A Nuclease Hypersensitive Element in the Human c-myc Promoter Adopts Several Distinct i-Tetraplex Structures

Nucleic acid structure-function correlations are pivotal to major biological events like transcription, replication, and recombination. Depending on intracellular conditions in vivo and buffer composition in vitro, DNA appears capable of inexhaustible structure variation. At moderately acidic, or ev...

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Veröffentlicht in:	Biochemical and biophysical research communications 2000-11, Vol.278 (1), p.158-166
Hauptverfasser:	Simonsson, Tomas, Pribylova, Marketa, Vorlickova, Michaela
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles c-myc gene Circular Dichroism Deoxyribonucleases - metabolism DNA DNA - chemistry DNA - metabolism Electrophoresis, Polyacrylamide Gel Genes, myc - genetics Humans Hydrogen-Ion Concentration i-motif nucleic acid Nucleic Acid Conformation Oligonucleotides - chemistry Oligonucleotides - metabolism Promoter Regions, Genetic Spectrophotometry, Ultraviolet spectroscopy Temperature Thermodynamics transcription Transcription, Genetic
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