Association study of schizophrenia spectrum disorders and dopamine D3 receptor gene: is schizoaffective disorder special?
Alterations in dopamine neurotransmission have been hypothesized to play a role in the etiology of schizophrenia. We considered the dopamine D3 receptor gene on chromosome 3 as a candidate gene for an association analysis. We compared PCR-based genotype markers for healthy controls ( n=120) and pati...
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| Veröffentlicht in: | Psychiatry research 2000-10, Vol.96 (2), p.179-183 |
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| container_title | Psychiatry research |
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| creator | Meszaros, Kurt Lenzinger, Elisabeth Hornik, Kurt Füreder, Thomas Stompe, Thomas Willinger, Ulrike Heiden, Angela Fathi, Nahid Gerhard, Elisabeth Fuchs, Karoline Sieghart, Werner Kasper, Siegfried Aschauer, Harald N |
| description | Alterations in dopamine neurotransmission have been hypothesized to play a role in the etiology of schizophrenia. We considered the dopamine D3 receptor gene on chromosome 3 as a candidate gene for an association analysis. We compared PCR-based genotype markers for healthy controls (
n=120) and patients (
n=95) with schizophrenia and schizophrenia spectrum disorders as diagnosed by consensus according to DSM-III-R. Our results possibly indicate an association of schizoaffective disorder with DRD3 homozygosity (
P=0.056). |
| doi_str_mv | 10.1016/S0165-1781(00)00209-2 |
| format | Article |
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n=120) and patients (
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n=120) and patients (
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| subjects | Adult Adult and adolescent clinical studies Association Biological and medical sciences Chromosomes, Human, Pair 3 D3 receptor gene Female Homozygote Humans Male Medical sciences Polymerase Chain Reaction Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Psychotic Disorders - diagnosis Psychotic Disorders - genetics Receptors, Dopamine D2 - genetics Receptors, Dopamine D3 Schizoaffective disorder Schizophrenia Schizophrenia - diagnosis Schizophrenia - genetics |
| title | Association study of schizophrenia spectrum disorders and dopamine D3 receptor gene: is schizoaffective disorder special? |
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