IS THE POPULATION SIZE OF A SPECIES RELEVANT TO ITS EVOLUTION?
This paper examines aspects of genetic draft, the stochastic force induced by substitutions at one locus on the dynamics of a closely linked locus. Of particular interest is the role of population size on genetic draft. Remarkably, the rate of substitution of weakly selected advantageous mutations d...
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| Veröffentlicht in: | Evolution 2001-11, Vol.55 (11), p.2161-2169 |
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| creator | Gillespie, John H |
| description | This paper examines aspects of genetic draft, the stochastic force induced by substitutions at one locus on the dynamics of a closely linked locus. Of particular interest is the role of population size on genetic draft. Remarkably, the rate of substitution of weakly selected advantageous mutations decreases with increasing population size, whereas that for deleterious mutations increases with population size. This dependency on population size is the opposite of that for genetic drift. Moreover, these rates are only weakly dependent on population size, again contrary to the strong dependency of drift-based dynamics. Four models of the strongly selected loci responsible for genetic draft are examined. Three of these exhibit a very weak dependency on population size, which implies that their induced effects will also be weakly dependent on population size. Together, these results suggest that population size and binomial sampling may not be relevant to a species' evolution. If this is the case, then a number of evolutionary conundrums are resolved. Corresponding Editor: A. Caballero |
| doi_str_mv | 10.1554/0014-3820(2001)055[2161:ITPSOA]2.0.CO;2 |
| format | Article |
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Of particular interest is the role of population size on genetic draft. Remarkably, the rate of substitution of weakly selected advantageous mutations decreases with increasing population size, whereas that for deleterious mutations increases with population size. This dependency on population size is the opposite of that for genetic drift. Moreover, these rates are only weakly dependent on population size, again contrary to the strong dependency of drift-based dynamics. Four models of the strongly selected loci responsible for genetic draft are examined. Three of these exhibit a very weak dependency on population size, which implies that their induced effects will also be weakly dependent on population size. Together, these results suggest that population size and binomial sampling may not be relevant to a species' evolution. If this is the case, then a number of evolutionary conundrums are resolved. Corresponding Editor: A. Caballero</description><subject>Alleles</subject><subject>Animals</subject><subject>Binomial sampling</subject><subject>Biological Evolution</subject><subject>Evolution</subject><subject>Evolutionary genetics</subject><subject>genetic draft</subject><subject>Genetic drift</subject><subject>Genetic loci</subject><subject>Genetic mutation</subject><subject>Genetics</subject><subject>Genetics, Population</subject><subject>Genotype</subject><subject>Hitchhiking</subject><subject>Mathematics</subject><subject>molecular evolution</subject><subject>Molecular genetics</subject><subject>Mutation</subject><subject>natural selection</subject><subject>Phenotype</subject><subject>Population</subject><subject>Population Density</subject><subject>Population genetics</subject><subject>Population size</subject><subject>REGULAR ARTICLES</subject><issn>0014-3820</issn><issn>1558-5646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqdkVFr2zAUhcXYaNOs_2AMsYfSPTi9kiVL2mDDGLU1mCrMTh82hpATGRKSuLWTh_37yTh0sJfBniS43z33nnsQuiEwI5yzGwDColhSuKbh-xE4_0FJQj7l1bw06U86g1lmPtNXaBJwGfGEJa_R5KXrHF30_QYAFCfqDJ0TIhQTQkzQl7zE1b3GczNfFGmVmwdc5t81Nrc4xeVcZ7ku8Tdd6Mf0ocKVwXlVYv1oisXAfn2L3jRu2_vL0ztFi1tdZfdRYe7yLC2imoM6RNwpxsJsp6DxDQdOwMnaJ5wySRlw55yKfaIYhWW8akTiZUyCQSprsWKKxVN0Neo-de3z0fcHu1v3S7_dur1vj70VNFaKyfifIJE0kYqLAH74C9y0x24fTFhKBbA4iAXoboSWXdv3nW_sU7feue6XJWCHYOxwYjuc2A7B2BCMHYKxYzCWWrCZsTQovT-NO9Y7v_qjc0oiAO9GYNMf2u6lHraFOBibIj2W63Xb7v1_7_EbQyShQg</recordid><startdate>20011101</startdate><enddate>20011101</enddate><creator>Gillespie, John H</creator><general>Society for the Study of Evolution</general><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20011101</creationdate><title>IS THE POPULATION SIZE OF A SPECIES RELEVANT TO ITS EVOLUTION?</title><author>Gillespie, John H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b509t-5a944951a90fef50510a8be652482405aaa93e69420c3df76e83121628b7d4943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Alleles</topic><topic>Animals</topic><topic>Binomial sampling</topic><topic>Biological Evolution</topic><topic>Evolution</topic><topic>Evolutionary genetics</topic><topic>genetic draft</topic><topic>Genetic drift</topic><topic>Genetic loci</topic><topic>Genetic mutation</topic><topic>Genetics</topic><topic>Genetics, Population</topic><topic>Genotype</topic><topic>Hitchhiking</topic><topic>Mathematics</topic><topic>molecular evolution</topic><topic>Molecular genetics</topic><topic>Mutation</topic><topic>natural selection</topic><topic>Phenotype</topic><topic>Population</topic><topic>Population Density</topic><topic>Population genetics</topic><topic>Population size</topic><topic>REGULAR ARTICLES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gillespie, John H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - 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Of particular interest is the role of population size on genetic draft. Remarkably, the rate of substitution of weakly selected advantageous mutations decreases with increasing population size, whereas that for deleterious mutations increases with population size. This dependency on population size is the opposite of that for genetic drift. Moreover, these rates are only weakly dependent on population size, again contrary to the strong dependency of drift-based dynamics. Four models of the strongly selected loci responsible for genetic draft are examined. Three of these exhibit a very weak dependency on population size, which implies that their induced effects will also be weakly dependent on population size. Together, these results suggest that population size and binomial sampling may not be relevant to a species' evolution. If this is the case, then a number of evolutionary conundrums are resolved. Corresponding Editor: A. 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| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Wiley Online Library Journals Frontfile Complete; BioOne; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Alleles Animals Binomial sampling Biological Evolution Evolution Evolutionary genetics genetic draft Genetic drift Genetic loci Genetic mutation Genetics Genetics, Population Genotype Hitchhiking Mathematics molecular evolution Molecular genetics Mutation natural selection Phenotype Population Population Density Population genetics Population size REGULAR ARTICLES |
| title | IS THE POPULATION SIZE OF A SPECIES RELEVANT TO ITS EVOLUTION? |
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