CD99 (E2) up-regulates alpha4beta1-dependent T cell adhesion to inflamed vascular endothelium under flow conditions

CD99/E2 is an integral transmembrane protein which forms, together with Xga, a distinct family whose genes are located in the pseudoautosomal region. The number of T cells that firmly bound to vascular endothelial cells under physiological shear stress increased 2-14-fold upon CD99 stimulation, and...

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Veröffentlicht in:	European journal of immunology 2000-10, Vol.30 (10), p.3061-3065
Hauptverfasser:	Bernard, G, Raimondi, V, Alberti, I, Pourtein, M, Widjenes, J, Ticchioni, M, Bernard, A
Format:	Artikel
Sprache:	eng
Schlagworte:	12E7 Antigen Actins - metabolism Antigens, CD - physiology Biological Transport Biopolymers Cell Adhesion - drug effects Cell Adhesion Molecules - physiology Cell Movement - drug effects Cell Size Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Humans Integrin alpha4beta1 Integrins - physiology Intercellular Adhesion Molecule-1 - genetics Intercellular Adhesion Molecule-1 - physiology Jurkat Cells Leukemia-Lymphoma, Adult T-Cell - pathology Neoplasm Proteins - physiology Phytohemagglutinins - pharmacology Receptors, Lymphocyte Homing - physiology Recombinant Fusion Proteins - physiology Rheology Stress, Mechanical T-Lymphocytes - cytology Tumor Cells, Cultured Tumor Necrosis Factor-alpha - pharmacology Vascular Cell Adhesion Molecule-1 - genetics Vascular Cell Adhesion Molecule-1 - physiology
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