Visual hallucinations are associated with lower αbungarotoxin binding in dementia with Lewy bodies
Patients with dementia with Lewy bodies (DLB) commonly experience psychotic symptoms, most notably visual hallucinations. Previously, it has been shown that visual hallucinations in DLB are associated with reduced cortical choline acetyltransferase activity, a marker of cholinergic innervation, but...
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| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 2001-12, Vol.70 (4), p.571-579 |
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| creator | Court, J.A Ballard, C.G Piggott, M.A Johnson, M O'Brien, J.T Holmes, C Cairns, N Lantos, P Perry, R.H Jaros, E Perry, E.K |
| description | Patients with dementia with Lewy bodies (DLB) commonly experience psychotic symptoms, most notably visual hallucinations. Previously, it has been shown that visual hallucinations in DLB are associated with reduced cortical choline acetyltransferase activity, a marker of cholinergic innervation, but not with predominantly postsynaptic muscarinic M1 receptor binding. In the present investigation, nicotinic acetylcholine receptor (nAChR) levels in the temporal cortex (Brodmann's areas [BA] 20 and 36) were measured in a group of 24 prospectively assessed DLB patients; comparisons were made between groups with or without visual and auditory hallucinations and delusional misidentification. Visual hallucinations and delusional misidentification were associated with lower [
125I]αbungarotoxin binding in areas 36 and 20 (
P |
| doi_str_mv | 10.1016/S0091-3057(01)00644-X |
| format | Article |
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125I]αbungarotoxin binding in areas 36 and 20 (
P<.05), but not with changes in [
3H]epibatidine binding. There were no significant associations with auditory hallucinations. [
3H]epibatidine, but not [
125I]αbungarotoxin, binding for all DLB cases was reduced compared to controls (
P<.001). Loss of cortical α7 nicotinic receptors may contribute to hallucinations and delusional misidentification in DLB, with implications for treatment and understanding the mechanisms of psychotic symptoms in dementia.</description><identifier>ISSN: 0091-3057</identifier><identifier>EISSN: 1873-5177</identifier><identifier>DOI: 10.1016/S0091-3057(01)00644-X</identifier><identifier>PMID: 11796155</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>a-Bungarotoxin ; Aged ; Aged, 80 and over ; alpha7 Nicotinic Acetylcholine Receptor ; Binding Sites ; Bungarotoxins - metabolism ; Delusional misidentification ; Dementia with Lewy bodies ; Female ; Hallucinations - metabolism ; Humans ; Lewy Body Disease - metabolism ; Male ; Nicotinic acetylcholine receptors ; Prospective Studies ; Receptors, Nicotinic - metabolism ; Regression Analysis ; Temporal cortex ; Temporal Lobe - metabolism ; Visual hallucinations ; α7 subunits</subject><ispartof>Pharmacology, biochemistry and behavior, 2001-12, Vol.70 (4), p.571-579</ispartof><rights>2001 Elsevier Science Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c446t-ca0ac08d15689e34536a04918b3ec84c9dd51f4bc2eed7e3089d92d0cbb8417b3</citedby><cites>FETCH-LOGICAL-c446t-ca0ac08d15689e34536a04918b3ec84c9dd51f4bc2eed7e3089d92d0cbb8417b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0091-3057(01)00644-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11796155$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Court, J.A</creatorcontrib><creatorcontrib>Ballard, C.G</creatorcontrib><creatorcontrib>Piggott, M.A</creatorcontrib><creatorcontrib>Johnson, M</creatorcontrib><creatorcontrib>O'Brien, J.T</creatorcontrib><creatorcontrib>Holmes, C</creatorcontrib><creatorcontrib>Cairns, N</creatorcontrib><creatorcontrib>Lantos, P</creatorcontrib><creatorcontrib>Perry, R.H</creatorcontrib><creatorcontrib>Jaros, E</creatorcontrib><creatorcontrib>Perry, E.K</creatorcontrib><title>Visual hallucinations are associated with lower αbungarotoxin binding in dementia with Lewy bodies</title><title>Pharmacology, biochemistry and behavior</title><addtitle>Pharmacol Biochem Behav</addtitle><description>Patients with dementia with Lewy bodies (DLB) commonly experience psychotic symptoms, most notably visual hallucinations. Previously, it has been shown that visual hallucinations in DLB are associated with reduced cortical choline acetyltransferase activity, a marker of cholinergic innervation, but not with predominantly postsynaptic muscarinic M1 receptor binding. In the present investigation, nicotinic acetylcholine receptor (nAChR) levels in the temporal cortex (Brodmann's areas [BA] 20 and 36) were measured in a group of 24 prospectively assessed DLB patients; comparisons were made between groups with or without visual and auditory hallucinations and delusional misidentification. Visual hallucinations and delusional misidentification were associated with lower [
125I]αbungarotoxin binding in areas 36 and 20 (
P<.05), but not with changes in [
3H]epibatidine binding. There were no significant associations with auditory hallucinations. [
3H]epibatidine, but not [
125I]αbungarotoxin, binding for all DLB cases was reduced compared to controls (
P<.001). Loss of cortical α7 nicotinic receptors may contribute to hallucinations and delusional misidentification in DLB, with implications for treatment and understanding the mechanisms of psychotic symptoms in dementia.</description><subject>a-Bungarotoxin</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>alpha7 Nicotinic Acetylcholine Receptor</subject><subject>Binding Sites</subject><subject>Bungarotoxins - metabolism</subject><subject>Delusional misidentification</subject><subject>Dementia with Lewy bodies</subject><subject>Female</subject><subject>Hallucinations - metabolism</subject><subject>Humans</subject><subject>Lewy Body Disease - metabolism</subject><subject>Male</subject><subject>Nicotinic acetylcholine receptors</subject><subject>Prospective Studies</subject><subject>Receptors, Nicotinic - metabolism</subject><subject>Regression Analysis</subject><subject>Temporal cortex</subject><subject>Temporal Lobe - metabolism</subject><subject>Visual hallucinations</subject><subject>α7 subunits</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1uFDEQhC0EIpvAI4B8QuQw0D1jjz0nFEX8SStx4Ee5Wf7pTYxm7WDPsOSxeBGeiUl2Bcecug9fVUlVjD1DeIWA_evPAAM2HUj1EvAUoBeiuXjAVqhV10hU6iFb_UOO2HGt3wFAtL16zI4Q1dCjlCvmv8U625Ff2XGcfUx2ijlVbgtxW2v20U4U-C5OV3zMOyr8z283p0tb8pR_xcRdTCGmS768gbaUpmj39Jp2N9zlEKk-YY82dqz09HBP2Nd3b7-cf2jWn95_PD9bN16Ifmq8BetBB5S9HqgTsustiAG168hr4YcQJG6E8y1RUNSBHsLQBvDOaYHKdSfsxd73uuQfM9XJbGP1NI42UZ6rUa0AiVLcC6JupehRL6Dcg77kWgttzHWJW1tuDIK5ncHczWBuOzaA5m4Gc7Honh8CZrel8F916H0B3uwBWvr4GamY6iMlTyEW8pMJOd4T8RdR-5nm</recordid><startdate>20011201</startdate><enddate>20011201</enddate><creator>Court, J.A</creator><creator>Ballard, C.G</creator><creator>Piggott, M.A</creator><creator>Johnson, M</creator><creator>O'Brien, J.T</creator><creator>Holmes, C</creator><creator>Cairns, N</creator><creator>Lantos, P</creator><creator>Perry, R.H</creator><creator>Jaros, E</creator><creator>Perry, E.K</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20011201</creationdate><title>Visual hallucinations are associated with lower αbungarotoxin binding in dementia with Lewy bodies</title><author>Court, J.A ; Ballard, C.G ; Piggott, M.A ; Johnson, M ; O'Brien, J.T ; Holmes, C ; Cairns, N ; Lantos, P ; Perry, R.H ; Jaros, E ; Perry, E.K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c446t-ca0ac08d15689e34536a04918b3ec84c9dd51f4bc2eed7e3089d92d0cbb8417b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>a-Bungarotoxin</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>alpha7 Nicotinic Acetylcholine Receptor</topic><topic>Binding Sites</topic><topic>Bungarotoxins - metabolism</topic><topic>Delusional misidentification</topic><topic>Dementia with Lewy bodies</topic><topic>Female</topic><topic>Hallucinations - metabolism</topic><topic>Humans</topic><topic>Lewy Body Disease - metabolism</topic><topic>Male</topic><topic>Nicotinic acetylcholine receptors</topic><topic>Prospective Studies</topic><topic>Receptors, Nicotinic - metabolism</topic><topic>Regression Analysis</topic><topic>Temporal cortex</topic><topic>Temporal Lobe - metabolism</topic><topic>Visual hallucinations</topic><topic>α7 subunits</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Court, J.A</creatorcontrib><creatorcontrib>Ballard, C.G</creatorcontrib><creatorcontrib>Piggott, M.A</creatorcontrib><creatorcontrib>Johnson, M</creatorcontrib><creatorcontrib>O'Brien, J.T</creatorcontrib><creatorcontrib>Holmes, C</creatorcontrib><creatorcontrib>Cairns, N</creatorcontrib><creatorcontrib>Lantos, P</creatorcontrib><creatorcontrib>Perry, R.H</creatorcontrib><creatorcontrib>Jaros, E</creatorcontrib><creatorcontrib>Perry, E.K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Court, J.A</au><au>Ballard, C.G</au><au>Piggott, M.A</au><au>Johnson, M</au><au>O'Brien, J.T</au><au>Holmes, C</au><au>Cairns, N</au><au>Lantos, P</au><au>Perry, R.H</au><au>Jaros, E</au><au>Perry, E.K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Visual hallucinations are associated with lower αbungarotoxin binding in dementia with Lewy bodies</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>2001-12-01</date><risdate>2001</risdate><volume>70</volume><issue>4</issue><spage>571</spage><epage>579</epage><pages>571-579</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><abstract>Patients with dementia with Lewy bodies (DLB) commonly experience psychotic symptoms, most notably visual hallucinations. Previously, it has been shown that visual hallucinations in DLB are associated with reduced cortical choline acetyltransferase activity, a marker of cholinergic innervation, but not with predominantly postsynaptic muscarinic M1 receptor binding. In the present investigation, nicotinic acetylcholine receptor (nAChR) levels in the temporal cortex (Brodmann's areas [BA] 20 and 36) were measured in a group of 24 prospectively assessed DLB patients; comparisons were made between groups with or without visual and auditory hallucinations and delusional misidentification. Visual hallucinations and delusional misidentification were associated with lower [
125I]αbungarotoxin binding in areas 36 and 20 (
P<.05), but not with changes in [
3H]epibatidine binding. There were no significant associations with auditory hallucinations. [
3H]epibatidine, but not [
125I]αbungarotoxin, binding for all DLB cases was reduced compared to controls (
P<.001). Loss of cortical α7 nicotinic receptors may contribute to hallucinations and delusional misidentification in DLB, with implications for treatment and understanding the mechanisms of psychotic symptoms in dementia.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>11796155</pmid><doi>10.1016/S0091-3057(01)00644-X</doi><tpages>9</tpages></addata></record> |
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| subjects | a-Bungarotoxin Aged Aged, 80 and over alpha7 Nicotinic Acetylcholine Receptor Binding Sites Bungarotoxins - metabolism Delusional misidentification Dementia with Lewy bodies Female Hallucinations - metabolism Humans Lewy Body Disease - metabolism Male Nicotinic acetylcholine receptors Prospective Studies Receptors, Nicotinic - metabolism Regression Analysis Temporal cortex Temporal Lobe - metabolism Visual hallucinations α7 subunits |
| title | Visual hallucinations are associated with lower αbungarotoxin binding in dementia with Lewy bodies |
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