Visual hallucinations are associated with lower αbungarotoxin binding in dementia with Lewy bodies

Patients with dementia with Lewy bodies (DLB) commonly experience psychotic symptoms, most notably visual hallucinations. Previously, it has been shown that visual hallucinations in DLB are associated with reduced cortical choline acetyltransferase activity, a marker of cholinergic innervation, but...

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Veröffentlicht in:Pharmacology, biochemistry and behavior biochemistry and behavior, 2001-12, Vol.70 (4), p.571-579
Hauptverfasser: Court, J.A, Ballard, C.G, Piggott, M.A, Johnson, M, O'Brien, J.T, Holmes, C, Cairns, N, Lantos, P, Perry, R.H, Jaros, E, Perry, E.K
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Sprache:eng
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Zusammenfassung:Patients with dementia with Lewy bodies (DLB) commonly experience psychotic symptoms, most notably visual hallucinations. Previously, it has been shown that visual hallucinations in DLB are associated with reduced cortical choline acetyltransferase activity, a marker of cholinergic innervation, but not with predominantly postsynaptic muscarinic M1 receptor binding. In the present investigation, nicotinic acetylcholine receptor (nAChR) levels in the temporal cortex (Brodmann's areas [BA] 20 and 36) were measured in a group of 24 prospectively assessed DLB patients; comparisons were made between groups with or without visual and auditory hallucinations and delusional misidentification. Visual hallucinations and delusional misidentification were associated with lower [ 125I]αbungarotoxin binding in areas 36 and 20 ( P
ISSN:0091-3057
1873-5177
DOI:10.1016/S0091-3057(01)00644-X