Predicting Influenza Infections during Epidemics with Use of a Clinical Case Definition
Combined pharyngeal and nasal swab specimens were collected from 100 subjects who presented with a flu-like illness (fever>37.8°C plus 2 of 4 symptoms: cough, myalgia, sore throat, and headache) of
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| Veröffentlicht in: | Clinical infectious diseases 2000-11, Vol.31 (5), p.1166-1169 |
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| container_title | Clinical infectious diseases |
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| creator | Boivin, Guy Hardy, Isabelle Tellier, Guy Maziade, Jean |
| description | Combined pharyngeal and nasal swab specimens were collected from 100 subjects who presented with a flu-like illness (fever>37.8°C plus 2 of 4 symptoms: cough, myalgia, sore throat, and headache) of |
| doi_str_mv | 10.1086/317425 |
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The rate of laboratory-confirmed influenza infection was 72% according to cell culture findings and 79% according to the results of multiplex reverse-transcription polymerase chain reaction (RT-PCR) analysis (85%, influenza AH3; 15%, influenza B). All subjects for whom these results were discordant (negative culture and positive PCR) presented with a temperature ⩾38.2°C as well as 3 or 4 of the symptoms in the clinical case definition. Stepwise logistic regression showed that cough (odds ratio [OR], 6.7; 95% confidence interval [CI], 1.4–34.1; P = .02) and fever (OR, 3.1; 95% CI, 1.4–8.0; P = .01) were the only factors significantly associated with a positive PCR test for influenza. The positive predictive value, negative predictive value, sensitivity, and the specificity of a case definition including fever (temperature of >38°C) and cough for the diagnosis of influenza infection during this flu season were 86.8%, 39.3%, 77.6%, and 55.0%, respectively.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1086/317425</identifier><identifier>PMID: 11073747</identifier><identifier>CODEN: CIDIEL</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adult ; Aged ; Animals ; Biological and medical sciences ; Canada, Quebec ; Cell Line ; Cough ; Disease Outbreaks ; Diseases ; Female ; Fever ; Headache ; Human mycoses ; Humans ; Infections ; Infectious diseases ; Influenza A virus ; Influenza virus ; Influenza, Human - diagnosis ; Influenza, Human - epidemiology ; Influenza, Human - virology ; Major Articles ; Male ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Muscular Diseases ; Mycoses ; Mycoses of the respiratory system ; Orthomyxoviridae ; Orthomyxoviridae - genetics ; Orthomyxoviridae - isolation & purification ; Pain ; Pharyngitis ; Polymerase chain reaction ; Predictive Value of Tests ; Quebec - epidemiology ; RNA, Viral - analysis ; RNA, Viral - genetics ; Specimens ; Symptoms ; Viruses</subject><ispartof>Clinical infectious diseases, 2000-11, Vol.31 (5), p.1166-1169</ispartof><rights>Copyright 2000 The Infectious Diseases Society of America</rights><rights>2000 by the Infectious Diseases Society of America 2000</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-e2285ad542d9efd44be3b83e877de184d65d3f9ec798d90554e47f6e236e6c843</citedby><cites>FETCH-LOGICAL-c419t-e2285ad542d9efd44be3b83e877de184d65d3f9ec798d90554e47f6e236e6c843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/4461404$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/4461404$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,777,781,800,27905,27906,57998,58231</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=842787$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11073747$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boivin, Guy</creatorcontrib><creatorcontrib>Hardy, Isabelle</creatorcontrib><creatorcontrib>Tellier, Guy</creatorcontrib><creatorcontrib>Maziade, Jean</creatorcontrib><title>Predicting Influenza Infections during Epidemics with Use of a Clinical Case Definition</title><title>Clinical infectious diseases</title><addtitle>Clinical Infectious Diseases</addtitle><addtitle>Clinical Infectious Diseases</addtitle><description>Combined pharyngeal and nasal swab specimens were collected from 100 subjects who presented with a flu-like illness (fever>37.8°C plus 2 of 4 symptoms: cough, myalgia, sore throat, and headache) of <72 hours' duration at 3 different clinics in the province of Quebec, Canada, during the 1998–1999 flu season. The rate of laboratory-confirmed influenza infection was 72% according to cell culture findings and 79% according to the results of multiplex reverse-transcription polymerase chain reaction (RT-PCR) analysis (85%, influenza AH3; 15%, influenza B). All subjects for whom these results were discordant (negative culture and positive PCR) presented with a temperature ⩾38.2°C as well as 3 or 4 of the symptoms in the clinical case definition. Stepwise logistic regression showed that cough (odds ratio [OR], 6.7; 95% confidence interval [CI], 1.4–34.1; P = .02) and fever (OR, 3.1; 95% CI, 1.4–8.0; P = .01) were the only factors significantly associated with a positive PCR test for influenza. The positive predictive value, negative predictive value, sensitivity, and the specificity of a case definition including fever (temperature of >38°C) and cough for the diagnosis of influenza infection during this flu season were 86.8%, 39.3%, 77.6%, and 55.0%, respectively.</description><subject>Adult</subject><subject>Aged</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Canada, Quebec</subject><subject>Cell Line</subject><subject>Cough</subject><subject>Disease Outbreaks</subject><subject>Diseases</subject><subject>Female</subject><subject>Fever</subject><subject>Headache</subject><subject>Human mycoses</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Influenza A virus</subject><subject>Influenza virus</subject><subject>Influenza, Human - diagnosis</subject><subject>Influenza, Human - epidemiology</subject><subject>Influenza, Human - virology</subject><subject>Major Articles</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Muscular Diseases</subject><subject>Mycoses</subject><subject>Mycoses of the respiratory system</subject><subject>Orthomyxoviridae</subject><subject>Orthomyxoviridae - genetics</subject><subject>Orthomyxoviridae - isolation & purification</subject><subject>Pain</subject><subject>Pharyngitis</subject><subject>Polymerase chain reaction</subject><subject>Predictive Value of Tests</subject><subject>Quebec - epidemiology</subject><subject>RNA, Viral - analysis</subject><subject>RNA, Viral - genetics</subject><subject>Specimens</subject><subject>Symptoms</subject><subject>Viruses</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1P3DAQhi1UVCgtvwChIKTeQu34M0fYZWElEEgtAnGxvPYYTLPJYifqx68nUVbLqerJ43kfz1gPQvsEnxCsxDdKJCv4FtolnMpc8JJ86GvMVc4UVTvoU0ovGBOiMP-IdgjBkkomd9H9bQQXbBvqp2xe-6qD-q8ZKuh7TZ0y18UhO18FB8tgU_YrtM_ZXYKs8ZnJJlWogzVVNjF9awq-vw4PP6Ntb6oEX9bnHrqbnf-YXOZXNxfzyelVbhkp2xyKQnHjOCtcCd4xtgC6UBSUlA6IYk5wR30JVpbKlZhzBkx6AQUVIKxidA99HeeuYvPaQWr1MiQLVWVqaLqkZcEwJ1L8FyRSlYoL9Q7a2KQUwetVDEsT_2iC9eBaj6578HA9sVsswb1ja7k9cLwGTOoV-WhqG9KGU6yQaqCORqrpVv9edTAyL6lt4oZiTBCGBwn5GIfUwu9NbOJPLfqvcH358Kin12dUzm7v9Xf6Bs1NpxU</recordid><startdate>20001101</startdate><enddate>20001101</enddate><creator>Boivin, Guy</creator><creator>Hardy, Isabelle</creator><creator>Tellier, Guy</creator><creator>Maziade, Jean</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20001101</creationdate><title>Predicting Influenza Infections during Epidemics with Use of a Clinical Case Definition</title><author>Boivin, Guy ; Hardy, Isabelle ; Tellier, Guy ; Maziade, Jean</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-e2285ad542d9efd44be3b83e877de184d65d3f9ec798d90554e47f6e236e6c843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Canada, Quebec</topic><topic>Cell Line</topic><topic>Cough</topic><topic>Disease Outbreaks</topic><topic>Diseases</topic><topic>Female</topic><topic>Fever</topic><topic>Headache</topic><topic>Human mycoses</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Influenza A virus</topic><topic>Influenza virus</topic><topic>Influenza, Human - diagnosis</topic><topic>Influenza, Human - epidemiology</topic><topic>Influenza, Human - virology</topic><topic>Major Articles</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Muscular Diseases</topic><topic>Mycoses</topic><topic>Mycoses of the respiratory system</topic><topic>Orthomyxoviridae</topic><topic>Orthomyxoviridae - genetics</topic><topic>Orthomyxoviridae - isolation & purification</topic><topic>Pain</topic><topic>Pharyngitis</topic><topic>Polymerase chain reaction</topic><topic>Predictive Value of Tests</topic><topic>Quebec - epidemiology</topic><topic>RNA, Viral - analysis</topic><topic>RNA, Viral - genetics</topic><topic>Specimens</topic><topic>Symptoms</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boivin, Guy</creatorcontrib><creatorcontrib>Hardy, Isabelle</creatorcontrib><creatorcontrib>Tellier, Guy</creatorcontrib><creatorcontrib>Maziade, Jean</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boivin, Guy</au><au>Hardy, Isabelle</au><au>Tellier, Guy</au><au>Maziade, Jean</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predicting Influenza Infections during Epidemics with Use of a Clinical Case Definition</atitle><jtitle>Clinical infectious diseases</jtitle><stitle>Clinical Infectious Diseases</stitle><addtitle>Clinical Infectious Diseases</addtitle><date>2000-11-01</date><risdate>2000</risdate><volume>31</volume><issue>5</issue><spage>1166</spage><epage>1169</epage><pages>1166-1169</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><coden>CIDIEL</coden><abstract>Combined pharyngeal and nasal swab specimens were collected from 100 subjects who presented with a flu-like illness (fever>37.8°C plus 2 of 4 symptoms: cough, myalgia, sore throat, and headache) of <72 hours' duration at 3 different clinics in the province of Quebec, Canada, during the 1998–1999 flu season. The rate of laboratory-confirmed influenza infection was 72% according to cell culture findings and 79% according to the results of multiplex reverse-transcription polymerase chain reaction (RT-PCR) analysis (85%, influenza AH3; 15%, influenza B). All subjects for whom these results were discordant (negative culture and positive PCR) presented with a temperature ⩾38.2°C as well as 3 or 4 of the symptoms in the clinical case definition. Stepwise logistic regression showed that cough (odds ratio [OR], 6.7; 95% confidence interval [CI], 1.4–34.1; P = .02) and fever (OR, 3.1; 95% CI, 1.4–8.0; P = .01) were the only factors significantly associated with a positive PCR test for influenza. The positive predictive value, negative predictive value, sensitivity, and the specificity of a case definition including fever (temperature of >38°C) and cough for the diagnosis of influenza infection during this flu season were 86.8%, 39.3%, 77.6%, and 55.0%, respectively.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>11073747</pmid><doi>10.1086/317425</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Adult Aged Animals Biological and medical sciences Canada, Quebec Cell Line Cough Disease Outbreaks Diseases Female Fever Headache Human mycoses Humans Infections Infectious diseases Influenza A virus Influenza virus Influenza, Human - diagnosis Influenza, Human - epidemiology Influenza, Human - virology Major Articles Male Medical sciences Middle Aged Multivariate Analysis Muscular Diseases Mycoses Mycoses of the respiratory system Orthomyxoviridae Orthomyxoviridae - genetics Orthomyxoviridae - isolation & purification Pain Pharyngitis Polymerase chain reaction Predictive Value of Tests Quebec - epidemiology RNA, Viral - analysis RNA, Viral - genetics Specimens Symptoms Viruses |
| title | Predicting Influenza Infections during Epidemics with Use of a Clinical Case Definition |
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