Anti-HLA-DR/anti-DOTA diabody construction in a modular gene design platform: Bispecific antibodies for pretargeted radioimmunotherapy

Recombinant immunoglobulin libraries of single chain molecules (sc) from the variable domains of antibody light and heavy chains (Fv), have great promise for new approaches to radioimmunotherapy (RIT). However, creating and evaluating scFv from diverse sources is time consuming and differences in mo...

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Veröffentlicht in:Cancer biotherapy & radiopharmaceuticals 2001-12, Vol.16 (6), p.525-535
Hauptverfasser: DENARDO, David G, XIONG, Cheng-Yi, SHI, Xu-Bao, DENARDO, Gerald L, DENARDO, Sally J
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Sprache:eng
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