Advances in Bioartificial Liver Assist Devices
: Rapid advances in development of bioartificial liver assist devices (BLADs) are exciting clinical interest in the application of BLAD technology for support of patients with acute liver failure. Four devices (Circe Biomedical HepatAssist®, Vitagen ELAD™, Gerlach BELS, and Excorp Medical BLSS) that...
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| Veröffentlicht in: | Annals of the New York Academy of Sciences 2001-11, Vol.944 (1), p.320-333 |
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| container_title | Annals of the New York Academy of Sciences |
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| creator | PATZER II, JOHN F. |
| description | : Rapid advances in development of bioartificial liver assist devices (BLADs) are exciting clinical interest in the application of BLAD technology for support of patients with acute liver failure. Four devices (Circe Biomedical HepatAssist®, Vitagen ELAD™, Gerlach BELS, and Excorp Medical BLSS) that rely on hepatocytes cultured in hollow‐fiber membrane technology are currently in various stages of clinical evaluation. Several alternative approaches for culture and perfusion of hepatocytes have been evaluated in preclinical, large animal models of liver failure, or at a laboratory scale. Engineering design issues with respect to xenotransplantation, BLAD perfusion, hepatocyte functionality and culture maintenance, and ultimate distribution of a BLAD to a clinical site are delineated. |
| doi_str_mv | 10.1111/j.1749-6632.2001.tb03844.x |
| format | Article |
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Four devices (Circe Biomedical HepatAssist®, Vitagen ELAD™, Gerlach BELS, and Excorp Medical BLSS) that rely on hepatocytes cultured in hollow‐fiber membrane technology are currently in various stages of clinical evaluation. Several alternative approaches for culture and perfusion of hepatocytes have been evaluated in preclinical, large animal models of liver failure, or at a laboratory scale. 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Engineering design issues with respect to xenotransplantation, BLAD perfusion, hepatocyte functionality and culture maintenance, and ultimate distribution of a BLAD to a clinical site are delineated.</description><subject>acute liver failure</subject><subject>Animals</subject><subject>bioartificial liver assist device</subject><subject>Bioartificial Organs</subject><subject>Disease Models, Animal</subject><subject>hepatocyte</subject><subject>Hepatocytes</subject><subject>Humans</subject><subject>Liver Failure, Acute - therapy</subject><subject>Liver, Artificial</subject><subject>Perfusion</subject><subject>Transplantation, Heterologous</subject><issn>0077-8923</issn><issn>1749-6632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkMlOwzAQQC0EoqXwCyjiwC3BW-KYCyoFCqgqQiyFk2UnE8klXYjT0v49rlKVM77MwW_eSA-hM4Ij4t_FOCKCyzBJGI0oxiSqDWYp59FqD7V3X_uojbEQYSopa6Ej58YepSkXh6hFiJAiSUkbRd18qacZuMBOg2s701VtC5tZXQYDu4Qq6DpnXR3cwNJ66hgdFLp0cLKdHfR2d_vauw8HT_2HXncQZhxLHBYURAFZXsg01zimYDTT1MRUaOCS-UGMERwnGWUs5iTn3CSQGSEhNYYkrIPOG--8mn0vwNVqYl0GZamnMFs4JSjHMcPMg5cNmFUz5yoo1LyyE12tFcFqU0uN1SaJ2iRRm1pqW0ut_PLp9srCTCD_W93m8cBVA_zYEtb_UKvhZ_eFUewNYWPwEWG1M-jqSyWCiViNhn2VvvdHffnxrB7ZL0ITiNk</recordid><startdate>200111</startdate><enddate>200111</enddate><creator>PATZER II, JOHN F.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200111</creationdate><title>Advances in Bioartificial Liver Assist Devices</title><author>PATZER II, JOHN F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4090-f2e7fecdf98da052eba3a2b527ae49327a1bb7406c233541d44b6ecb79e8bb163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>acute liver failure</topic><topic>Animals</topic><topic>bioartificial liver assist device</topic><topic>Bioartificial Organs</topic><topic>Disease Models, Animal</topic><topic>hepatocyte</topic><topic>Hepatocytes</topic><topic>Humans</topic><topic>Liver Failure, Acute - therapy</topic><topic>Liver, Artificial</topic><topic>Perfusion</topic><topic>Transplantation, Heterologous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PATZER II, JOHN F.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of the New York Academy of Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PATZER II, JOHN F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Advances in Bioartificial Liver Assist Devices</atitle><jtitle>Annals of the New York Academy of Sciences</jtitle><addtitle>Ann N Y Acad Sci</addtitle><date>2001-11</date><risdate>2001</risdate><volume>944</volume><issue>1</issue><spage>320</spage><epage>333</epage><pages>320-333</pages><issn>0077-8923</issn><eissn>1749-6632</eissn><abstract>: Rapid advances in development of bioartificial liver assist devices (BLADs) are exciting clinical interest in the application of BLAD technology for support of patients with acute liver failure. 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| ispartof | Annals of the New York Academy of Sciences, 2001-11, Vol.944 (1), p.320-333 |
| issn | 0077-8923 1749-6632 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | acute liver failure Animals bioartificial liver assist device Bioartificial Organs Disease Models, Animal hepatocyte Hepatocytes Humans Liver Failure, Acute - therapy Liver, Artificial Perfusion Transplantation, Heterologous |
| title | Advances in Bioartificial Liver Assist Devices |
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