Selective Inhibition of Cyclooxygenase-2 by C-Phycocyanin, a Biliprotein from Spirulina platensis

We report data from two related assay systems (isolated enzyme assays and whole blood assays) that C-phycocyanin a biliprotein from Spirulina platensis is a selective inhibitor of cyclooxygenase-2 (COX-2) with a very low IC50 COX-2/IC50 COX-1 ratio (0.04). The extent of inhibition depends on the per...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemical and biophysical research communications 2000-11, Vol.277 (3), p.599-603
Hauptverfasser:	Reddy, C.Madhava, Bhat, Vadiraja B., Kiranmai, G., Reddy, M.Narsa, Reddanna, P., Madyastha, K.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals biliproteins C-phycocyanin Celecoxib Cyanobacteria - chemistry Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors - pharmacology cyclooxygenase-1 Dose-Response Relationship, Drug Humans inhibition Insect Proteins - metabolism Isoenzymes - antagonists & inhibitors Isoenzymes - metabolism Lactones - pharmacology Membrane Proteins Microsomes - metabolism nonsteroidal anti-inflammatory drugs phycocyanin Phycocyanin - pharmacology phycocyanobilin Prostaglandin-Endoperoxide Synthases - metabolism Pyrazoles reduced phycocyanin Sheep Spirulina platensis Sulfonamides - pharmacology Sulfones
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!