Experimental infection of Australian brushtail possums, Trichosurus vulpecula (Phalangeridae: Marsupialia), with Ross River and Barmah Forest viruses by use of a natural mosquito vector system
Brushtail possums, Trichosurus vulpecula Kerr, were experimentally infected with Ross River (RR) or Barmah Forest (BF) virus by Aedes vigilax (Skuse) mosquitoes. Eight of 10 animals exposed to RR virus developed neutralizing antibody, and 3 possums developed high viremia for < 48 hr after infecti...
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| Veröffentlicht in: | The American journal of tropical medicine and hygiene 2001-12, Vol.65 (6), p.777-782 |
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| container_title | The American journal of tropical medicine and hygiene |
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| creator | Boyd, AM Hall, RA Gemmell, RT Kay, BH |
| description | Brushtail possums, Trichosurus vulpecula Kerr, were experimentally infected with Ross River (RR) or Barmah Forest (BF) virus by Aedes vigilax (Skuse) mosquitoes. Eight of 10 animals exposed to RR virus developed neutralizing antibody, and 3 possums developed high viremia for < 48 hr after infection, sufficient to infect recipient mosquitoes. Two of 10 animals exposed to BF virus developed neutralizing antibody. Both infected possums maintained detectable neutralizing antibody to BF for at least 45 days after infection (log neutralization index > 2.0 at 45 days). Eight possums did not develop neutralizing antibody to BF despite exposure to infected mosquitoes. These results suggest that T. vulpecula may potentially act as a reservoir species for RR in urban areas. However, T. vulpecula infected with BF do not develop viremia sufficient to infect mosquitoes and are unlikely to be important hosts for BF. |
| doi_str_mv | 10.4269/ajtmh.2001.65.777 |
| format | Article |
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However, T. vulpecula infected with BF do not develop viremia sufficient to infect mosquitoes and are unlikely to be important hosts for BF.</description><subject>Aedes - virology</subject><subject>Alphavirus - immunology</subject><subject>Alphavirus Infections - epidemiology</subject><subject>Alphavirus Infections - transmission</subject><subject>Animals</subject><subject>Antibodies, Viral - blood</subject><subject>Biological and medical sciences</subject><subject>Disease Reservoirs - veterinary</subject><subject>Experimental viral diseases and models</subject><subject>Female</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Insect Vectors - virology</subject><subject>Male</subject><subject>Marsupialia - virology</subject><subject>Medical sciences</subject><subject>Queensland - epidemiology</subject><subject>Ross River virus</subject><subject>Ross River virus - immunology</subject><subject>Trichosurus vulpecula</subject><subject>Tropical medicine</subject><subject>Viral diseases</subject><issn>0002-9637</issn><issn>1476-1645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAUhS0EokPhAdiguwGB1Ax2nMRJd6VqAakIVJW1dZM4jSvnp_6ZdN6uj4anHWmWrO7C3z33-BxC3jO6ztKi-op3fujXKaVsXeRrIcQLsmKZKBJWZPlLsqKUpklVcHFE3jh3F7kyZew1OWJMVKwS2Yo8XjzMyupBjR4N6LFTjdfTCFMHZ8F5i0bjCLUNrveoDcyTc2FwJ3BjddNPLsQX2AQzqyYYhM9_ejQ43kbJFtUp_ELrwqx3Kl9OYNG-h-uoANd6oyzg2MI3tAP2cDlZ5TxsdNRTDuotxLlzgTCiD9EHDJO7D9pPsIkeJwtu67wa3pJXHRqn3u3nMfl7eXFz_iO5-v395_nZVdLwsvRJlpecZ7wp26ZDVRe8pXVWddgKkbdlTCYXBc2Z4JQrzqqs5CxPqWA8rVVes5ofk0_PurOd7kP0KgftGmXib9UUnBQpryrB2H9BVvKU07SMIHsGGxsjsaqTcywC7VYyKnf9yqd-5a5fWeQy9ht3PuzFQz2o9rCxLzQCH_cAugZNZ3FstDtwMQMuKnHgen3bL9oq6QY0JsoyuSxLPFc8HfwHYu-_6Q</recordid><startdate>20011201</startdate><enddate>20011201</enddate><creator>Boyd, AM</creator><creator>Hall, RA</creator><creator>Gemmell, RT</creator><creator>Kay, BH</creator><general>ASTMH</general><general>Allen Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20011201</creationdate><title>Experimental infection of Australian brushtail possums, Trichosurus vulpecula (Phalangeridae: Marsupialia), with Ross River and Barmah Forest viruses by use of a natural mosquito vector system</title><author>Boyd, AM ; Hall, RA ; Gemmell, RT ; Kay, BH</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-4583343c8dcfaeb63d0b49fad775d80015760517303e31948315207132be5b1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Aedes - virology</topic><topic>Alphavirus - immunology</topic><topic>Alphavirus Infections - epidemiology</topic><topic>Alphavirus Infections - transmission</topic><topic>Animals</topic><topic>Antibodies, Viral - blood</topic><topic>Biological and medical sciences</topic><topic>Disease Reservoirs - veterinary</topic><topic>Experimental viral diseases and models</topic><topic>Female</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Insect Vectors - virology</topic><topic>Male</topic><topic>Marsupialia - virology</topic><topic>Medical sciences</topic><topic>Queensland - epidemiology</topic><topic>Ross River virus</topic><topic>Ross River virus - immunology</topic><topic>Trichosurus vulpecula</topic><topic>Tropical medicine</topic><topic>Viral diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boyd, AM</creatorcontrib><creatorcontrib>Hall, RA</creatorcontrib><creatorcontrib>Gemmell, RT</creatorcontrib><creatorcontrib>Kay, BH</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of tropical medicine and hygiene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boyd, AM</au><au>Hall, RA</au><au>Gemmell, RT</au><au>Kay, BH</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental infection of Australian brushtail possums, Trichosurus vulpecula (Phalangeridae: Marsupialia), with Ross River and Barmah Forest viruses by use of a natural mosquito vector system</atitle><jtitle>The American journal of tropical medicine and hygiene</jtitle><addtitle>Am J Trop Med Hyg</addtitle><date>2001-12-01</date><risdate>2001</risdate><volume>65</volume><issue>6</issue><spage>777</spage><epage>782</epage><pages>777-782</pages><issn>0002-9637</issn><eissn>1476-1645</eissn><coden>AJTHAB</coden><abstract>Brushtail possums, Trichosurus vulpecula Kerr, were experimentally infected with Ross River (RR) or Barmah Forest (BF) virus by Aedes vigilax (Skuse) mosquitoes. Eight of 10 animals exposed to RR virus developed neutralizing antibody, and 3 possums developed high viremia for < 48 hr after infection, sufficient to infect recipient mosquitoes. Two of 10 animals exposed to BF virus developed neutralizing antibody. Both infected possums maintained detectable neutralizing antibody to BF for at least 45 days after infection (log neutralization index > 2.0 at 45 days). Eight possums did not develop neutralizing antibody to BF despite exposure to infected mosquitoes. These results suggest that T. vulpecula may potentially act as a reservoir species for RR in urban areas. However, T. vulpecula infected with BF do not develop viremia sufficient to infect mosquitoes and are unlikely to be important hosts for BF.</abstract><cop>Lawrence, KS</cop><pub>ASTMH</pub><pmid>11791974</pmid><doi>10.4269/ajtmh.2001.65.777</doi><tpages>6</tpages></addata></record> |
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| ispartof | The American journal of tropical medicine and hygiene, 2001-12, Vol.65 (6), p.777-782 |
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| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Aedes - virology Alphavirus - immunology Alphavirus Infections - epidemiology Alphavirus Infections - transmission Animals Antibodies, Viral - blood Biological and medical sciences Disease Reservoirs - veterinary Experimental viral diseases and models Female Humans Infectious diseases Insect Vectors - virology Male Marsupialia - virology Medical sciences Queensland - epidemiology Ross River virus Ross River virus - immunology Trichosurus vulpecula Tropical medicine Viral diseases |
| title | Experimental infection of Australian brushtail possums, Trichosurus vulpecula (Phalangeridae: Marsupialia), with Ross River and Barmah Forest viruses by use of a natural mosquito vector system |
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