The induction of cyclooxygenase-2 by 17beta-estradiol in endothelial cells is mediated through protein kinase C

We investigated whether estrogen affected COX isoform expressed in human umbilical vein endothelial cells (HUVEC). HUVEC were grown to confluence and replaced with fresh medium containing 17beta-estradiol (0.001, 0.01, 0.1 and 1 nM) or 17beta-estradiol (1 nM) plus staurosporine (0.1, 1 and 10 ng/ml)...

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Veröffentlicht in:	Inflammation research 2000-09, Vol.49 (9), p.460-465
Hauptverfasser:	Akarasereenont, P, Techatraisak, K, Thaworn, A, Chotewuttakorn, S
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Ketoprostaglandin F1 alpha - biosynthesis Cells, Cultured Cyclooxygenase 1 Cyclooxygenase 2 Endothelium, Vascular - enzymology Enzyme Induction - drug effects Epoprostenol - biosynthesis Estradiol - pharmacology Humans Isoenzymes - biosynthesis Membrane Proteins Prostaglandin-Endoperoxide Synthases - biosynthesis Protein Kinase C - physiology
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