Attenuation of Expression of γ-Glutamylcysteine Synthetase by Ribozyme Transfection Enhance Insulin Secretion by Pancreatic β Cell Line, MIN6

Low levels of intracellular antioxidant enzyme activities as well as glutathione (GSH) concentrations have been described in pancreatic β cells. We examined the effects of intracellular GSH depletion on insulin secretion and the role of intracellular GSH in signal transduction in β cell line, MIN6 c...

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Veröffentlicht in:	Biochemical and biophysical research communications 2000-11, Vol.278 (1), p.236-240
Hauptverfasser:	Kondo, Hideaki, Mori, Satoko, Takino, Hirofumi, Kijima, Hiroshi, Yamasaki, Hironori, Ozaki, Masako, Tetsuya, Iida, Urata, Yoshishige, Abe, Takahiro, Sera, Yasunori, Yamakawa, Kenji, Kawasaki, Eiji, Yamaguchi, Yoshihiko, Kondo, Takahito, Eguchi, Katsumi
Format:	Artikel
Sprache:	eng
Schlagworte:	[Ca2+]i Adenosine Triphosphate - metabolism Aniline Compounds - pharmacology Animals antioxidant enzymes Blotting, Northern Calcium - metabolism Cell Line Dose-Response Relationship, Drug Enzyme-Linked Immunosorbent Assay Fluorescent Dyes - pharmacology g-glutamylcysteine synthase Glucose - pharmacology Glutamate-Cysteine Ligase - metabolism glutathione Glutathione - metabolism Insulin - metabolism Insulin Secretion Islets of Langerhans - cytology Islets of Langerhans - enzymology Mice Microscopy, Fluorescence Plasmids - metabolism redox RNA, Catalytic - metabolism RNA, Messenger - metabolism Transfection Xanthenes - pharmacology
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