Cord - metabolism</subject><subject>Spinal cord dorsal horn</subject><subject>Urinary Bladder - metabolism</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtr3DAQgEVJSTaPn9AiCIT04GQkS5Z9Kt2QpoFAD03OQiuPqVqvvdVol_jfR5td0mNgYBj45vUx9knAlQBRXf-CElRRNgouAb6A0JUo9Ac2E7WRhWmMPGCzN-SIHRP9AQAttDpkR0KAkUKVM_Y4j66d_oYhDHwueESPqzRGHoj7caAU0jqFDfYTx-dVRCJseUbTb-TRJU440BgnPmDcjGviNFHC5Sn72Lme8GyfT9jT99vHmx_Fw8-7-5tvD4VXNaSiVpVpZAeV053TUteygQYc4KJFbCU0NSovm4VWplZe1Pk1L1xV5RKatnTlCbvYzV3F8d8aKdllII997wbM11gjFZgSZAb1DvRxJIrY2VUMSxcnK8BuddpXnXbrykKOrU6rc9_n_YL1Yont_669vwyc7wFH3vVddIMP9MbVwpSiytTXHYVZxiZgtOQDDh7bkIUn247hnUNeAKPvkLA</recordid><startdate>20001124</startdate><enddate>20001124</enddate><creator>Wotherspoon, Glen</creator><creator>Winter, Janet</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20001124</creationdate><title>Bradykinin B1 receptor is constitutively expressed in the rat sensory nervous system</title><author>Wotherspoon, Glen ; Winter, Janet</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c480t-846792f06a5fa525829090a0ebdeed2098e4c29b54784c18187c1a6647809d3a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>B1 bradykinin receptor</topic><topic>Biological and medical sciences</topic><topic>Calcitonin Gene-Related Peptide - metabolism</topic><topic>Central nervous system</topic><topic>Central neurotransmission. Neuromudulation. Pathways and receptors</topic><topic>Dorsal root ganglia</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Ganglia, Spinal - metabolism</topic><topic>Immunocytochemistry</topic><topic>Male</topic><topic>Nerve terminals</topic><topic>Neurons, Afferent - metabolism</topic><topic>Presynaptic Terminals - metabolism</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptor, Bradykinin B1</topic><topic>Receptors, Bradykinin - metabolism</topic><topic>Spinal Cord - metabolism</topic><topic>Spinal cord dorsal horn</topic><topic>Urinary Bladder - metabolism</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wotherspoon, Glen</creatorcontrib><creatorcontrib>Winter, Janet</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wotherspoon, Glen</au><au>Winter, Janet</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bradykinin B1 receptor is constitutively expressed in the rat sensory nervous system</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2000-11-24</date><risdate>2000</risdate><volume>294</volume><issue>3</issue><spage>175</spage><epage>178</epage><pages>175-178</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>Using immunocytochemistry with an antibody raised to a specific rat bradykinin B1 receptor sequence, we showed that the B1 receptor was expressed in the naive rat sensory nervous system. B1 immunoreactivity was seen in laminae 1 and 2 of the dorsal horn of the spinal cord, where primary afferents terminate, and on peripheral nerve terminals in the bladder. B1 receptor was co-expressed preferentially with IB4 positive, but not calcitonin gene-related peptide (CGRP) containing C-cell bodies in the dorsal root ganglion. B1 activation has an important role in the hyperalgesia associated with inflammation, but the site of action of B1 antagonists has generally been believed to be on peripheral, non-neuronal cells. The striking distribution of B1 receptors on sensory neurones suggests that a direct action of B1 activators on the nervous system may also contribute to hyperalgesia.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>11072143</pmid><doi>10.1016/S0304-3940(00)01561-5</doi><tpages>4</tpages></addata></record> |
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| ispartof | Neuroscience letters, 2000-11, Vol.294 (3), p.175-178 |
| issn | 0304-3940 1872-7972 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals B1 bradykinin receptor Biological and medical sciences Calcitonin Gene-Related Peptide - metabolism Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Dorsal root ganglia Fundamental and applied biological sciences. Psychology Ganglia, Spinal - metabolism Immunocytochemistry Male Nerve terminals Neurons, Afferent - metabolism Presynaptic Terminals - metabolism Rats Rats, Wistar Receptor, Bradykinin B1 Receptors, Bradykinin - metabolism Spinal Cord - metabolism Spinal cord dorsal horn Urinary Bladder - metabolism Vertebrates: nervous system and sense organs |
| title | Bradykinin B1 receptor is constitutively expressed in the rat sensory nervous system |
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