Left prefrontal activation predicts therapeutic effects of repetitive transcranial magnetic stimulation (rTMS) in major depression
There is evidence that repetitive transcranial magnetic stimulation (rTMS) applied to the prefrontal cortex has antidepressive properties. In the present study we evaluated the clinical status and the hemodynamic responses during mental work in the prefrontal cortex before therapeutic rTMS. Twelve p...
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| Veröffentlicht in: | Psychiatry research 2000-10, Vol.99 (3), p.161-172 |
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| creator | Eschweiler, Gerhard Wilhelm Wegerer, Christine Schlotter, Wilfried Spandl, Christoph Stevens, Andreas Bartels, Mathias Buchkremer, Gerhard |
| description | There is evidence that repetitive transcranial magnetic stimulation (rTMS) applied to the prefrontal cortex has antidepressive properties. In the present study we evaluated the clinical status and the hemodynamic responses during mental work in the prefrontal cortex before therapeutic rTMS. Twelve patients diagnosed with major depression (DSM-IV) were randomized in a sham-controlled cross-over treatment protocol of 4 weeks’ duration consisting of two periods of 5 days with rTMS separated by 9 days of no stimulation. rTMS (10 Hz) was applied to the left dorsolateral prefrontal cortex. Hemodynamic changes in the prefrontal cortex during mental work were evaluated by multi-site near-infrared spectroscopy (NIRS). Scores on the Hamilton Depression Rating Scale (HAMD) decreased significantly by −5.4 points after 5 days of active stimulation, whereas it did not change (+1.6 points) after sham stimulation. Absence of a task-related increase of total hemoglobin concentrations at the stimulation site (
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| doi_str_mv | 10.1016/S0925-4927(00)00062-7 |
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P<0.005), but not at other locations, before the first active rTMS significantly predicted the clinical response to active rTMS. Clinical benefits of rTMS are predicted by low local hemodynamic responses and support the idea of activation-dependent targeting of rTMS location.</description><identifier>ISSN: 0925-4927</identifier><identifier>ISSN: 0165-1781</identifier><identifier>EISSN: 1872-7506</identifier><identifier>DOI: 10.1016/S0925-4927(00)00062-7</identifier><identifier>PMID: 11068197</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Biological and medical sciences ; Brain Mapping ; Cerebrovascular Circulation ; Cross-Over Studies ; Depressive Disorder, Major - physiopathology ; Depressive Disorder, Major - psychology ; Depressive Disorder, Major - therapy ; Dominance, Cerebral ; Electric Stimulation Therapy - methods ; Electromagnetic Phenomena ; Female ; Humans ; Major depression ; Male ; Medical sciences ; Middle Aged ; Mirror drawing task ; Miscellaneous ; Near infrared spectroscopy ; Prefrontal Cortex - blood supply ; Prefrontal Cortex - metabolism ; Prognosis ; Psychology. Psychoanalysis. Psychiatry ; Psychomotor Performance ; Psychopathology. Psychiatry ; Repetitive transcranial magnetic stimulation ; Response prediction ; Total hemoglobin concentration ; Treatment Outcome ; Treatments</subject><ispartof>Psychiatry research, 2000-10, Vol.99 (3), p.161-172</ispartof><rights>2000 Elsevier Science Ireland Ltd</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-b58177b703c3483a67326c5b5e60dfdbefb26e0c195e2c1e5935269d830238ee3</citedby><cites>FETCH-LOGICAL-c456t-b58177b703c3483a67326c5b5e60dfdbefb26e0c195e2c1e5935269d830238ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0925492700000627$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1008597$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11068197$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eschweiler, Gerhard Wilhelm</creatorcontrib><creatorcontrib>Wegerer, Christine</creatorcontrib><creatorcontrib>Schlotter, Wilfried</creatorcontrib><creatorcontrib>Spandl, Christoph</creatorcontrib><creatorcontrib>Stevens, Andreas</creatorcontrib><creatorcontrib>Bartels, Mathias</creatorcontrib><creatorcontrib>Buchkremer, Gerhard</creatorcontrib><title>Left prefrontal activation predicts therapeutic effects of repetitive transcranial magnetic stimulation (rTMS) in major depression</title><title>Psychiatry research</title><addtitle>Psychiatry Res</addtitle><description>There is evidence that repetitive transcranial magnetic stimulation (rTMS) applied to the prefrontal cortex has antidepressive properties. In the present study we evaluated the clinical status and the hemodynamic responses during mental work in the prefrontal cortex before therapeutic rTMS. Twelve patients diagnosed with major depression (DSM-IV) were randomized in a sham-controlled cross-over treatment protocol of 4 weeks’ duration consisting of two periods of 5 days with rTMS separated by 9 days of no stimulation. rTMS (10 Hz) was applied to the left dorsolateral prefrontal cortex. Hemodynamic changes in the prefrontal cortex during mental work were evaluated by multi-site near-infrared spectroscopy (NIRS). Scores on the Hamilton Depression Rating Scale (HAMD) decreased significantly by −5.4 points after 5 days of active stimulation, whereas it did not change (+1.6 points) after sham stimulation. Absence of a task-related increase of total hemoglobin concentrations at the stimulation site (
P<0.005), but not at other locations, before the first active rTMS significantly predicted the clinical response to active rTMS. Clinical benefits of rTMS are predicted by low local hemodynamic responses and support the idea of activation-dependent targeting of rTMS location.</description><subject>Biological and medical sciences</subject><subject>Brain Mapping</subject><subject>Cerebrovascular Circulation</subject><subject>Cross-Over Studies</subject><subject>Depressive Disorder, Major - physiopathology</subject><subject>Depressive Disorder, Major - psychology</subject><subject>Depressive Disorder, Major - therapy</subject><subject>Dominance, Cerebral</subject><subject>Electric Stimulation Therapy - methods</subject><subject>Electromagnetic Phenomena</subject><subject>Female</subject><subject>Humans</subject><subject>Major depression</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mirror drawing task</subject><subject>Miscellaneous</subject><subject>Near infrared spectroscopy</subject><subject>Prefrontal Cortex - blood supply</subject><subject>Prefrontal Cortex - metabolism</subject><subject>Prognosis</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychomotor Performance</subject><subject>Psychopathology. Psychiatry</subject><subject>Repetitive transcranial magnetic stimulation</subject><subject>Response prediction</subject><subject>Total hemoglobin concentration</subject><subject>Treatment Outcome</subject><subject>Treatments</subject><issn>0925-4927</issn><issn>0165-1781</issn><issn>1872-7506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1vFSEUhklTY6_Vn9BmFo1pF2MPMMDMqjGNX8k1XbSuCcMclGa-CkwTt_5ymXtv1J0bIOc8vMADIWcU3lGg8voeGibKqmHqEuAKACQr1RHZ0FrlhQB5TDZ_kBPyKsZHAMZryV-SE0pB1rRRG_Jriy4Vc0AXpjGZvjA2-WeT_DSu1c7bFIv0A4OZcUneFugcrrXJFQFnTD7jWKRgxmjz4HPEYL6PuLIx-WHp92GX4eHr_VXhx9x-nELRYY6PMbdekxfO9BHfHOZT8u3jh4fbz-X27tOX2_fb0lZCprIVNVWqVcAtr2pupOJMWtEKlNC5rkXXMolgaSOQWYqi4YLJpqv5-mxEfkre7nPnMD0tGJMefLTY92bEaYlasSobqqsMij1owxRjVqPn4AcTfmoKepWvd_L1alYD6J18rfK-88MBSztg93fXwXYGLg6Aidb0LvuyPv6TDrXYYTd7DLONZ49BR-txtPk3Qnavu8n_5ya_AY15o0w</recordid><startdate>20001030</startdate><enddate>20001030</enddate><creator>Eschweiler, Gerhard Wilhelm</creator><creator>Wegerer, Christine</creator><creator>Schlotter, Wilfried</creator><creator>Spandl, Christoph</creator><creator>Stevens, Andreas</creator><creator>Bartels, Mathias</creator><creator>Buchkremer, Gerhard</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20001030</creationdate><title>Left prefrontal activation predicts therapeutic effects of repetitive transcranial magnetic stimulation (rTMS) in major depression</title><author>Eschweiler, Gerhard Wilhelm ; Wegerer, Christine ; Schlotter, Wilfried ; Spandl, Christoph ; Stevens, Andreas ; Bartels, Mathias ; Buchkremer, Gerhard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-b58177b703c3483a67326c5b5e60dfdbefb26e0c195e2c1e5935269d830238ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Biological and medical sciences</topic><topic>Brain Mapping</topic><topic>Cerebrovascular Circulation</topic><topic>Cross-Over Studies</topic><topic>Depressive Disorder, Major - physiopathology</topic><topic>Depressive Disorder, Major - psychology</topic><topic>Depressive Disorder, Major - therapy</topic><topic>Dominance, Cerebral</topic><topic>Electric Stimulation Therapy - methods</topic><topic>Electromagnetic Phenomena</topic><topic>Female</topic><topic>Humans</topic><topic>Major depression</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mirror drawing task</topic><topic>Miscellaneous</topic><topic>Near infrared spectroscopy</topic><topic>Prefrontal Cortex - blood supply</topic><topic>Prefrontal Cortex - metabolism</topic><topic>Prognosis</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychomotor Performance</topic><topic>Psychopathology. Psychiatry</topic><topic>Repetitive transcranial magnetic stimulation</topic><topic>Response prediction</topic><topic>Total hemoglobin concentration</topic><topic>Treatment Outcome</topic><topic>Treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eschweiler, Gerhard Wilhelm</creatorcontrib><creatorcontrib>Wegerer, Christine</creatorcontrib><creatorcontrib>Schlotter, Wilfried</creatorcontrib><creatorcontrib>Spandl, Christoph</creatorcontrib><creatorcontrib>Stevens, Andreas</creatorcontrib><creatorcontrib>Bartels, Mathias</creatorcontrib><creatorcontrib>Buchkremer, Gerhard</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Psychiatry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eschweiler, Gerhard Wilhelm</au><au>Wegerer, Christine</au><au>Schlotter, Wilfried</au><au>Spandl, Christoph</au><au>Stevens, Andreas</au><au>Bartels, Mathias</au><au>Buchkremer, Gerhard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Left prefrontal activation predicts therapeutic effects of repetitive transcranial magnetic stimulation (rTMS) in major depression</atitle><jtitle>Psychiatry research</jtitle><addtitle>Psychiatry Res</addtitle><date>2000-10-30</date><risdate>2000</risdate><volume>99</volume><issue>3</issue><spage>161</spage><epage>172</epage><pages>161-172</pages><issn>0925-4927</issn><issn>0165-1781</issn><eissn>1872-7506</eissn><abstract>There is evidence that repetitive transcranial magnetic stimulation (rTMS) applied to the prefrontal cortex has antidepressive properties. In the present study we evaluated the clinical status and the hemodynamic responses during mental work in the prefrontal cortex before therapeutic rTMS. Twelve patients diagnosed with major depression (DSM-IV) were randomized in a sham-controlled cross-over treatment protocol of 4 weeks’ duration consisting of two periods of 5 days with rTMS separated by 9 days of no stimulation. rTMS (10 Hz) was applied to the left dorsolateral prefrontal cortex. Hemodynamic changes in the prefrontal cortex during mental work were evaluated by multi-site near-infrared spectroscopy (NIRS). Scores on the Hamilton Depression Rating Scale (HAMD) decreased significantly by −5.4 points after 5 days of active stimulation, whereas it did not change (+1.6 points) after sham stimulation. Absence of a task-related increase of total hemoglobin concentrations at the stimulation site (
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| subjects | Biological and medical sciences Brain Mapping Cerebrovascular Circulation Cross-Over Studies Depressive Disorder, Major - physiopathology Depressive Disorder, Major - psychology Depressive Disorder, Major - therapy Dominance, Cerebral Electric Stimulation Therapy - methods Electromagnetic Phenomena Female Humans Major depression Male Medical sciences Middle Aged Mirror drawing task Miscellaneous Near infrared spectroscopy Prefrontal Cortex - blood supply Prefrontal Cortex - metabolism Prognosis Psychology. Psychoanalysis. Psychiatry Psychomotor Performance Psychopathology. Psychiatry Repetitive transcranial magnetic stimulation Response prediction Total hemoglobin concentration Treatment Outcome Treatments |
| title | Left prefrontal activation predicts therapeutic effects of repetitive transcranial magnetic stimulation (rTMS) in major depression |
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