Dissimilar Immunogenicities of Human Papillomavirus E7 and Adenovirus E1A Proteins Influence Primary Tumor Development

Although human papillomaviruses (HPV) and adenoviruses (Ad) both transform cells by expressing functionally related oncogenes (Ad-E1A/E1B; HPV-E7/E6), only HPV are oncogenic in humans. Prior studies have shown that HPV-transformed cells are resistant to NK cell lysis and E7- and E6-specific CTL are...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2000-11, Vol.277 (1), p.48-57
Hauptverfasser:	Routes, John M., Ryan, Sharon, Li, Han, Steinke, John, Cook, James L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenovirus Adenovirus E1A Proteins - immunology adenoviruses Adenoviruses, Human - genetics AE1A protein AE7 protein Animals Cytotoxicity, Immunologic E1A E7 protein Female Fibrosarcoma - immunology Fibrosarcoma - virology human papillomavirus Humans Killer Cells, Natural - immunology Mice Mice, Inbred C57BL Mice, Nude Mice, Transgenic NK cells Oncogene Proteins, Viral - immunology Oncogenes Papillomaviridae - genetics Papillomavirus E7 Proteins papillomaviruses Serotyping T-Lymphocytes - immunology T-Lymphocytes, Cytotoxic - immunology Tumor Cells, Cultured Xenograft Model Antitumor Assays
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