IL-17 stimulates intraperitoneal neutrophil infiltration through the release of GRO alpha chemokine from mesothelial cells

IL-17 is a newly discovered cytokine implicated in the regulation of hemopoiesis and inflammation. Because IL-17 production is restricted to activated T lymphocytes, the effects exerted by IL-17 may help one to understand the contribution of T cells to the inflammatory response. We investigated the...

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Veröffentlicht in:	The Journal of immunology (1950) 2000-11, Vol.165 (10), p.5814-5821
Hauptverfasser:	Witowski, J, Pawlaczyk, K, Breborowicz, A, Scheuren, A, Kuzlan-Pawlaczyk, M, Wisniewska, J, Polubinska, A, Friess, H, Gahl, G M, Frei, U, Jörres, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Chemokine CXCL1 Chemokines, CXC - metabolism Chemotactic Factors - biosynthesis Chemotactic Factors - genetics Chemotactic Factors - immunology Chemotactic Factors - metabolism Cycloheximide - pharmacology Dactinomycin - pharmacology Epithelium - immunology Epithelium - metabolism GRO^a protein Growth Substances - biosynthesis Growth Substances - genetics Growth Substances - immunology Growth Substances - metabolism Humans Immune Sera - administration & dosage Injections, Intraperitoneal Intercellular Signaling Peptides and Proteins Interleukin-17 - administration & dosage Interleukin-17 - antagonists & inhibitors Interleukin-17 - immunology Interleukin-17 - physiology Male Mice Mice, Inbred BALB C Neutrophil Infiltration - immunology Peritoneum - cytology Peritoneum - immunology Peritoneum - metabolism Protein Biosynthesis - drug effects Protein Biosynthesis - immunology Receptors, Interleukin - biosynthesis Receptors, Interleukin-17 Recombinant Proteins - biosynthesis RNA, Messenger - metabolism Transcription, Genetic - drug effects Transcription, Genetic - immunology Tumor Necrosis Factor-alpha - physiology
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