Induction of Antitumor Immunity by Vaccination of Dendritic Cells Transfected with MUC1 RNA

Dendritic cells (DC) are potent APCs. In this study, murine bone marrow-derived DC were transfected with RNA encoding the MUC1 Ag that is aberrantly overexpressed in human breast and other carcinomas. The MUC1 RNA-transfected DC exhibited cell surface expression of MUC1 and costimulatory molecules....

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Veröffentlicht in:	The Journal of immunology (1950) 2000-11, Vol.165 (10), p.5713-5719
Hauptverfasser:	Koido, Shigeo, Kashiwaba, Masahiro, Chen, Dongshu, Gendler, Sandra, Kufe, Donald, Gong, Jianlin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody Formation - genetics Antigens, Neoplasm - immunology Breast Neoplasms - genetics Breast Neoplasms - immunology Breast Neoplasms - pathology Breast Neoplasms - prevention & control cancer vaccines Cancer Vaccines - administration & dosage Cancer Vaccines - genetics Cancer Vaccines - immunology Cells, Cultured Cytotoxicity, Immunologic - genetics Dendritic Cells - immunology Dendritic Cells - metabolism Dendritic Cells - transplantation Female Gene Expression - immunology Humans Immune Tolerance - genetics Injections, Subcutaneous Mice Mice, Inbred C57BL Mice, Transgenic MUC-1 antigen Mucins - administration & dosage Mucins - biosynthesis Mucins - genetics Mucins - immunology RNA - administration & dosage RNA - genetics RNA - immunology T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Cytotoxic - metabolism Transfection - methods Tumor Cells, Cultured
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