CD99 (E2) up-regulates alpha4beta1-dependent T cell adhesion to inflamed vascular endothelium under flow conditions
CD99/E2 is an integral transmembrane protein which forms, together with Xga, a distinct family whose genes are located in the pseudoautosomal region. The number of T cells that firmly bound to vascular endothelial cells under physiological shear stress increased 2-14-fold upon CD99 stimulation, and...
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| Veröffentlicht in: | European journal of immunology 2000-10, Vol.30 (10), p.3061-3065 |
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| container_title | European journal of immunology |
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| creator | Bernard, G Raimondi, V Alberti, I Pourtein, M Widjenes, J Ticchioni, M Bernard, A |
| description | CD99/E2 is an integral transmembrane protein which forms, together with Xga, a distinct family whose genes are located in the pseudoautosomal region. The number of T cells that firmly bound to vascular endothelial cells under physiological shear stress increased 2-14-fold upon CD99 stimulation, and bound cells became much more resistant to detachment forces and spread. T cell arrest occurred within 1 min and was dependent on the alpha4beta1-VCAM-1 pathway. In contrast, the alphaLbeta2-ICAM-1 pathway remained unactivated. This was observed with T cell lines and with activated peripheral blood lymphocytes, and was limited within the resting peripheral CD4+ T cells to the memory subset, while virgin cells were unaffected. This discloses a stepwise regulation of the T cell extravasation cascade. |
| format | Article |
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The number of T cells that firmly bound to vascular endothelial cells under physiological shear stress increased 2-14-fold upon CD99 stimulation, and bound cells became much more resistant to detachment forces and spread. T cell arrest occurred within 1 min and was dependent on the alpha4beta1-VCAM-1 pathway. In contrast, the alphaLbeta2-ICAM-1 pathway remained unactivated. This was observed with T cell lines and with activated peripheral blood lymphocytes, and was limited within the resting peripheral CD4+ T cells to the memory subset, while virgin cells were unaffected. 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This discloses a stepwise regulation of the T cell extravasation cascade.</description><subject>12E7 Antigen</subject><subject>Actins - metabolism</subject><subject>Antigens, CD - physiology</subject><subject>Biological Transport</subject><subject>Biopolymers</subject><subject>Cell Adhesion - drug effects</subject><subject>Cell Adhesion Molecules - physiology</subject><subject>Cell Movement - drug effects</subject><subject>Cell Size</subject><subject>Endothelium, Vascular - cytology</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Humans</subject><subject>Integrin alpha4beta1</subject><subject>Integrins - physiology</subject><subject>Intercellular Adhesion Molecule-1 - genetics</subject><subject>Intercellular Adhesion Molecule-1 - physiology</subject><subject>Jurkat Cells</subject><subject>Leukemia-Lymphoma, Adult T-Cell - pathology</subject><subject>Neoplasm Proteins - physiology</subject><subject>Phytohemagglutinins - pharmacology</subject><subject>Receptors, Lymphocyte Homing - physiology</subject><subject>Recombinant Fusion Proteins - physiology</subject><subject>Rheology</subject><subject>Stress, Mechanical</subject><subject>T-Lymphocytes - cytology</subject><subject>Tumor Cells, Cultured</subject><subject>Tumor Necrosis Factor-alpha - pharmacology</subject><subject>Vascular Cell Adhesion Molecule-1 - genetics</subject><subject>Vascular Cell Adhesion Molecule-1 - physiology</subject><issn>0014-2980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kD1PwzAQhj2AaCn8BeQJwRDJTtyQG1EpH1Illu7RxT7TICcOsQ3i32NEWe6W53l1956wpRBSFSU0YsHOQ3gXQkC9hjO2kFLUIEAuWdg8APCbbXnL01TM9JYcRgoc3XRA1VFEWRiaaDQ0Rr7nmpzjaA4Uej_y6Hk_WocDGf6JQWd55pn18UCuTwNP2Zu5df6Laz-aPmYrXLBTiy7Q5XGv2P5xu988F7vXp5fN_a6Y1koWVqM21AgN0ICRWjVNLaTMs-y0pHUD1ijskGoy1lRVbRWAwIwJANuZasWu_2Kn2X8kCrEd-vB7P47kU2jvSpULEpDBqyOYuvxJO839gPN3-99S9QMOFmN0</recordid><startdate>200010</startdate><enddate>200010</enddate><creator>Bernard, G</creator><creator>Raimondi, V</creator><creator>Alberti, I</creator><creator>Pourtein, M</creator><creator>Widjenes, J</creator><creator>Ticchioni, M</creator><creator>Bernard, A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200010</creationdate><title>CD99 (E2) up-regulates alpha4beta1-dependent T cell adhesion to inflamed vascular endothelium under flow conditions</title><author>Bernard, G ; 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The number of T cells that firmly bound to vascular endothelial cells under physiological shear stress increased 2-14-fold upon CD99 stimulation, and bound cells became much more resistant to detachment forces and spread. T cell arrest occurred within 1 min and was dependent on the alpha4beta1-VCAM-1 pathway. In contrast, the alphaLbeta2-ICAM-1 pathway remained unactivated. This was observed with T cell lines and with activated peripheral blood lymphocytes, and was limited within the resting peripheral CD4+ T cells to the memory subset, while virgin cells were unaffected. This discloses a stepwise regulation of the T cell extravasation cascade.</abstract><cop>Germany</cop><pmid>11069091</pmid><tpages>5</tpages></addata></record> |
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| ispartof | European journal of immunology, 2000-10, Vol.30 (10), p.3061-3065 |
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| language | eng |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE; Wiley Free Content; EZB-FREE-00999 freely available EZB journals |
| subjects | 12E7 Antigen Actins - metabolism Antigens, CD - physiology Biological Transport Biopolymers Cell Adhesion - drug effects Cell Adhesion Molecules - physiology Cell Movement - drug effects Cell Size Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Humans Integrin alpha4beta1 Integrins - physiology Intercellular Adhesion Molecule-1 - genetics Intercellular Adhesion Molecule-1 - physiology Jurkat Cells Leukemia-Lymphoma, Adult T-Cell - pathology Neoplasm Proteins - physiology Phytohemagglutinins - pharmacology Receptors, Lymphocyte Homing - physiology Recombinant Fusion Proteins - physiology Rheology Stress, Mechanical T-Lymphocytes - cytology Tumor Cells, Cultured Tumor Necrosis Factor-alpha - pharmacology Vascular Cell Adhesion Molecule-1 - genetics Vascular Cell Adhesion Molecule-1 - physiology |
| title | CD99 (E2) up-regulates alpha4beta1-dependent T cell adhesion to inflamed vascular endothelium under flow conditions |
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