An Overview of the Immune System with Specific Reference to Membrane Encapsulation and Islet Transplantation

: The concept of immunoisolation by use of a bioartificial membrane is discussed, concentrating on the immunological mechanisms that are likely to be operative in the light of recent information on the workings of the immune system. Special attention is given to the use of encapsulation for the purp...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2001-11, Vol.944 (1), p.226-239
1. Verfasser:	GRAY, DEREK W.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bioartificial Organs immune system Immune System - physiology islet transplantation Islets of Langerhans Transplantation - immunology membrane encapsulation Membranes, Artificial overview Transplantation, Heterologous - immunology
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container_title	Annals of the New York Academy of Sciences
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creator	GRAY, DEREK W.R.
description	: The concept of immunoisolation by use of a bioartificial membrane is discussed, concentrating on the immunological mechanisms that are likely to be operative in the light of recent information on the workings of the immune system. Special attention is given to the use of encapsulation for the purpose of treating autoimmune diabetes by implantation of xenogeneic islet tissue. It is argued that the term immunoisolation is misleading because the immune system is always activated by the indirect pathway of antigen presentation and that the term immunomodulation would be more appropriate.
doi_str_mv	10.1111/j.1749-6632.2001.tb03835.x
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subjects	Animals Bioartificial Organs immune system Immune System - physiology islet transplantation Islets of Langerhans Transplantation - immunology membrane encapsulation Membranes, Artificial overview Transplantation, Heterologous - immunology
title	An Overview of the Immune System with Specific Reference to Membrane Encapsulation and Islet Transplantation
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