Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues

In search of vascular smooth muscle cell differentiation markers, we identified two genes encoding members of a new family of type II integral membrane proteins. Both are ubiquitously expressed, and tissue-specific alternative mRNA initiation and splicing generate at least two major isoforms of each...

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Veröffentlicht in:	Journal of cell science 2001-12, Vol.114 (Pt 24), p.4485-4498
Hauptverfasser:	Zhang, Q, Skepper, J N, Yang, F, Davies, J D, Hegyi, L, Roberts, R G, Weissberg, P L, Ellis, J A, Shanahan, C M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Biomarkers Cell Differentiation - genetics Cells, Cultured COS Cells Cytoskeletal Proteins DNA, Complementary - isolation & purification Humans Immune Sera - chemistry In Situ Hybridization, Fluorescence Membrane Proteins - chemistry Membrane Proteins - genetics Membrane Proteins - immunology Membrane Proteins - metabolism Mice Microfilament Proteins Molecular Sequence Data Multigene Family Muscle Proteins - chemistry Muscle Proteins - genetics Muscle Proteins - metabolism Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - metabolism Nerve Tissue Proteins Nuclear Envelope - metabolism Nuclear Localization Signals - genetics Nuclear Proteins - chemistry Nuclear Proteins - genetics Nuclear Proteins - immunology Nuclear Proteins - metabolism Organ Specificity - genetics Protein Structure, Tertiary - genetics Rats Repetitive Sequences, Amino Acid Sequence Homology, Amino Acid Spectrin - metabolism Subcellular Fractions - metabolism
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