Role of Asp297 of the AT2 receptor in high-affinity binding to different peptide ligands

To determine how ligand-receptor interaction is affected by the charges of the amino acids at position 2 of the ligands and position 297 of the AT2 receptor, we generated the Asp297Lys mutant of AT2 and a ligand SarAsp 2Ile. Asp297Lys mutant lost affinity to Ang II and SarIle however retained partia...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2001-12, Vol.22 (12), p.2145-2149
Hauptverfasser:	Knowle, Dieter, Kurfis, Jayson, Gavini, Narasaiah, Pulakat, Lakshmidevi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Angiotensin II Aspartic Acid - metabolism AT2 receptor Ligands Molecular Sequence Data Phospholipase C Protein Binding Receptors, Angiotensin - chemistry Receptors, Angiotensin - metabolism Third extracellular loop Transmembrane domain Xenopus oocytes
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